The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study
Background Patients with obesity have an increased risk for adverse COVID-19 outcomes. Body mass index (BMI) does not acknowledge the health burden associated this disease. The performance of the Edmonton Obesity Staging System (EOSS), a clinical classification tool that assesses obesity-related com...
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| Veröffentlicht in: | International Journal of Obesity 2022-03, Vol.46 (3), p.661-668 |
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| creator | Rodríguez-Flores, Marcela Goicochea-Turcott, Eduardo W. Mancillas-Adame, Leonardo Garibay-Nieto, Nayely López-Cervantes, Malaquías Rojas-Russell, Mario E. Castro-Porras, Lilia V. Gutiérrez-León, Eduardo Campos-Calderón, Luis F. Pedraza-Escudero, Karen Aguilar-Cuarto, Karina Villanueva-Ortega, Eréndira Hernández-Ruíz, Joselin Guerrero-Avendaño, Guadalupe Monzalvo-Reyes, Sheyla M. García-Rascón, Rafael Gil-Velázquez, Israel N. Cortés-Hernández, Dora E. Granados-Shiroma, Marcela Alvarez-Rodríguez, Brenda G. Cabello-Garza, Martha L. González-Contreras, Zaira L. Picazo-Palencia, Esteban Cerda-Arteaga, Juana M. Pérez-Gómez, Héctor R. Calva-Rodríguez, Roberto Sánchez-Rodríguez, Gerardo Carpio-Vázquez, Leslie D. Dávalos-Herrera, María A. Villatoro-de-Pleitez, Karla M. Suárez-López, Melissa D. Nevárez-Carrillo, María G. Pérez-Alcántara, Karina Mehta, Roopa Diez, Edurne Sandoval Gregg, Edward W. |
| description | Background
Patients with obesity have an increased risk for adverse COVID-19 outcomes. Body mass index (BMI) does not acknowledge the health burden associated this disease. The performance of the Edmonton Obesity Staging System (EOSS), a clinical classification tool that assesses obesity-related comorbidity, is compared with BMI, with respect to adverse COVID-19 outcomes.
Methods
1071 patients were evaluated in 11 COVID-19 hospitals in Mexico. Patients were classified into EOSS stages. Adjusted risk factors for COVID-19 outcomes were calculated and survival analysis for mechanical ventilation and death was carried out according to EOSS stage and BMI category.
Results
The risk for intubation was higher in patients with EOSS stages 2 and 4 (HR 1.42, 95% CI 1.02–1.97 and 2.78, 95% CI 1.83–4.24), and in patients with BMI classes II and III (HR 1.71, 95% CI 1.06–2.74, and 2.62, 95% CI 1.65–4.17). Mortality rates were significantly lower in patients with EOSS stages 0 and 1 (HR 0.62, 95% CI 0.42–0.92) and higher in patients with BMI class III (HR 1.58, 95% CI 1.03–2.42). In patients with a BMI ≥ 25 kg/m
2
, the risk for intubation increased with progressive EOSS stages. Only individuals in BMI class III showed an increased risk for intubation (HR 2.24, 95% CI 1.50–3.34). Mortality risk was increased in EOSS stages 2 and 4 compared to EOSS 0 and 1, and in patients with BMI class II and III, compared to patients with overweight.
