Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis
Introduction Onychomycosis is a chronic fungal infection with increasing incidence and the global prevalence is estimated to be 5.5%. The aim of our study was to perceive objectively severity of onychomycosis by calculating Scoring Clinical Index for Onychomycosis and to correlate this index with ac...
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| Veröffentlicht in: | Brazilian journal of microbiology 2022-03, Vol.53 (1), p.221-229 |
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| creator | Dubljanin, Eleonora Dzamic, Aleksandar Vujcic, Isidora Mijatovic, Stefan Crvenkov, Teodora Grujicic, Sandra Sipetic Calovski, Ivana Colovic |
| description | Introduction
Onychomycosis is a chronic fungal infection with increasing incidence and the global prevalence is estimated to be 5.5%. The aim of our study was to perceive objectively severity of onychomycosis by calculating Scoring Clinical Index for Onychomycosis and to correlate this index with accurate laboratory diagnosis in our patients.
Materials and methods
The study population comprised of 417 patients with laboratory confirmed onychomycosis. For each patient, we recorded basic demographic information, site of infection, the most affected nail with onychomycosis, clinical presentation, and type of onychomycosis. The evaluation of the disease severity was based on Scoring Clinical Index for Onychomycosis which was calculated for every patient separately. Mycological identification was done by microscopy and fungal culture.
Results
The majority of patients had distal and lateral subungual onychomycosis (95.44%) that was localized on big toe (62.59%), with female to male ratio 1.24:1. Male patients had significantly more nails affected with onychomycosis compared with female patients (
p
= 0.011), while female had significantly more often onychomycosis on fingernails 2–5 (
p
|
| doi_str_mv | 10.1007/s42770-021-00676-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8882508</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2633992606</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-3f8788f1079c9dc5adf146f8551e53a34990a9e40621104ccb83e798590aadb03</originalsourceid><addsrcrecordid>eNp9kUtv1TAQhSMEoqXwB1ggS2xYNDB-2xskdMWjUqUugLXlOM6Nq1y72Ekh_fX4cksLLFjZOvPNGY9P0zzH8BoDyDeFESmhBYJbACFFe_OgOcZCqpYx4A_rnWPZKqrIUfOklEsAwoGRx80R5QCAiThulk3K2U92DimiNCA3hRicnZAbbbZu9jmUObhyiroVVd0t9-znzdkFCrH3P07R9zCPaB49mmyXsp1TXlEf7DamEsoeTnF1Y9qtbi88bR4Ndir-2e150nz98P7L5lN7fvHxbPPuvHVMsrmlg5JKDRikdrp33PYDZmJQnGPPqaVMa7DaMxAEY2DOdYp6qRWvsu07oCfN24Pv1dLtfO98nLOdzFUOO5tXk2wwf1diGM02XRulVP0rVQ1e3Rrk9G3xZTa7UJyfJht9WoohAiuOlSa6oi__QS_TkmNdr1KUak0EiEqRA-VyKiX74e4xGMw-VXNI1dRUza9UzU1tevHnGnctv2OsAD0ApZbi1uf72f-x_QkF_a_H</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2633992606</pqid></control><display><type>article</type><title>Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Dubljanin, Eleonora ; Dzamic, Aleksandar ; Vujcic, Isidora ; Mijatovic, Stefan ; Crvenkov, Teodora ; Grujicic, Sandra Sipetic ; Calovski, Ivana Colovic</creator><creatorcontrib>Dubljanin, Eleonora ; Dzamic, Aleksandar ; Vujcic, Isidora ; Mijatovic, Stefan ; Crvenkov, Teodora ; Grujicic, Sandra Sipetic ; Calovski, Ivana Colovic</creatorcontrib><description>Introduction
Onychomycosis is a chronic fungal infection with increasing incidence and the global prevalence is estimated to be 5.5%. The aim of our study was to perceive objectively severity of onychomycosis by calculating Scoring Clinical Index for Onychomycosis and to correlate this index with accurate laboratory diagnosis in our patients.
