A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon

Dietary signals are known to modulate stemness and tumorigenicity of intestinal progenitors; however, the impact of a high-fat diet (HFD) on the intestinal stem cell (ISC) niche and its association with colorectal cancer remains unclear. Thus, we aimed to investigate how a HFD affects the ISC niche...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2022-01, Vol.13 (4), p.1141-1159
Hauptverfasser:	Kim, Tae-Young, Kim, Seungil, Kim, Yeji, Lee, Yong-Soo, Lee, Sohyeon, Lee, Su-Hyun, Kweon, Mi-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Stem Cells Cancer-Associated Fibroblasts Colon Diet, High-Fat - adverse effects Gut Microbiome Mesenchymal Stromal Cells Mice Mice, Inbred C57BL Neoplasms Original Research RNA, Ribosomal, 16S - genetics Wnt2b
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