Conclusions
EOSS was associated with adverse COVID-19 outcomes, and it distinguished risks beyond BMI. Patients with overweight and obesity in EOSS stages 0 and 1 had a lower risk than patients with normal weight. BMI does not adequately reflect adipose tissue-associated disease, it is not ideal for guiding chronic-disease management. |
| doi_str_mv | 10.1038/s41366-021-01017-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8873002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2616278269</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-9c12b82b69bf7f5215d2736cfec326190b8d4819d5b9fab548dc9deac7e643323</originalsourceid><addsrcrecordid>eNp9kUtvEzEUhS0EomnLH2CBLLFhY-r3gwVSFVqoVCmLFrbWjMeTupoZB9uDlH-Pk5RCWXRl2ee7x-fqAPCW4I8EM32WOWFSIkwJwgQThfQLsCBcSSS4US_BAjOsEBZSHIHjnO8xxkJg-hocsapzwdkCbG7vPJxLGELZwtjDUq8X3RinEie4an3evd-UZh2mNbzZ5uJH2Me05zbJd8GVUMk6uVz9uPqCiIFxLi6OPn-CDRznoQTk_FSSh7nM3fYUvOqbIfs3D-cJ-H55cbv8hq5XX6-W59fIccULMo7QVtNWmrZXvaBEdFQx6XrvGJXE4FZ3XBPTidb0TSu47pzpfOOUl5wxyk7A54PvZm5H3-0jNIPdpDA2aWtjE-xTZQp3dh1_Wa0Vw3hn8OHBIMWfs8_FjiE7PwzN5OOcbU0hqdJUmoq-_w-9j3Oa6nqVYpRrzYyuFD1QLsWck-8fwxBsd4XaQ6G2Fmr3hdrd0Lt_13gc-dNgBdgByFWa1j79_fsZ29_bvaxv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2632488398</pqid></control><display><type>article</type><title>The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Rodríguez-Flores, Marcela ; Goicochea-Turcott, Eduardo W. ; Mancillas-Adame, Leonardo ; Garibay-Nieto, Nayely ; López-Cervantes, Malaquías ; Rojas-Russell, Mario E. ; Castro-Porras, Lilia V. ; Gutiérrez-León, Eduardo ; Campos-Calderón, Luis F. ; Pedraza-Escudero, Karen ; Aguilar-Cuarto, Karina ; Villanueva-Ortega, Eréndira ; Hernández-Ruíz, Joselin ; Guerrero-Avendaño, Guadalupe ; Monzalvo-Reyes, Sheyla M. ; García-Rascón, Rafael ; Gil-Velázquez, Israel N. ; Cortés-Hernández, Dora E. ; Granados-Shiroma, Marcela ; Alvarez-Rodríguez, Brenda G. ; Cabello-Garza, Martha L. ; González-Contreras, Zaira L. ; Picazo-Palencia, Esteban ; Cerda-Arteaga, Juana M. ; Pérez-Gómez, Héctor R. ; Calva-Rodríguez, Roberto ; Sánchez-Rodríguez, Gerardo ; Carpio-Vázquez, Leslie D. ; Dávalos-Herrera, María A. ; Villatoro-de-Pleitez, Karla M. ; Suárez-López, Melissa D. ; Nevárez-Carrillo, María G. ; Pérez-Alcántara, Karina ; Mehta, Roopa ; Diez, Edurne Sandoval ; Gregg, Edward W.</creator><creatorcontrib>Rodríguez-Flores, Marcela ; Goicochea-Turcott, Eduardo W. ; Mancillas-Adame, Leonardo ; Garibay-Nieto, Nayely ; López-Cervantes, Malaquías ; Rojas-Russell, Mario E. ; Castro-Porras, Lilia V. ; Gutiérrez-León, Eduardo ; Campos-Calderón, Luis F. ; Pedraza-Escudero, Karen ; Aguilar-Cuarto, Karina ; Villanueva-Ortega, Eréndira ; Hernández-Ruíz, Joselin ; Guerrero-Avendaño, Guadalupe ; Monzalvo-Reyes, Sheyla M. ; García-Rascón, Rafael ; Gil-Velázquez, Israel N. ; Cortés-Hernández, Dora E. ; Granados-Shiroma, Marcela ; Alvarez-Rodríguez, Brenda G. ; Cabello-Garza, Martha L. ; González-Contreras, Zaira L. ; Picazo-Palencia, Esteban ; Cerda-Arteaga, Juana M. ; Pérez-Gómez, Héctor R. ; Calva-Rodríguez, Roberto ; Sánchez-Rodríguez, Gerardo ; Carpio-Vázquez, Leslie D. ; Dávalos-Herrera, María A. ; Villatoro-de-Pleitez, Karla M. ; Suárez-López, Melissa D. ; Nevárez-Carrillo, María G. ; Pérez-Alcántara, Karina ; Mehta, Roopa ; Diez, Edurne Sandoval ; Gregg, Edward W.</creatorcontrib><description>Background
Patients with obesity have an increased risk for adverse COVID-19 outcomes. Body mass index (BMI) does not acknowledge the health burden associated this disease. The performance of the Edmonton Obesity Staging System (EOSS), a clinical classification tool that assesses obesity-related comorbidity, is compared with BMI, with respect to adverse COVID-19 outcomes.
Methods
1071 patients were evaluated in 11 COVID-19 hospitals in Mexico. Patients were classified into EOSS stages. Adjusted risk factors for COVID-19 outcomes were calculated and survival analysis for mechanical ventilation and death was carried out according to EOSS stage and BMI category.
