Beta-adrenergic receptors gene polymorphisms are associated with cardiac contractility and blood pressure variability
Beta-adrenergic receptors (beta-ARs) play a pivotal role in the cardiovascular regulation. In the human heart beta1- and beta2-ARs dominate in atria as well as in ventricle influencing heart rate and myocardial contractility. Some single nucleotide polymorphisms (SNPs) of beta-ARs might influence ca...
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| Veröffentlicht in: | Physiological research 2021-12, Vol.70 (S3), p.S327-S337 |
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| creator | Matuskova, L Czippelova, B Turianikova, Z Svec, D Kolkova, Z Lasabova, Z Javorka, M |
| description | Beta-adrenergic receptors (beta-ARs) play a pivotal role in the cardiovascular regulation. In the human heart beta1- and beta2-ARs dominate in atria as well as in ventricle influencing heart rate and myocardial contractility. Some single nucleotide polymorphisms (SNPs) of beta-ARs might influence cardiovascular function. However, the influence of beta-AR genes SNPs on hemodynamic parameters at rest and their reactivity under stress is still not well known. We aimed to explore the associations between four selected beta-ARs gene polymorphisms and selected cardiovascular measures in eighty-seven young healthy subjects. While in beta1-AR polymorphism rs1801252 no significant association was observed, second beta1-AR polymorphism rs1801253 was associated with decreased cardiac output and cardiac index during all phases and with decreased flow time corrected and ejection time index at rest and during mental arithmetics. Polymorphism rs1042713 in beta2-AR was associated with alterations in blood pressure variability at rest and during head-up-tilt, while rs1042714 was associated predominantly with decreased parameters of cardiac contractility at rest and during mental arithmetics. We conclude that complex analysis of various cardiovascular characteristics related to the strength of cardiac contraction and blood pressure variability can reveal subtle differences in cardiovascular sympathetic nervous control associated with beta-ARs polymorphisms. |
| doi_str_mv | 10.33549/physiolres.934837 |
| format | Article |
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In the human heart beta1- and beta2-ARs dominate in atria as well as in ventricle influencing heart rate and myocardial contractility. Some single nucleotide polymorphisms (SNPs) of beta-ARs might influence cardiovascular function. However, the influence of beta-AR genes SNPs on hemodynamic parameters at rest and their reactivity under stress is still not well known. We aimed to explore the associations between four selected beta-ARs gene polymorphisms and selected cardiovascular measures in eighty-seven young healthy subjects. While in beta1-AR polymorphism rs1801252 no significant association was observed, second beta1-AR polymorphism rs1801253 was associated with decreased cardiac output and cardiac index during all phases and with decreased flow time corrected and ejection time index at rest and during mental arithmetics. Polymorphism rs1042713 in beta2-AR was associated with alterations in blood pressure variability at rest and during head-up-tilt, while rs1042714 was associated predominantly with decreased parameters of cardiac contractility at rest and during mental arithmetics. We conclude that complex analysis of various cardiovascular characteristics related to the strength of cardiac contraction and blood pressure variability can reveal subtle differences in cardiovascular sympathetic nervous control associated with beta-ARs polymorphisms.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.934837</identifier><identifier>PMID: 35099251</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Adrenergic receptors ; ARS gene ; Blood pressure ; Cardiovascular disease ; Cardiovascular system ; Gene polymorphism ; Heart rate ; Hypertension ; Muscle contraction ; Nervous system ; Polymorphism ; Single-nucleotide polymorphism ; Stroke ; Ventricle</subject><ispartof>Physiological research, 2021-12, Vol.70 (S3), p.S327-S337</ispartof><rights>Copyright Institute of Physiology 2021</rights><rights>2021 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-c5da2b68c10a3e962dbaea36c5d31c41fe9b5c1024de39e15d14173dd6cdcdcf3</citedby><cites>FETCH-LOGICAL-c397t-c5da2b68c10a3e962dbaea36c5d31c41fe9b5c1024de39e15d14173dd6cdcdcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884389/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884389/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35099251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matuskova, L</creatorcontrib><creatorcontrib>Czippelova, B</creatorcontrib><creatorcontrib>Turianikova, Z</creatorcontrib><creatorcontrib>Svec, D</creatorcontrib><creatorcontrib>Kolkova, Z</creatorcontrib><creatorcontrib>Lasabova, Z</creatorcontrib><creatorcontrib>Javorka, M</creatorcontrib><title>Beta-adrenergic receptors gene polymorphisms are associated with cardiac contractility