DNA Methylation Mediates EMT Gene Expression in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Due to abundant stroma and extracellular matrix, accompanied by lack of vascularization, pancreatic ductal adenocarcinoma (PDAC) is characterized by severe hypoxia. Epigenetic regulation is likely one of the mechanisms driving hypoxia-induced epithelial-to-mesenchymal transition (EMT), responsible f...

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Veröffentlicht in:	International journal of molecular sciences 2022-02, Vol.23 (4), p.2117
Hauptverfasser:	Urbanova, Maria, Buocikova, Verona, Trnkova, Lenka, Strapcova, Sabina, Kajabova, Viera Horvathova, Melian, Emma Barreto, Novisedlakova, Maria, Tomas, Miroslav, Dubovan, Peter, Earl, Julie, Bizik, Jozef, Svastova, Eliska, Ciernikova, Sona, Smolkova, Bozena
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Adenocarcinoma Biomarkers, Tumor - genetics Cancer Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Chemokines Crosstalk Cytokines Deoxyribonucleic acid Deregulation DNA DNA methylation DNA Methylation - genetics DNA methyltransferase EMT gene Enzymes Epigenesis, Genetic - genetics Epigenetics Epithelial-Mesenchymal Transition - genetics Extracellular matrix Gene expression Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics Gene regulation Gene silencing Genes Growth factors Humans Hypoxia Inflammation Ligands Medical prognosis Mesenchyme Metastasis Mutation Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Polymerase chain reaction Prognosis Stroma Tumor cell lines Tumors Vascularization
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