Results
The risk for intubation was higher in patients with EOSS stages 2 and 4 (HR 1.42, 95% CI 1.02–1.97 and 2.78, 95% CI 1.83–4.24), and in patients with BMI classes II and III (HR 1.71, 95% CI 1.06–2.74, and 2.62, 95% CI 1.65–4.17). Mortality rates were significantly lower in patients with EOSS stages 0 and 1 (HR 0.62, 95% CI 0.42–0.92) and higher in patients with BMI class III (HR 1.58, 95% CI 1.03–2.42). In patients with a BMI ≥ 25 kg/m
2
, the risk for intubation increased with progressive EOSS stages. Only individuals in BMI class III showed an increased risk for intubation (HR 2.24, 95% CI 1.50–3.34). Mortality risk was increased in EOSS stages 2 and 4 compared to EOSS 0 and 1, and in patients with BMI class II and III, compared to patients with overweight.
Conclusions
EOSS was associated with adverse COVID-19 outcomes, and it distinguished risks beyond BMI. Patients with overweight and obesity in EOSS stages 0 and 1 had a lower risk than patients with normal weight. BMI does not adequately reflect adipose tissue-associated disease, it is not ideal for guiding chronic-disease management.</description><identifier>ISSN: 0307-0565</identifier><identifier>ISSN: 1476-5497</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-021-01017-8</identifier><identifier>PMID: 34974543</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/699/2743/137/773 ; 692/699/2743/393 ; Adipose tissue ; Adult ; Aged ; Body mass index ; Body size ; Body weight ; Chronic illnesses ; Comorbidity ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 - mortality ; Epidemiology ; Female ; Health Promotion and Disease Prevention ; Health risks ; Hospitalization ; Humans ; Internal Medicine ; Intubation ; Male ; Mechanical ventilation ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Mortality ; Mortality risk ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obesity - physiopathology ; Overweight ; Patients ; Public Health ; Retrospective Studies ; Risk analysis ; Risk factors ; Severity of Illness Index ; Survival analysis ; Treatment Outcome</subject><ispartof>International Journal of Obesity, 2022-03, Vol.46 (3), p.661-668</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9c12b82b69bf7f5215d2736cfec326190b8d4819d5b9fab548dc9deac7e643323</citedby><cites>FETCH-LOGICAL-c474t-9c12b82b69bf7f5215d2736cfec326190b8d4819d5b9fab548dc9deac7e643323</cites><orcidid>0000-0002-2509-8054 ; 0000-0002-0571-2563 ; 0000-0001-6580-9650 ; 0000-0001-5833-0932 ; 0000-0002-2456-7955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34974543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Flores, Marcela</creatorcontrib><creatorcontrib>Goicochea-Turcott, Eduardo W.</creatorcontrib><creatorcontrib>Mancillas-Adame, Leonardo</creatorcontrib><creatorcontrib>Garibay-Nieto, Nayely</creatorcontrib><creatorcontrib>López-Cervantes, Malaquías</creatorcontrib><creatorcontrib>Rojas-Russell, Mario E.</creatorcontrib><creatorcontrib>Castro-Porras, Lilia V.</creatorcontrib><creatorcontrib>Gutiérrez-León, Eduardo</creatorcontrib><creatorcontrib>Campos-Calderón, Luis F.</creatorcontrib><creatorcontrib>Pedraza-Escudero, Karen</creatorcontrib><creatorcontrib>Aguilar-Cuarto, Karina</creatorcontrib><creatorcontrib>Villanueva-Ortega, Eréndira</creatorcontrib><creatorcontrib>Hernández-Ruíz, Joselin</creatorcontrib><creatorcontrib>Guerrero-Avendaño, Guadalupe</creatorcontrib><creatorcontrib>Monzalvo-Reyes, Sheyla M.</creatorcontrib><creatorcontrib>García-Rascón, Rafael</creatorcontrib><creatorcontrib>Gil-Velázquez, Israel N.</creatorcontrib><creatorcontrib>Cortés-Hernández, Dora E.</creatorcontrib><creatorcontrib>Granados-Shiroma, Marcela</creatorcontrib><creatorcontrib>Alvarez-Rodríguez, Brenda G.</creatorcontrib><creatorcontrib>Cabello-Garza, Martha L.</creatorcontrib><creatorcontrib>González-Contreras, Zaira L.</creatorcontrib><creatorcontrib>Picazo-Palencia, Esteban</creatorcontrib><creatorcontrib>Cerda-Arteaga, Juana M.</creatorcontrib><creatorcontrib>Pérez-Gómez, Héctor R.</creatorcontrib><creatorcontrib>Calva-Rodríguez, Roberto</creatorcontrib><creatorcontrib>Sánchez-Rodríguez, Gerardo</creatorcontrib><creatorcontrib>Carpio-Vázquez, Leslie D.</creatorcontrib><creatorcontrib>Dávalos-Herrera, María A.</creatorcontrib><creatorcontrib>Villatoro-de-Pleitez, Karla M.</creatorcontrib><creatorcontrib>Suárez-López, Melissa D.</creatorcontrib><creatorcontrib>Nevárez-Carrillo, María G.</creatorcontrib><creatorcontrib>Pérez-Alcántara, Karina</creatorcontrib><creatorcontrib>Mehta, Roopa</creatorcontrib><creatorcontrib>Diez, Edurne Sandoval</creatorcontrib><creatorcontrib>Gregg, Edward W.</creatorcontrib><title>The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background
Patients with obesity have an increased risk for adverse COVID-19 outcomes. Body mass index (BMI) does not acknowledge the health burden associated this disease. The performance of the Edmonton Obesity Staging System (EOSS), a clinical classification tool that assesses obesity-related comorbidity, is compared with BMI, with respect to adverse COVID-19 outcomes.