and blood pressure variability</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Beta-adrenergic receptors (beta-ARs) play a pivotal role in the cardiovascular regulation. In the human heart beta1- and beta2-ARs dominate in atria as well as in ventricle influencing heart rate and myocardial contractility. Some single nucleotide polymorphisms (SNPs) of beta-ARs might influence cardiovascular function. However, the influence of beta-AR genes SNPs on hemodynamic parameters at rest and their reactivity under stress is still not well known. We aimed to explore the associations between four selected beta-ARs gene polymorphisms and selected cardiovascular measures in eighty-seven young healthy subjects. While in beta1-AR polymorphism rs1801252 no significant association was observed, second beta1-AR polymorphism rs1801253 was associated with decreased cardiac output and cardiac index during all phases and with decreased flow time corrected and ejection time index at rest and during mental arithmetics. Polymorphism rs1042713 in beta2-AR was associated with alterations in blood pressure variability at rest and during head-up-tilt, while rs1042714 was associated predominantly with decreased parameters of cardiac contractility at rest and during mental arithmetics. We conclude that complex analysis of various cardiovascular characteristics related to the strength of cardiac contraction and blood pressure variability can reveal subtle differences in cardiovascular sympathetic nervous control associated with beta-ARs polymorphisms.</description><subject>Adrenergic receptors</subject><subject>ARS gene</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Gene polymorphism</subject><subject>Heart rate</subject><subject>Hypertension</subject><subject>Muscle contraction</subject><subject>Nervous system</subject><subject>Polymorphism</subject><subject>Single-nucleotide polymorphism</subject><subject>Stroke</subject><subject>Ventricle</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVUclOHDEQtVAiGCb8AIfIUs5NvPRiX5AAsUlIuSRnq9qumTHqaTe2m2j-Pg5DgKgOJdVb6kmPkFPOzqRsav192uySD0PEdKZlrWR3QBZcMVFp3clPZMFUKypVM3VEjlN6ZEx0rJOH5Eg2TGvR8AWZLzFDBS7iiHHtLY1occohJrouJzqFYbcNcdr4tE0UIlJIKVgPGR397fOGWojOg6U2jDmCzX7weUdhdLQfQnB0KvHSXITPED30L_AX8nkFQ8KT170kv26uf17dVQ8_bu-vLh4qK3WXK9s4EH2rLGcgUbfC9YAg23KX3NZ8hbpvCihqh1IjbxyveSeda60rs5JLcr73neZ-i87i34iDmaLfQtyZAN78j4x-Y9bh2Silaql0Mfj2ahDD04wpm8cwx7FkNqIVHdeKF-KSiD3LxpBSxNXbB87MS1XmvSqzr6qIvn7M9ib51438A8MumI4</recordid><startdate>20211231</startdate><enddate>20211231</enddate><creator>Matuskova, L</creator><creator>Czippelova, B</creator><creator>Turianikova, Z</creator><creator>Svec, D</creator><creator>Kolkova, Z</creator><creator>Lasabova, Z</creator><creator>Javorka, M</creator><general>Institute of Physiology</general><general>Institute of Physiology of the Czech Academy of Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20211231</creationdate><title>Beta-adrenergic receptors gene polymorphisms are associated with cardiac contractility and blood pressure variability</title><author>Matuskova, L ; 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In the human heart beta1- and beta2-ARs dominate in atria as well as in ventricle influencing heart rate and myocardial contractility. Some single nucleotide polymorphisms (SNPs) of beta-ARs might influence cardiovascular function. However, the influence of beta-AR genes SNPs on hemodynamic parameters at rest and their reactivity under stress is still not well known. We aimed to explore the associations between four selected beta-ARs gene polymorphisms and selected cardiovascular measures in eighty-seven young healthy subjects. While in beta1-AR polymorphism rs1801252 no significant association was observed, second beta1-AR polymorphism rs1801253 was associated with decreased cardiac output and cardiac index during all phases and with decreased flow time corrected and ejection time index at rest and during mental arithmetics. Polymorphism rs1042713 in beta2-AR was associated with alterations in blood pressure variability at rest and during head-up-tilt, while rs1042714 was associated predominantly with decreased parameters of cardiac contractility at rest and during mental arithmetics. We conclude that complex analysis of various cardiovascular characteristics related to the strength of cardiac contraction and blood pressure variability can reveal subtle differences in cardiovascular sympathetic nervous control associated with beta-ARs polymorphisms.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>35099251</pmid><doi>10.33549/physiolres.934837</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adrenergic receptors ARS gene Blood pressure Cardiovascular disease Cardiovascular system Gene polymorphism Heart rate Hypertension Muscle contraction Nervous system Polymorphism Single-nucleotide polymorphism Stroke Ventricle |
| title | Beta-adrenergic receptors gene polymorphisms are associated with cardiac contractility and blood pressure variability |
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