MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection
Malaria is a severe life-threatening disease caused by the bites of parasite-infected female mosquitoes. It remains a significant problem for the most vulnerable children and women. Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. MiRNAs are t...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-02, Vol.19 (4), p.2395 |
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| creator | Kataria, Poonam Surela, Neha Chaudhary, Amrendra Das, Jyoti |
| description | Malaria is a severe life-threatening disease caused by the bites of parasite-infected female
mosquitoes. It remains a significant problem for the most vulnerable children and women. Recent research has helped establish the relationship between microRNAs (miRNAs) and many other diseases. MiRNAs are the class of small non-coding RNAs consisting of 18-23 nucleotides in length that are evolutionarily conserved and regulate gene expression at a post-transcriptional level and play a significant role in various molecular mechanisms such as cell survival, cell proliferation, and differentiation. MiRNAs can help detect malaria infection as the malaria parasite could alter the miRNA expression of the host. These alterations can be diagnosed by the molecular diagnostic tool that can indicate disease. We summarize the current understanding of miRNA during malaria infection. miRNAs can also be used as biomarkers, and initial research has unearthed their potential in diagnosing and managing various diseases such as malaria. |
| doi_str_mv | 10.3390/ijerph19042395 |
| format | Article |
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| subjects | Animals Anopheles - genetics Biomarkers Bites Cell differentiation Cell proliferation Erythrocytes Female Gene expression Host-Parasite Interactions Humans Infections Malaria Malaria - diagnosis Malaria - parasitology MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular modelling Mosquitoes Nucleotides Parasites Post-transcription Review Vector-borne diseases |
| title | MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection |
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