Methods
1071 patients were evaluated in 11 COVID-19 hospitals in Mexico. Patients were classified into EOSS stages. Adjusted risk factors for COVID-19 outcomes were calculated and survival analysis for mechanical ventilation and death was carried out according to EOSS stage and BMI category.
Results
The risk for intubation was higher in patients with EOSS stages 2 and 4 (HR 1.42, 95% CI 1.02–1.97 and 2.78, 95% CI 1.83–4.24), and in patients with BMI classes II and III (HR 1.71, 95% CI 1.06–2.74, and 2.62, 95% CI 1.65–4.17). Mortality rates were significantly lower in patients with EOSS stages 0 and 1 (HR 0.62, 95% CI 0.42–0.92) and higher in patients with BMI class III (HR 1.58, 95% CI 1.03–2.42). In patients with a BMI ≥ 25 kg/m
2
, the risk for intubation increased with progressive EOSS stages. Only individuals in BMI class III showed an increased risk for intubation (HR 2.24, 95% CI 1.50–3.34). Mortality risk was increased in EOSS stages 2 and 4 compared to EOSS 0 and 1, and in patients with BMI class II and III, compared to patients with overweight.
Conclusions
EOSS was associated with adverse COVID-19 outcomes, and it distinguished risks beyond BMI. Patients with overweight and obesity in EOSS stages 0 and 1 had a lower risk than patients with normal weight. BMI does not adequately reflect adipose tissue-associated disease, it is not ideal for guiding chronic-disease management.</description><subject>692/308/174</subject><subject>692/699/2743/137/773</subject><subject>692/699/2743/393</subject><subject>Adipose tissue</subject><subject>Adult</subject><subject>Aged</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Chronic illnesses</subject><subject>Comorbidity</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - mortality</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health Promotion and Disease Prevention</subject><subject>Health risks</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intubation</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mortality risk</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Obesity - physiopathology</subject><subject>Overweight</subject><subject>Patients</subject><subject>Public Health</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Survival analysis</subject><subject>Treatment 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utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study</title><author>Rodríguez-Flores, Marcela ; Goicochea-Turcott, Eduardo W. ; Mancillas-Adame, Leonardo ; Garibay-Nieto, Nayely ; López-Cervantes, Malaquías ; Rojas-Russell, Mario E. ; Castro-Porras, Lilia V. ; Gutiérrez-León, Eduardo ; Campos-Calderón, Luis F. ; Pedraza-Escudero, Karen ; Aguilar-Cuarto, Karina ; Villanueva-Ortega, Eréndira ; Hernández-Ruíz, Joselin ; Guerrero-Avendaño, Guadalupe ; Monzalvo-Reyes, Sheyla M. ; García-Rascón, Rafael ; Gil-Velázquez, Israel N. ; Cortés-Hernández, Dora E. ; Granados-Shiroma, Marcela ; Alvarez-Rodríguez, Brenda G. ; Cabello-Garza, Martha L. ; González-Contreras, Zaira L. ; Picazo-Palencia, Esteban ; Cerda-Arteaga, Juana M. ; Pérez-Gómez, Héctor R. ; Calva-Rodríguez, Roberto ; Sánchez-Rodríguez, Gerardo ; Carpio-Vázquez, Leslie D. ; Dávalos-Herrera, María A. ; Villatoro-de-Pleitez, Karla M. ; Suárez-López, Melissa D. ; Nevárez-Carrillo, María G. ; Pérez-Alcántara, Karina ; Mehta, Roopa ; Diez, Edurne Sandoval ; Gregg, Edward W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9c12b82b69bf7f5215d2736cfec326190b8d4819d5b9fab548dc9deac7e643323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/308/174</topic><topic>692/699/2743/137/773</topic><topic>692/699/2743/393</topic><topic>Adipose tissue</topic><topic>Adult</topic><topic>Aged</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Chronic