Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapses. However how RNA is regulated, and which transcr...

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Veröffentlicht in:	Molecular psychiatry 2021-12, Vol.26 (12), p.7141-7153
Hauptverfasser:	Martinez De La Cruz, Braulio, Markus, Robert, Malla, Sunir, Haig, Maria Isabel, Gell, Chris, Sang, Fei, Bellows, Eleanor, Sherif, Mahmoud Awad, McLean, Denise, Lourdusamy, Anbarasu, Self, Tim, Bodi, Zsuzsanna, Smith, Stuart, Fay, Michael, Macdonald, Ian A., Fray, Rupert, Knight, Helen Miranda
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/1 14/19 14/28 38/90 42/100 45/91 631/208 631/337 631/378 631/80 692/699/476 Behavioral Sciences Biological Psychology Demethylation Glial cells Glutamatergic transmission Hypotheses Localization Medicine Medicine & Public Health N6-methyladenosine Neuronal-glial interactions Neurosciences Parahippocampal gyrus Pharmacotherapy Proteins Psychiatry Ribosomes RNA modification Substantia grisea Synapses Synaptic plasticity
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