Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma

While classical Hodgkin lymphoma (HL) is highly susceptible to anti-programmed death protein 1 (PD1) antibodies, the exact modes of action remain controversial. To elucidate the circulating lymphocyte phenotype and systemic effects during anti-PD1 1st-line HL treatment we applied multicolor flow cyt...

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Veröffentlicht in:	Leukemia 2022-03, Vol.36 (3), p.760-771
Hauptverfasser:	Garcia-Marquez, Maria A., Thelen, Martin, Reinke, Sarah, Keller, Diandra, Wennhold, Kerstin, Lehmann, Jonas, Veldman, Johanna, Borchmann, Sven, Rosenwald, Andreas, Sasse, Stephanie, Diepstra, Arjan, Borchmann, Peter, Engert, Andreas, Klapper, Wolfram, von Bergwelt-Baildon, Michael, Bröckelmann, Paul J., Schlößer, Hans A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/31 13/51 38/91 631/250/1619 631/250/251 631/67/1990/291/1556 631/67/580/1884 Antibodies Antigen (tumor-associated) Antigens Antigens, Neoplasm - immunology Apoptosis Cancer Research CD4 antigen Critical Care Medicine Cytotoxicity Effector cells Female Flow cytometry Genotype & phenotype Hematology Hodgkin Disease - drug therapy Hodgkin Disease - immunology Hodgkin's lymphoma Humans Immune Checkpoint Inhibitors - therapeutic use Immunity - drug effects Immunological memory Intensive Interferon Internal Medicine Lymphocytes Lymphocytes T Lymphoma Male Medicine Medicine & Public Health Memory cells Nivolumab - therapeutic use Oncology Patients PD-1 protein Phenotypes T-Lymphocytes - drug effects T-Lymphocytes - immunology Toxicity Tumors
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