illnesses</topic><topic>Comorbidity</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - mortality</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health Promotion and Disease Prevention</topic><topic>Health risks</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intubation</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mortality risk</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Obesity - physiopathology</topic><topic>Overweight</topic><topic>Patients</topic><topic>Public Health</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Survival analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Flores, Marcela</creatorcontrib><creatorcontrib>Goicochea-Turcott, Eduardo W.</creatorcontrib><creatorcontrib>Mancillas-Adame, Leonardo</creatorcontrib><creatorcontrib>Garibay-Nieto, Nayely</creatorcontrib><creatorcontrib>López-Cervantes, Malaquías</creatorcontrib><creatorcontrib>Rojas-Russell, Mario E.</creatorcontrib><creatorcontrib>Castro-Porras, Lilia V.</creatorcontrib><creatorcontrib>Gutiérrez-León, Eduardo</creatorcontrib><creatorcontrib>Campos-Calderón, Luis F.</creatorcontrib><creatorcontrib>Pedraza-Escudero, Karen</creatorcontrib><creatorcontrib>Aguilar-Cuarto, Karina</creatorcontrib><creatorcontrib>Villanueva-Ortega, Eréndira</creatorcontrib><creatorcontrib>Hernández-Ruíz, Joselin</creatorcontrib><creatorcontrib>Guerrero-Avendaño, Guadalupe</creatorcontrib><creatorcontrib>Monzalvo-Reyes, Sheyla M.</creatorcontrib><creatorcontrib>García-Rascón, Rafael</creatorcontrib><creatorcontrib>Gil-Velázquez, Israel N.</creatorcontrib><creatorcontrib>Cortés-Hernández, Dora E.</creatorcontrib><creatorcontrib>Granados-Shiroma, Marcela</creatorcontrib><creatorcontrib>Alvarez-Rodríguez, Brenda G.</creatorcontrib><creatorcontrib>Cabello-Garza, Martha L.</creatorcontrib><creatorcontrib>González-Contreras, Zaira L.</creatorcontrib><creatorcontrib>Picazo-Palencia, Esteban</creatorcontrib><creatorcontrib>Cerda-Arteaga, Juana M.</creatorcontrib><creatorcontrib>Pérez-Gómez, Héctor R.</creatorcontrib><creatorcontrib>Calva-Rodríguez, Roberto</creatorcontrib><creatorcontrib>Sánchez-Rodríguez, Gerardo</creatorcontrib><creatorcontrib>Carpio-Vázquez, Leslie D.</creatorcontrib><creatorcontrib>Dávalos-Herrera, María A.</creatorcontrib><creatorcontrib>Villatoro-de-Pleitez, Karla M.</creatorcontrib><creatorcontrib>Suárez-López, Melissa D.</creatorcontrib><creatorcontrib>Nevárez-Carrillo, María G.</creatorcontrib><creatorcontrib>Pérez-Alcántara, Karina</creatorcontrib><creatorcontrib>Mehta, Roopa</creatorcontrib><creatorcontrib>Diez, Edurne Sandoval</creatorcontrib><creatorcontrib>Gregg, Edward W.</creatorcontrib><collection>Springer Nature OA/Free 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Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Flores, Marcela</au><au>Goicochea-Turcott, Eduardo W.</au><au>Mancillas-Adame, Leonardo</au><au>Garibay-Nieto, Nayely</au><au>López-Cervantes, Malaquías</au><au>Rojas-Russell, Mario E.</au><au>Castro-Porras, Lilia V.</au><au>Gutiérrez-León, Eduardo</au><au>Campos-Calderón, Luis F.</au><au>Pedraza-Escudero, Karen</au><au>Aguilar-Cuarto, Karina</au><au>Villanueva-Ortega, Eréndira</au><au>Hernández-Ruíz, Joselin</au><au>Guerrero-Avendaño, Guadalupe</au><au>Monzalvo-Reyes, Sheyla M.</au><au>García-Rascón, Rafael</au><au>Gil-Velázquez, Israel N.</au><au>Cortés-Hernández, Dora E.</au><au>Granados-Shiroma, Marcela</au><au>Alvarez-Rodríguez, Brenda G.</au><au>Cabello-Garza, Martha L.</au><au>González-Contreras, Zaira L.</au><au>Picazo-Palencia, Esteban</au><au>Cerda-Arteaga, Juana M.</au><au>Pérez-Gómez, Héctor R.</au><au>Calva-Rodríguez, Roberto</au><au>Sánchez-Rodríguez, Gerardo</au><au>Carpio-Vázquez, Leslie D.</au><au>Dávalos-Herrera, María A.</au><au>Villatoro-de-Pleitez, Karla M.</au><au>Suárez-López, Melissa D.</au><au>Nevárez-Carrillo, María G.</au><au>Pérez-Alcántara, Karina</au><au>Mehta, Roopa</au><au>Diez, Edurne Sandoval</au><au>Gregg, Edward W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>46</volume><issue>3</issue><spage>661</spage><epage>668</epage><pages>661-668</pages><issn>0307-0565</issn><issn>1476-5497</issn><eissn>1476-5497</eissn><abstract>Background
