Low bone mass resulting from impaired estrogen signaling in bone increases severity of load-induced osteoarthritis in female mice

Reduced subchondral bone mass and increased remodeling are associated with early stage OA. However, the direct effect of low subchondral bone mass on the risk and severity of OA development is unclear. We sought to determine the role of low bone mass resulting from a bone-specific loss of estrogen s...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2021-11, Vol.152, p.116071-116071, Article 116071
Hauptverfasser:	Ziemian, Sophia N., Ayobami, Olufunmilayo O., Rooney, Amanda M., Kelly, Natalie H., Holyoak, Derek T., Ross, F. Patrick, van der Meulen, Marjolein C.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones Bone Density Cartilage, Articular Disease Models, Animal Estrogen Estrogens Female Mice Osteoarthritis Preclinical studies Subchondral bone Tibia - diagnostic imaging
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!