Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and t...
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| Veröffentlicht in: | Lung 2022-02, Vol.200 (1), p.11-18 |
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| creator | Todd, Jamie L. Neely, Megan L. Overton, Robert Mulder, Hillary Roman, Jesse Lasky, Joseph A. de Andrade, Joao A. Gulati, Mridu Huang, Howard Leonard, Thomas B. Hesslinger, Christian Noth, Imre Belperio, John A. Flaherty, Kevin R. Palmer, Scott M. |
| description | Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and the composite outcome of respiratory death or lung transplant. Plasma collected at enrollment was analyzed using aptamer-based proteomics (1305 proteins). Over a median follow-up of 30.4 months, there were 76 respiratory deaths and 26 lung transplants. In unadjusted univariable analyses, 61 proteins were significantly associated with the outcome (hazard ratio > 2 or |
| doi_str_mv | 10.1007/s00408-021-00505-y |
| format | Article |
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p
≤ 0.05). In multivariable analyses, a set of 4 clinical measures and 47 unique proteins predicted the probability of respiratory death or lung transplant with an optimism-corrected C-index of 0.76. Our results suggest that select circulating proteins strongly associate with the risk of mortality in patients with IPF and confer information independent of clinical measures.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-021-00505-y</identifier><identifier>PMID: 35066606</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Aptamers ; Biomarkers ; Care and treatment ; Cohort Studies ; Death ; Fibrosis ; Humans ; Idiopathic Pulmonary Fibrosis ; Lung diseases ; Lung Transplantation ; Lung transplants ; Lungs ; Medical colleges ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Mortality ; Observational studies ; Patients ; Pharmaceutical industry ; Pneumology/Respiratory System ; Prognosis ; Proteins ; Proteomics ; Pulmonary fibrosis ; Registries ; Transplantation of organs, tissues, etc ; Transplants</subject><ispartof>Lung, 2022-02, Vol.200 (1), p.11-18</ispartof><rights>The Author(s) 2022. corrected publication 2022</rights><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s) 2022. corrected publication 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022, corrected publication 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-af5ab46bd40474f0326273dccf1210f52d0a87ca742acb040c489c4be6ebbc4f3</citedby><cites>FETCH-LOGICAL-c610t-af5ab46bd40474f0326273dccf1210f52d0a87ca742acb040c489c4be6ebbc4f3</cites><orcidid>0000-0003-4247-3693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-021-00505-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-021-00505-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35066606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todd, Jamie L.</creatorcontrib><creatorcontrib>Neely, Megan L.</creatorcontrib><creatorcontrib>Overton, Robert</creatorcontrib><creatorcontrib>Mulder, Hillary</creatorcontrib><creatorcontrib>Roman, Jesse</creatorcontrib><creatorcontrib>Lasky, Joseph A.</creatorcontrib><creatorcontrib>de Andrade, Joao A.</creatorcontrib><creatorcontrib>Gulati, Mridu</creatorcontrib><creatorcontrib>Huang, Howard</creatorcontrib><creatorcontrib>Leonard, Thomas B.</creatorcontrib><creatorcontrib>Hesslinger, Christian</creatorcontrib><creatorcontrib>Noth, Imre</creatorcontrib><creatorcontrib>Belperio, John A.</creatorcontrib><creatorcontrib>Flaherty, Kevin R.</creatorcontrib><creatorcontrib>Palmer, Scott M.</creatorcontrib><creatorcontrib>IPF-PRO Registry investigators</creatorcontrib><creatorcontrib>the IPF-PRO Registry investigators</creatorcontrib><title>Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and the composite outcome of respiratory death or lung transplant. Plasma collected at enrollment was analyzed using aptamer-based proteomics (1305 proteins). Over a median follow-up of 30.4 months, there were 76 respiratory deaths and 26 lung transplants. In unadjusted univariable analyses, 61 proteins were significantly associated with the outcome (hazard ratio > 2 or < 0.5, corrected
p
