Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers
Abstract Background The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2022-03, Vol.9 (3), p.ofac030 |
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| creator | Goguet, Emilie Powers, John H Olsen, Cara H Tribble, David R Davies, Julian Illinik, Luca Jackson-Thompson, Belinda M Hollis-Perry, Monique Maiolatesi, Santina E Pollett, Simon Duplessis, Christopher A Wang, Gregory Ramsey, Kathleen F Reyes, Anatalio E Alcorta, Yolanda Wong, Mimi A Ortega, Orlando Parmelee, Edward Lindrose, Alyssa R Moser, Matthew Samuels, Emily C Coggins, Si’Ana A Graydon, Elizabeth Robinson, Sara Campbell, Wesley Malloy, Allison M W Voegtly, Logan J Arnold, Catherine E Cer, Regina Z Malagon, Francisco Bishop-Lilly, Kimberly A Burgess, Timothy H Broder, Christopher C Laing, Eric D Mitre, Edward |
| description | Abstract
Background
The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort of health care workers (HCWs).
Methods
A prospective cohort of HCWs, confirmed negative for SARS-CoV-2 exposure upon enrollment, were evaluated for SARS-CoV-2 infection by monthly analysis of SARS-CoV-2 antibodies as well as referral for polymerase chain reaction testing whenever they exhibited symptoms of coronavirus disease 2019 (COVID-19). Participants completed the standardized and validated FLU-PRO Plus symptom questionnaire scoring viral respiratory disease symptom intensity and frequency at least twice monthly during baseline periods of health and each day they had any symptoms that were different from their baseline.
Results
Two hundred sixty-three participants were enrolled between August 25 and December 31, 2020. Through February 28, 2021, 12 participants were diagnosed with SARS-CoV-2 infection. Symptom analysis demonstrated that all 12 had at least mild symptoms of COVID-19, compared with baseline health, near or at time of infection.
Conclusions
These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus. |
| doi_str_mv | 10.1093/ofid/ofac030 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_TOX</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8860153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A776354882</galeid><oup_id>10.1093/ofid/ofac030</oup_id><sourcerecordid>A776354882</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-20e580e9a169a9ed5ae6cae2c064cf3b8a7b2865a03f53abf430373f4d2ae48b3</originalsourceid><addsrcrecordid>eNp9kd9v1SAUxxujccvcm8-GN32wk0Jp6YvJTTPdkiUarz8eySk97KJt6YDeZP-9XHtd5oshAXL4nE-Ab5a9LOhFQRv-zhnbpwk05fRJdso4k7lsRP300f4kOw_hJ6W0KKigdfM8O-GiaGRV1qdZ_OxdmFFHu0eyCQFDGHGKxBmyvR_n6MZAoiOXexgWiAdkrUK0mmw3X7Z5677njFxP5iBxUyB2IkBat3P-j-YKYYg70oJH8sP5X-jDi-yZgSHg-XE9y759uPzaXuU3nz5et5ubXJeSx5xRFJJiA0XVQIO9AKw0INO0KrXhnYS6Y7ISQLkRHDpTcsprbsqeAZay42fZ-9U7L92IvU4P8zCo2dsR_L1yYNW_J5PdqVu3V1JWtBA8Cd4cBd7dLRiiGm3QOAwwoVuCYlX6ZCpZUyb0YkVvYUBlJ-OSUafR42i1m9DYVN_UdcVFKSVLDW_XBp0SCB7Nw70Kqg7hqkO46hhuwl89fssD_DfKBLxeAbfM_1f9BtrOsG0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2632808294</pqid></control><display><type>article</type><title>Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers</title><source>Oxford Journals Open Access Collection</source><creator>Goguet, Emilie ; Powers, John H ; Olsen, Cara H ; Tribble, David R ; Davies, Julian ; Illinik, Luca ; Jackson-Thompson, Belinda M ; Hollis-Perry, Monique ; Maiolatesi, Santina E ; Pollett, Simon ; Duplessis, Christopher A ; Wang, Gregory ; Ramsey, Kathleen F ; Reyes, Anatalio E ; Alcorta, Yolanda ; Wong, Mimi A ; Ortega, Orlando ; Parmelee, Edward ; Lindrose, Alyssa R ; Moser, Matthew ; Samuels, Emily C ; Coggins, Si’Ana A ; Graydon, Elizabeth ; Robinson, Sara ; Campbell, Wesley ; Malloy, Allison M W ; Voegtly, Logan J ; Arnold, Catherine E ; Cer, Regina Z ; Malagon, Francisco ; Bishop-Lilly, Kimberly A ; Burgess, Timothy H ; Broder, Christopher C ; Laing, Eric D ; Mitre, Edward</creator><creatorcontrib>Goguet, Emilie ; Powers, John H ; Olsen, Cara H ; Tribble, David R ; Davies, Julian ; Illinik, Luca ; Jackson-Thompson, Belinda M ; Hollis-Perry, Monique ; Maiolatesi, Santina E ; Pollett, Simon ; Duplessis, Christopher A ; Wang, Gregory ; Ramsey, Kathleen F ; Reyes, Anatalio E ; Alcorta, Yolanda ; Wong, Mimi A ; Ortega, Orlando ; Parmelee, Edward ; Lindrose, Alyssa R ; Moser, Matthew ; Samuels, Emily C ; Coggins, Si’Ana A ; Graydon, Elizabeth ; Robinson, Sara ; Campbell, Wesley ; Malloy, Allison M W ; Voegtly, Logan J ; Arnold, Catherine E ; Cer, Regina Z ; Malagon, Francisco ; Bishop-Lilly, Kimberly A ; Burgess, Timothy H ; Broder, Christopher C ; Laing, Eric D ; Mitre, Edward</creatorcontrib><description>Abstract
Background
The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort of health care workers (HCWs).
