DNA-loop-extruding SMC complexes can traverse one another in vivo

Chromosome organization mediated by structural maintenance of chromosomes (SMC) complexes is vital in many organisms. SMC complexes act as motors that extrude DNA loops, but it remains unclear what happens when multiple complexes encounter one another on the same DNA in living cells and how these in...

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Veröffentlicht in:	Nature structural & molecular biology 2021-08, Vol.28 (8), p.642-651
Hauptverfasser:	Brandão, Hugo B., Ren, Zhongqing, Karaboja, Xheni, Mirny, Leonid A., Wang, Xindan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/100/101 631/337/103 631/57/2272 Bacillus subtilis Bacillus subtilis - genetics Bacteria Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Cycle Proteins - metabolism Chromosomal Proteins, Non-Histone - metabolism Chromosomes Conformation Deoxyribonucleic acid DNA DNA, Bacterial - genetics DNA-Binding Proteins - metabolism Eukaryotes Extrusion Genetic aspects Genome, Bacterial - genetics Genomes In vivo methods and tests Life Sciences Membrane Biology Multiprotein Complexes - metabolism Nucleic Acid Conformation Polymers Protein Structure Strains (organisms) Structure Traffic congestion Traffic jams
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