≤ 0.05). In multivariable analyses, a set of 4 clinical measures and 47 unique proteins predicted the probability of respiratory death or lung transplant with an optimism-corrected C-index of 0.76. Our results suggest that select circulating proteins strongly associate with the risk of mortality in patients with IPF and confer information independent of clinical measures.</description><subject>Analysis</subject><subject>Aptamers</subject><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Cohort Studies</subject><subject>Death</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis</subject><subject>Lung diseases</subject><subject>Lung Transplantation</subject><subject>Lung transplants</subject><subject>Lungs</subject><subject>Medical colleges</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Pharmaceutical industry</subject><subject>Pneumology/Respiratory System</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Pulmonary fibrosis</subject><subject>Registries</subject><subject>Transplantation of organs, tissues, etc</subject><subject>Transplants</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9klFr2zAUhc3YWLNuf2APQzAYe3F3Jcuy-zII2bIFAg2lexayLNsqjpRJ9kZ-Rf9yb5asbUYYBhv7fvf4-PgkyVsKFxSg-BQBOJQpMJoC5JCn22fJhPKMpbTI4XkygYzTlCF0lryK8RaAFoLmL5OzLAchBIhJcjeN0WurBusd8Q2Z2aDHHm9dS1bBD8a6SH7boSNfjMKzD2Q54uwmKBc3vXIDsY6scMG44UAuaus3CFtNVmO_9k6FLZnbKvho4w4fOkMWq3m6ur4i16a1cUBg5jsfhtfJi0b10bw5XM-TH_OvN7Pv6fLq22I2XaZaUBhS1eSq4qKqOfCCN5AxwYqs1rqhjEKTsxpUWWhVcKZ0hQloXl5qXhlhqkrzJjtPPu91N2O1NrVG90H1chPsGt1Kr6w8njjbydb_kmVZUsYBBT4eBIL_OZo4yLWN2vQYifFjlGiIoTUuKKLv_0Fv_Rgcfh5SGVqnRQGPVKt6I61rPL5X70TlVFzmwHLGS6TSE1RrnEGT3pnG4uMj_uIEj0dt1lafXPjwZKEzqh-66PtxV5B4DLI9qPG_xmCah_AoyF0_5b6fEvsp__RTbnHp3dPYH1b-FhKBbA9EHLnWhMes_iN7DwVX8OA</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Todd, Jamie L.</creator><creator>Neely, Megan L.</creator><creator>Overton, Robert</creator><creator>Mulder, Hillary</creator><creator>Roman, Jesse</creator><creator>Lasky, Joseph A.</creator><creator>de Andrade, Joao A.</creator><creator>Gulati, Mridu</creator><creator>Huang, Howard</creator><creator>Leonard, Thomas B.</creator><creator>Hesslinger, Christian</creator><creator>Noth, Imre</creator><creator>Belperio, John A.</creator><creator>Flaherty, Kevin R.</creator><creator>Palmer, Scott M.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4247-3693</orcidid></search><sort><creationdate>20220201</creationdate><title>Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort</title><author>Todd, Jamie L. ; 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Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine associations between circulating proteins and the composite outcome of respiratory death or lung transplant. Plasma collected at enrollment was analyzed using aptamer-based proteomics (1305 proteins). Over a median follow-up of 30.4 months, there were 76 respiratory deaths and 26 lung transplants. In unadjusted univariable analyses, 61 proteins were significantly associated with the outcome (hazard ratio > 2 or < 0.5, corrected
p
≤ 0.05). In multivariable analyses, a set of 4 clinical measures and 47 unique proteins predicted the probability of respiratory death or lung transplant with an optimism-corrected C-index of 0.76. Our results suggest that select circulating proteins strongly associate with the risk of mortality in patients with IPF and confer information independent of clinical measures.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35066606</pmid><doi>10.1007/s00408-021-00505-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4247-3693</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Aptamers Biomarkers Care and treatment Cohort Studies Death Fibrosis Humans Idiopathic Pulmonary Fibrosis Lung diseases Lung Transplantation Lung transplants Lungs Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Mortality Observational studies Patients Pharmaceutical industry Pneumology/Respiratory System Prognosis Proteins Proteomics Pulmonary fibrosis Registries Transplantation of organs, tissues, etc Transplants |
| title | Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort |
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