Diagnostic value of FDG-PET/CT in fever of unknown origin

Background Fever of unknown origin (FUO) is a challenging clinical problem in medicine that needs collaboration of various diagnostic techniques to establish the accurate diagnosis. We evaluated the diagnostic performance of 18F-FDG PET/CT in patients who presented themselves with FUO. Our study inc...

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Veröffentlicht in:Egyptian Journal of Radiology and Nuclear Medicine 2022-03, Vol.53 (1), p.1-11, Article 55
Hauptverfasser: Elshalakani, Maha Omar Mohamed, Chalabi, Nivine, Hanafy, Hanan Mohamed, Othman, Amal Ibrahim Ahmed
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container_issue 1
container_start_page 1
container_title Egyptian Journal of Radiology and Nuclear Medicine
container_volume 53
creator Elshalakani, Maha Omar Mohamed
Chalabi, Nivine
Hanafy, Hanan Mohamed
Othman, Amal Ibrahim Ahmed
description Background Fever of unknown origin (FUO) is a challenging clinical problem in medicine that needs collaboration of various diagnostic techniques to establish the accurate diagnosis. We evaluated the diagnostic performance of 18F-FDG PET/CT in patients who presented themselves with FUO. Our study included 40 patients with FUO who underwent PET/CT examination and their results were compared to the results of laboratory, histopathological, microbiological investigations and/or response to therapy. Results The final diagnosis included malignancy in 20 patients (50%), infectious causes in 7 patients (17.5%) and non-infectious inflammatory causes in 6 patients (15%). Fever resolved without diagnosis in 4 patients (10%), while no definite diagnosis was reached in 3 patients (7%). PET/CT successfully contributed to diagnosis of 35 out of 40 patients with diagnostic accuracy of 87.5%. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT in our study were 93.5%, 66.7%, 90.6% and 75%, respectively. Conclusion PET/CT is a useful tool to investigate and diagnose the cause of FUO. It provides information that can guide the treatment strategy of the patients.
doi_str_mv 10.1186/s43055-022-00725-z
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We evaluated the diagnostic performance of 18F-FDG PET/CT in patients who presented themselves with FUO. Our study included 40 patients with FUO who underwent PET/CT examination and their results were compared to the results of laboratory, histopathological, microbiological investigations and/or response to therapy. Results The final diagnosis included malignancy in 20 patients (50%), infectious causes in 7 patients (17.5%) and non-infectious inflammatory causes in 6 patients (15%). Fever resolved without diagnosis in 4 patients (10%), while no definite diagnosis was reached in 3 patients (7%). PET/CT successfully contributed to diagnosis of 35 out of 40 patients with diagnostic accuracy of 87.5%. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT in our study were 93.5%, 66.7%, 90.6% and 75%, respectively. Conclusion PET/CT is a useful tool to investigate and diagnose the cause of FUO. 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We evaluated the diagnostic performance of 18F-FDG PET/CT in patients who presented themselves with FUO. Our study included 40 patients with FUO who underwent PET/CT examination and their results were compared to the results of laboratory, histopathological, microbiological investigations and/or response to therapy. Results The final diagnosis included malignancy in 20 patients (50%), infectious causes in 7 patients (17.5%) and non-infectious inflammatory causes in 6 patients (15%). Fever resolved without diagnosis in 4 patients (10%), while no definite diagnosis was reached in 3 patients (7%). PET/CT successfully contributed to diagnosis of 35 out of 40 patients with diagnostic accuracy of 87.5%. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT in our study were 93.5%, 66.7%, 90.6% and 75%, respectively. Conclusion PET/CT is a useful tool to investigate and diagnose the cause of FUO. It provides information that can guide the treatment strategy of the patients.</description><subject>FDG PET/CT</subject><subject>Fever of unknown origin</subject><subject>Imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Medicine, Experimental</subject><subject>Nuclear Medicine</subject><subject>PET imaging</subject><subject>Radiology</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>DOA</sourceid><recordid>eNp9kctKAzEYhQdRsGhfwNWA66mZ3GayEaTVWhB0Udchk8uY2iYlaSv26c10RCyIySLh5JzvD5wsuyrBqCxrehMxAoQUAMICgAqSYn-SDSBgoMAVhae_7ufZMMYFSAsDUFI8yNjEitb5uLEy34nlVufe5A-TafFyP78Zz3PrcqN3OnTy1r07_-FyH2xr3WV2ZsQy6uH3eZG9PtzPx4_F0_N0Nr57KiSBaFNIozSjqJGYAUQQakxjoGZVzZCkSglCCVTKYEmQREYwWklsOkkgDGtC0EU267nKiwVfB7sS4ZN7YflB8KHlIqTvLzVXEDKCiSCVFJhgwYCpa8lwZRqSUB3rtmett81KK6ndJojlEfT4xdk33vodr-uaIgIS4LoHtCLNs874ZJMrGyW_o91sRBlLrtEfrrSVXlnpnTY26UcB2Adk8DEGbX6-VALedcz7jnnqmB865vsUQn0oJrNrdeALvw0udfFf6gs-Uqgm</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Elshalakani, Maha Omar Mohamed</creator><creator>Chalabi, Nivine</creator><creator>Hanafy, Hanan Mohamed</creator><creator>Othman, Amal Ibrahim Ahmed</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0835-8181</orcidid></search><sort><creationdate>20220301</creationdate><title>Diagnostic value of FDG-PET/CT in fever of unknown origin</title><author>Elshalakani, Maha Omar Mohamed ; Chalabi, Nivine ; Hanafy, Hanan Mohamed ; Othman, Amal Ibrahim Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-cfde963bc4903533bfbf2e97893c6dda5652ddf4c53c3fa967c4f52dda3428553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>FDG PET/CT</topic><topic>Fever of unknown origin</topic><topic>Imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Medicine, Experimental</topic><topic>Nuclear Medicine</topic><topic>PET imaging</topic><topic>Radiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elshalakani, Maha Omar Mohamed</creatorcontrib><creatorcontrib>Chalabi, Nivine</creatorcontrib><creatorcontrib>Hanafy, Hanan Mohamed</creatorcontrib><creatorcontrib>Othman, Amal Ibrahim Ahmed</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elshalakani, Maha Omar Mohamed</au><au>Chalabi, Nivine</au><au>Hanafy, Hanan Mohamed</au><au>Othman, Amal Ibrahim Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of FDG-PET/CT in fever of unknown origin</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2022-03-01</date><risdate>2022</risdate><volume>53</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><artnum>55</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background Fever of unknown origin (FUO) is a challenging clinical problem in medicine that needs collaboration of various diagnostic techniques to establish the accurate diagnosis. We evaluated the diagnostic performance of 18F-FDG PET/CT in patients who presented themselves with FUO. Our study included 40 patients with FUO who underwent PET/CT examination and their results were compared to the results of laboratory, histopathological, microbiological investigations and/or response to therapy. Results The final diagnosis included malignancy in 20 patients (50%), infectious causes in 7 patients (17.5%) and non-infectious inflammatory causes in 6 patients (15%). Fever resolved without diagnosis in 4 patients (10%), while no definite diagnosis was reached in 3 patients (7%). PET/CT successfully contributed to diagnosis of 35 out of 40 patients with diagnostic accuracy of 87.5%. The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT in our study were 93.5%, 66.7%, 90.6% and 75%, respectively. Conclusion PET/CT is a useful tool to investigate and diagnose the cause of FUO. 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subjects FDG PET/CT
Fever of unknown origin
Imaging
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Nuclear Medicine
PET imaging
Radiology
title Diagnostic value of FDG-PET/CT in fever of unknown origin
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