Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease

A major hallmark of Parkinson's disease (PD) is the fatal destruction of dopaminergic neurons within the . This event is preceded by the formation of Lewy bodies, which are cytoplasmic inclusions composed of α-synuclein protein aggregates. A triad contribution of α-synuclein aggregation, iron a...

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Veröffentlicht in:International journal of molecular sciences 2022-02, Vol.23 (4), p.2378
Hauptverfasser: Boag, Matthew K, Roberts, Angus, Uversky, Vladimir N, Ma, Linlin, Richardson, Des R, Pountney, Dean L
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Sprache:eng
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