Patients with obesity have an increased risk for adverse COVID-19 outcomes. Body mass index (BMI) does not acknowledge the health burden associated this disease. The performance of the Edmonton Obesity Staging System (EOSS), a clinical classification tool that assesses obesity-related comorbidity, is compared with BMI, with respect to adverse COVID-19 outcomes.
Methods
1071 patients were evaluated in 11 COVID-19 hospitals in Mexico. Patients were classified into EOSS stages. Adjusted risk factors for COVID-19 outcomes were calculated and survival analysis for mechanical ventilation and death was carried out according to EOSS stage and BMI category.
Results
The risk for intubation was higher in patients with EOSS stages 2 and 4 (HR 1.42, 95% CI 1.02–1.97 and 2.78, 95% CI 1.83–4.24), and in patients with BMI classes II and III (HR 1.71, 95% CI 1.06–2.74, and 2.62, 95% CI 1.65–4.17). Mortality rates were significantly lower in patients with EOSS stages 0 and 1 (HR 0.62, 95% CI 0.42–0.92) and higher in patients with BMI class III (HR 1.58, 95% CI 1.03–2.42). In patients with a BMI ≥ 25 kg/m
2
, the risk for intubation increased with progressive EOSS stages. Only individuals in BMI class III showed an increased risk for intubation (HR 2.24, 95% CI 1.50–3.34). Mortality risk was increased in EOSS stages 2 and 4 compared to EOSS 0 and 1, and in patients with BMI class II and III, compared to patients with overweight.
Conclusions
EOSS was associated with adverse COVID-19 outcomes, and it distinguished risks beyond BMI. Patients with overweight and obesity in EOSS stages 0 and 1 had a lower risk than patients with normal weight. BMI does not adequately reflect adipose tissue-associated disease, it is not ideal for guiding chronic-disease management.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34974543</pmid><doi>10.1038/s41366-021-01017-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2509-8054</orcidid><orcidid>https://orcid.org/0000-0002-0571-2563</orcidid><orcidid>https://orcid.org/0000-0001-6580-9650</orcidid><orcidid>https://orcid.org/0000-0001-5833-0932</orcidid><orcidid>https://orcid.org/0000-0002-2456-7955</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2022-03, Vol.46 (3), p.661-668 |
| issn | 0307-0565 1476-5497 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8873002 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 692/308/174 692/699/2743/137/773 692/699/2743/393 Adipose tissue Adult Aged Body mass index Body size Body weight Chronic illnesses Comorbidity Coronaviruses COVID-19 COVID-19 - complications COVID-19 - epidemiology COVID-19 - mortality Epidemiology Female Health Promotion and Disease Prevention Health risks Hospitalization Humans Internal Medicine Intubation Male Mechanical ventilation Medicine Medicine & Public Health Metabolic Diseases Middle Aged Mortality Mortality risk Obesity Obesity - complications Obesity - epidemiology Obesity - physiopathology Overweight Patients Public Health Retrospective Studies Risk analysis Risk factors Severity of Illness Index Survival analysis Treatment Outcome |
| title | The utility of the Edmonton Obesity Staging System for the prediction of COVID-19 outcomes: a multi-centre study |
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