Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo

Abstract A critical challenge for the successful development of RNA interference-based therapeutics therapeutics has been the enhancement of their in vivo metabolic stability. In therapeutically relevant, fully chemically modified small interfering RNAs (siRNAs), modification of the two terminal pho...

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Veröffentlicht in:	Nucleic acids research 2022-02, Vol.50 (3), p.1221-1240
Hauptverfasser:	Jahns, Hartmut, Taneja, Nate, Willoughby, Jennifer L S, Akabane-Nakata, Masaaki, Brown, Christopher R, Nguyen, Tuyen, Bisbe, Anna, Matsuda, Shigeo, Hettinger, Matt, Manoharan, Rajar M, Rajeev, Kallanthottathil G, Maier, Martin A, Zlatev, Ivan, Charisse, Klaus, Egli, Martin, Manoharan, Muthiah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Biology and Nucleic Acid Chemistry Isomerism Mice Organophosphates RNA Interference RNA Stability RNA, Double-Stranded RNA, Small Interfering - metabolism
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