Materials and methods
The study population comprised of 417 patients with laboratory confirmed onychomycosis. For each patient, we recorded basic demographic information, site of infection, the most affected nail with onychomycosis, clinical presentation, and type of onychomycosis. The evaluation of the disease severity was based on Scoring Clinical Index for Onychomycosis which was calculated for every patient separately. Mycological identification was done by microscopy and fungal culture.
Results
The majority of patients had distal and lateral subungual onychomycosis (95.44%) that was localized on big toe (62.59%), with female to male ratio 1.24:1. Male patients had significantly more nails affected with onychomycosis compared with female patients (
p
= 0.011), while female had significantly more often onychomycosis on fingernails 2–5 (
p
< 0.05), and they reported significantly more often pain (
p
< 0.05) and esthetic problems (
p
< 0.05). Mean Scoring Clinical Index for Onychomycosis was 16.76. Dermatophytes were most frequently isolated (91.85%). In patients with onychomycosis caused by dermatophytes, Scoring Clinical Index for Onychomycosis had significantly higher values (
p
= 0.032).
Conclusion
Comprehensive understanding of disease characteristics will allow introduction of individualized treatment plan for each patient, based on proper fungal identification and standardized method of evaluating disease severity, which could help the patient achieve a complete cure.</description><identifier>ISSN: 1517-8382</identifier><identifier>EISSN: 1678-4405</identifier><identifier>DOI: 10.1007/s42770-021-00676-z</identifier><identifier>PMID: 35000126</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biomedical and Life Sciences ; Chronic infection ; Clinical Laboratory Techniques ; Clinical Microbiology - Research Paper ; Diagnosis ; Fingernail ; Food Microbiology ; Fungi ; Humans ; Laboratories ; Life Sciences ; Males ; Mathematical analysis ; Medical Microbiology ; Microbial Ecology ; Microbial Genetics and Genomics ; Microbiology ; Mycology ; Nails - microbiology ; Onychomycosis ; Onychomycosis - diagnosis ; Onychomycosis - drug therapy ; Onychomycosis - epidemiology ; Pain ; Patients ; Population studies ; Prevalence ; Severity of Illness Index</subject><ispartof>Brazilian journal of microbiology, 2022-03, Vol.53 (1), p.221-229</ispartof><rights>Sociedade Brasileira de Microbiologia 2022</rights><rights>2022. Sociedade Brasileira de Microbiologia.</rights><rights>Sociedade Brasileira de Microbiologia 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-3f8788f1079c9dc5adf146f8551e53a34990a9e40621104ccb83e798590aadb03</citedby><cites>FETCH-LOGICAL-c474t-3f8788f1079c9dc5adf146f8551e53a34990a9e40621104ccb83e798590aadb03</cites><orcidid>0000-0002-6484-3192</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882508/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882508/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35000126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubljanin, Eleonora</creatorcontrib><creatorcontrib>Dzamic, Aleksandar</creatorcontrib><creatorcontrib>Vujcic, Isidora</creatorcontrib><creatorcontrib>Mijatovic, Stefan</creatorcontrib><creatorcontrib>Crvenkov, Teodora</creatorcontrib><creatorcontrib>Grujicic, Sandra Sipetic</creatorcontrib><creatorcontrib>Calovski, Ivana Colovic</creatorcontrib><title>Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis</title><title>Brazilian journal of microbiology</title><addtitle>Braz J Microbiol</addtitle><addtitle>Braz J Microbiol</addtitle><description>Introduction
Onychomycosis is a chronic fungal infection with increasing incidence and the global prevalence is estimated to be 5.5%. The aim of our study was to perceive objectively severity of onychomycosis by calculating Scoring Clinical Index for Onychomycosis and to correlate this index with accurate laboratory diagnosis in our patients.
Materials and methods
The study population comprised of 417 patients with laboratory confirmed onychomycosis. For each patient, we recorded basic demographic information, site of infection, the most affected nail with onychomycosis, clinical presentation, and type of onychomycosis. The evaluation of the disease severity was based on Scoring Clinical Index for Onychomycosis which was calculated for every patient separately. Mycological identification was done by microscopy and fungal culture.
