A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second most common cause of cancer death in the USA by 2030, yet progress continues to lag behind that of other cancers, with only 9% of patients surviving beyond 5 years. Long-term survivorship of PDAC and improving survival has, unt...
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| Veröffentlicht in: | Cancers 2022-02, Vol.14 (4), p.1020 |
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| creator | Merali, Nabeel Chouari, Tarak Kayani, Kayani Rayner, Charles J Jiménez, José I Krell, Jonathan Giovannetti, Elisa Bagwan, Izhar Relph, Kate Rockall, Timothy A Dhillon, Tony Pandha, Hardev Annels, Nicola E Frampton, Adam E |
| description | Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second most common cause of cancer death in the USA by 2030, yet progress continues to lag behind that of other cancers, with only 9% of patients surviving beyond 5 years. Long-term survivorship of PDAC and improving survival has, until recently, escaped our understanding. One recent frontier in the cancer field is the microbiome. The microbiome collectively refers to the extensive community of bacteria and fungi that colonise us. It is estimated that there is one to ten prokaryotic cells for each human somatic cell, yet, the significance of this community in health and disease has, until recently, been overlooked. This review examines the role of the microbiome in PDAC and how it may alter survival outcomes. We evaluate the possibility of employing microbiomic signatures as biomarkers of PDAC. Ultimately this review analyses whether the microbiome may be amenable to targeting and consequently altering the natural history of PDAC. |
| doi_str_mv | 10.3390/cancers14041020 |
| format | Article |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adenocarcinoma Bacteria Cancer Chemotherapy Gene expression Immunotherapy Medical prognosis Medical research Metabolites Microbiomes Microbiota Microorganisms Pancreas Polyamines Probiotics Review Small intestine Survival Taxonomy |
| title | A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma |
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