Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human heart failure, whether BRAF promotes cardiomyocyte hyp...

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Veröffentlicht in:	Biochemical journal 2022-02, Vol.479 (3), p.401-424
Hauptverfasser:	Clerk, Angela, Meijles, Daniel N, Hardyman, Michelle A, Fuller, Stephen J, Chothani, Sonia P, Cull, Joshua J, Cooper, Susanna T E, Alharbi, Hajed O, Vanezis, Konstantinos, Felkin, Leanne E, Markou, Thomais, Leonard, Samuel J, Shaw, Spencer W, Rackham, Owen J L, Cook, Stuart A, Glennon, Peter E, Sheppard, Mary N, Sembrat, John C, Rojas, Mauricio, McTiernan, Charles F, Barton, Paul J, Sugden, Peter H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbamates - pharmacology Carbamates - toxicity Cardiomegaly - metabolism Cardiomegaly - pathology Cardiovascular System & Vascular Biology Cell Size - drug effects Cells, Cultured Dimerization Gene Knock-In Techniques Heart Failure - pathology Humans Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Inbred C57BL Mutation, Missense Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Point Mutation Protein Conformation - drug effects Protein Interaction Mapping Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - physiology Proto-Oncogene Proteins c-raf - antagonists & inhibitors Proto-Oncogene Proteins c-raf - biosynthesis Rats Rats, Sprague-Dawley Signaling Sulfonamides - pharmacology Sulfonamides - toxicity
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