Results
The majority of patients had distal and lateral subungual onychomycosis (95.44%) that was localized on big toe (62.59%), with female to male ratio 1.24:1. Male patients had significantly more nails affected with onychomycosis compared with female patients (
p
= 0.011), while female had significantly more often onychomycosis on fingernails 2–5 (
p
< 0.05), and they reported significantly more often pain (
p
< 0.05) and esthetic problems (
p
< 0.05). Mean Scoring Clinical Index for Onychomycosis was 16.76. Dermatophytes were most frequently isolated (91.85%). In patients with onychomycosis caused by dermatophytes, Scoring Clinical Index for Onychomycosis had significantly higher values (
p
= 0.032).
Conclusion
Comprehensive understanding of disease characteristics will allow introduction of individualized treatment plan for each patient, based on proper fungal identification and standardized method of evaluating disease severity, which could help the patient achieve a complete cure.</description><subject>Biomedical and Life Sciences</subject><subject>Chronic infection</subject><subject>Clinical Laboratory Techniques</subject><subject>Clinical Microbiology - Research Paper</subject><subject>Diagnosis</subject><subject>Fingernail</subject><subject>Food Microbiology</subject><subject>Fungi</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Males</subject><subject>Mathematical analysis</subject><subject>Medical Microbiology</subject><subject>Microbial Ecology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mycology</subject><subject>Nails - microbiology</subject><subject>Onychomycosis</subject><subject>Onychomycosis - diagnosis</subject><subject>Onychomycosis - drug therapy</subject><subject>Onychomycosis - epidemiology</subject><subject>Pain</subject><subject>Patients</subject><subject>Population studies</subject><subject>Prevalence</subject><subject>Severity of Illness Index</subject><issn>1517-8382</issn><issn>1678-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhSMEoqXwB1ggS2xYNDB-2xskdMWjUqUugLXlOM6Nq1y72Ekh_fX4cksLLFjZOvPNGY9P0zzH8BoDyDeFESmhBYJbACFFe_OgOcZCqpYx4A_rnWPZKqrIUfOklEsAwoGRx80R5QCAiThulk3K2U92DimiNCA3hRicnZAbbbZu9jmUObhyiroVVd0t9-znzdkFCrH3P07R9zCPaB49mmyXsp1TXlEf7DamEsoeTnF1Y9qtbi88bR4Ndir-2e150nz98P7L5lN7fvHxbPPuvHVMsrmlg5JKDRikdrp33PYDZmJQnGPPqaVMa7DaMxAEY2DOdYp6qRWvsu07oCfN24Pv1dLtfO98nLOdzFUOO5tXk2wwf1diGM02XRulVP0rVQ1e3Rrk9G3xZTa7UJyfJht9WoohAiuOlSa6oi__QS_TkmNdr1KUak0EiEqRA-VyKiX74e4xGMw-VXNI1dRUza9UzU1tevHnGnctv2OsAD0ApZbi1uf72f-x_QkF_a_H</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Dubljanin, Eleonora</creator><creator>Dzamic, Aleksandar</creator><creator>Vujcic, Isidora</creator><creator>Mijatovic, Stefan</creator><creator>Crvenkov, Teodora</creator><creator>Grujicic, Sandra Sipetic</creator><creator>Calovski, Ivana Colovic</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6484-3192</orcidid></search><sort><creationdate>20220301</creationdate><title>Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis</title><author>Dubljanin, Eleonora ; Dzamic, Aleksandar ; Vujcic, Isidora ; Mijatovic, Stefan ; Crvenkov, Teodora ; Grujicic, Sandra Sipetic ; Calovski, Ivana Colovic</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-3f8788f1079c9dc5adf146f8551e53a34990a9e40621104ccb83e798590aadb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical and Life Sciences</topic><topic>Chronic infection</topic><topic>Clinical Laboratory Techniques</topic><topic>Clinical Microbiology - Research Paper</topic><topic>Diagnosis</topic><topic>Fingernail</topic><topic>Food Microbiology</topic><topic>Fungi</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Males</topic><topic>Mathematical analysis</topic><topic>Medical Microbiology</topic><topic>Microbial Ecology</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Mycology</topic><topic>Nails - microbiology</topic><topic>Onychomycosis</topic><topic>Onychomycosis - diagnosis</topic><topic>Onychomycosis - drug therapy</topic><topic>Onychomycosis - epidemiology</topic><topic>Pain</topic><topic>Patients</topic><topic>Population studies</topic><topic>Prevalence</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubljanin, Eleonora</creatorcontrib><creatorcontrib>Dzamic, Aleksandar</creatorcontrib><creatorcontrib>Vujcic, Isidora</creatorcontrib><creatorcontrib>Mijatovic, Stefan</creatorcontrib><creatorcontrib>Crvenkov, Teodora</creatorcontrib><creatorcontrib>Grujicic, Sandra Sipetic</creatorcontrib><creatorcontrib>Calovski, Ivana Colovic</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubljanin, Eleonora</au><au>Dzamic, Aleksandar</au><au>Vujcic, Isidora</au><au>Mijatovic, Stefan</au><au>Crvenkov, Teodora</au><au>Grujicic, Sandra Sipetic</au><au>Calovski, Ivana Colovic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis</atitle><jtitle>Brazilian journal of microbiology</jtitle><stitle>Braz J Microbiol</stitle><addtitle>Braz J Microbiol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>53</volume><issue>1</issue><spage>221</spage><epage>229</epage><pages>221-229</pages><issn>1517-8382</issn><eissn>1678-4405</eissn><abstract>Introduction
Onychomycosis is a chronic fungal infection with increasing incidence and the global prevalence is estimated to be 5.5%. The aim of our study was to perceive objectively severity of onychomycosis by calculating Scoring Clinical Index for Onychomycosis and to correlate this index with accurate laboratory diagnosis in our patients.
Materials and methods
The study population comprised of 417 patients with laboratory confirmed onychomycosis. For each patient, we recorded basic demographic information, site of infection, the most affected nail with onychomycosis, clinical presentation, and type of onychomycosis. The evaluation of the disease severity was based on Scoring Clinical Index for Onychomycosis which was calculated for every patient separately. Mycological identification was done by microscopy and fungal culture.
Results
The majority of patients had distal and lateral subungual onychomycosis (95.44%) that was localized on big toe (62.59%), with female to male ratio 1.24:1. Male patients had significantly more nails affected with onychomycosis compared with female patients (
p
= 0.011), while female had significantly more often onychomycosis on fingernails 2–5 (
p
< 0.05), and they reported significantly more often pain (
p
< 0.05) and esthetic problems (
p
< 0.05). Mean Scoring Clinical Index for Onychomycosis was 16.76. Dermatophytes were most frequently isolated (91.85%). In patients with onychomycosis caused by dermatophytes, Scoring Clinical Index for Onychomycosis had significantly higher values (
p
= 0.032).
Conclusion
Comprehensive understanding of disease characteristics will allow introduction of individualized treatment plan for each patient, based on proper fungal identification and standardized method of evaluating disease severity, which could help the patient achieve a complete cure.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35000126</pmid><doi>10.1007/s42770-021-00676-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6484-3192</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical and Life Sciences Chronic infection Clinical Laboratory Techniques Clinical Microbiology - Research Paper Diagnosis Fingernail Food Microbiology Fungi Humans Laboratories Life Sciences Males Mathematical analysis Medical Microbiology Microbial Ecology Microbial Genetics and Genomics Microbiology Mycology Nails - microbiology Onychomycosis Onychomycosis - diagnosis Onychomycosis - drug therapy Onychomycosis - epidemiology Pain Patients Population studies Prevalence Severity of Illness Index |
| title | Correlation of clinical characteristics, by calculation of SCIO index, with the laboratory diagnosis of onychomycosis |
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