FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis

Synaptic vesicle (SV) recycling is essential for the maintenance of neurotransmission, with a number of neurodevelopmental disorders linked to defects in this process. Fragile X syndrome (FXS) results from a loss of fragile X mental retardation protein (FMRP) encoded by the gene. Hyperexcitability o...

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Veröffentlicht in:	The Journal of neuroscience 2022-02, Vol.42 (8), p.1618-1628
Hauptverfasser:	Bonnycastle, Katherine, Kind, Peter C, Cousin, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endocytosis FMR1 gene FMR1 protein Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X syndrome Fragile X Syndrome - genetics Fragile X Syndrome - metabolism Intellectual disabilities Large-Conductance Calcium-Activated Potassium Channels - genetics Large-Conductance Calcium-Activated Potassium Channels - metabolism Male Neurodevelopmental disorders Neurons Neurotransmission Neurotransmitter Agents - genetics Neurotransmitter Agents - metabolism Neurotransmitter release Neurotransmitters Potassium channels (calcium-gated) Protein turnover Rats
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