Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme

Synthetic biology enables microbial hosts to produce complex molecules from organisms that are rare or difficult to cultivate, but the structures of these molecules are limited to those formed by reactions of natural enzymes. The integration of artificial metalloenzymes (ArMs) that catalyse unnatura...

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Veröffentlicht in:	Nature chemistry 2021-12, Vol.13 (12), p.1186-1191
Hauptverfasser:	Huang, Jing, Liu, Zhennan, Bloomer, Brandon J., Clark, Douglas S., Mukhopadhyay, Aindrila, Keasling, Jay D., Hartwig, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/60/1167 631/92/603 639/638/77/603 Analytical Chemistry Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry Biology Biosynthesis Catalysis Chemistry Chemistry and Materials Science Chemistry/Food Science Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism E coli Enzymes Escherichia coli - genetics Escherichia coli - metabolism Inorganic Chemistry INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Iridium Iridium - chemistry Mesoporphyrins - chemistry Metabolic Engineering Metabolic networks Microorganisms Natural products Organic Chemistry Physical Chemistry Porphyrins Stereoisomerism Stereoselectivity Sulfolobus solfataricus - enzymology Synthetic biology Terpenes - chemistry Terpenes - metabolism Transportation systems
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