Occludin Promotes Adhesion of CD8+ T Cells and Melanocytes in Vitiligo via the HIF-1α Signaling Pathway

Loss of melanocytes induced by activated CD8+ T cells is the pathological hallmark of vitiligo. Melanocyte-specific CD8+ T cells are recruited to the skin via chemokines, thereby releasing perforin, granzyme, and other cytotoxic substances that destroy the melanocytes. However, the mechanism of CD8+...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022-02, Vol.2022, p.6732972-13
Hauptverfasser:	Zou, Puyu, Xiao, Yangfan, Deng, Qiancheng, Shi, Yaqian, You, Ruixuan, Pi, Zixin, Liu, Jiani, Zhan, Yi, Zeng, Qinghai, Zeng, Zhuotong, Xiao, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Adhesion Fibroblasts - metabolism Gene Expression Regulation Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kinases Lymphocytes Melanocytes - metabolism Melanocytes - pathology Occludin - genetics Occludin - metabolism Oxidative Stress Pathogenesis Proteins Signal Transduction Skin - pathology Software Vitiligo Vitiligo - genetics Vitiligo - metabolism Vitiligo - pathology
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