Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in children and infants. To date, there is no effective vaccine available against RSV. Heparan sulfate is a type of glycosaminoglycan that aids in the attachment of the RSV to the host cell membrane via the G...

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Veröffentlicht in:	International journal of molecular sciences 2022-02, Vol.23 (4), p.1950
Hauptverfasser:	Hamza, Abu, Samad, Abdus, Parray, Zahoor Ahmad, Ara, Sajda, Ahmed, Anwar, Almajhdi, Fahad N, Hussain, Tajamul, Islam, Asimul, Parveen, Shama
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino acid substitution Amino Acid Substitution - genetics Amino acids Antibodies Binding Binding sites Calorimetry Calorimetry - methods Cell Line Cell membranes Chemokines CX3C Chemokine Receptor 1 - genetics CX3C Chemokine Receptor 1 - metabolism Cytokines Fluorescence Glycoproteins Glycosaminoglycans GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Heat measurement Heparan sulfate Heparitin Sulfate - metabolism Humans Infections Membrane proteins Molecular docking Molecular Docking Simulation - methods Mutation Mutation - genetics Point mutation Proteins Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Respiratory syncytial virus Respiratory Syncytial Virus Infections - metabolism Respiratory Syncytial Virus, Human - metabolism Respiratory tract diseases Spectrum analysis Spectrum Analysis - methods Structural stability Titration Vaccines Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Virion - genetics Virions Virus Replication - genetics
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