Methods
A prospective cohort of HCWs, confirmed negative for SARS-CoV-2 exposure upon enrollment, were evaluated for SARS-CoV-2 infection by monthly analysis of SARS-CoV-2 antibodies as well as referral for polymerase chain reaction testing whenever they exhibited symptoms of coronavirus disease 2019 (COVID-19). Participants completed the standardized and validated FLU-PRO Plus symptom questionnaire scoring viral respiratory disease symptom intensity and frequency at least twice monthly during baseline periods of health and each day they had any symptoms that were different from their baseline.
Results
Two hundred sixty-three participants were enrolled between August 25 and December 31, 2020. Through February 28, 2021, 12 participants were diagnosed with SARS-CoV-2 infection. Symptom analysis demonstrated that all 12 had at least mild symptoms of COVID-19, compared with baseline health, near or at time of infection.
Conclusions
These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofac030</identifier><identifier>PMID: 35198647</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Analysis ; Antibodies ; Antigen-antibody reactions ; Coronaviruses ; Editor's Choice ; Health aspects ; Influenza ; Lung diseases ; Major ; Medical personnel ; Medical research ; Medicine, Experimental ; Prevalence studies (Epidemiology) ; Severe acute respiratory syndrome ; Viral antibodies ; Workers</subject><ispartof>Open Forum Infectious Diseases, 2022-03, Vol.9 (3), p.ofac030</ispartof><rights>Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022. 2022</rights><rights>Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-20e580e9a169a9ed5ae6cae2c064cf3b8a7b2865a03f53abf430373f4d2ae48b3</citedby><cites>FETCH-LOGICAL-c483t-20e580e9a169a9ed5ae6cae2c064cf3b8a7b2865a03f53abf430373f4d2ae48b3</cites><orcidid>0000-0001-7506-3266 ; 0000-0002-5744-8493 ; 0000-0002-2734-4511 ; 0000-0003-3077-9505 ; 0000-0002-0952-1975 ; 0000-0001-6284-4346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860153/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860153/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/ofid/ofac030$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35198647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goguet, Emilie</creatorcontrib><creatorcontrib>Powers, John H</creatorcontrib><creatorcontrib>Olsen, Cara H</creatorcontrib><creatorcontrib>Tribble, David R</creatorcontrib><creatorcontrib>Davies, Julian</creatorcontrib><creatorcontrib>Illinik, Luca</creatorcontrib><creatorcontrib>Jackson-Thompson, Belinda M</creatorcontrib><creatorcontrib>Hollis-Perry, Monique</creatorcontrib><creatorcontrib>Maiolatesi, Santina E</creatorcontrib><creatorcontrib>Pollett, Simon</creatorcontrib><creatorcontrib>Duplessis, Christopher A</creatorcontrib><creatorcontrib>Wang, Gregory</creatorcontrib><creatorcontrib>Ramsey, Kathleen F</creatorcontrib><creatorcontrib>Reyes, Anatalio E</creatorcontrib><creatorcontrib>Alcorta, Yolanda</creatorcontrib><creatorcontrib>Wong, Mimi A</creatorcontrib><creatorcontrib>Ortega, Orlando</creatorcontrib><creatorcontrib>Parmelee, Edward</creatorcontrib><creatorcontrib>Lindrose, Alyssa R</creatorcontrib><creatorcontrib>Moser, Matthew</creatorcontrib><creatorcontrib>Samuels, Emily C</creatorcontrib><creatorcontrib>Coggins, Si’Ana A</creatorcontrib><creatorcontrib>Graydon, Elizabeth</creatorcontrib><creatorcontrib>Robinson, Sara</creatorcontrib><creatorcontrib>Campbell, Wesley</creatorcontrib><creatorcontrib>Malloy, Allison M W</creatorcontrib><creatorcontrib>Voegtly, Logan J</creatorcontrib><creatorcontrib>Arnold, Catherine E</creatorcontrib><creatorcontrib>Cer, Regina Z</creatorcontrib><creatorcontrib>Malagon, Francisco</creatorcontrib><creatorcontrib>Bishop-Lilly, Kimberly A</creatorcontrib><creatorcontrib>Burgess, Timothy H</creatorcontrib><creatorcontrib>Broder, Christopher C</creatorcontrib><creatorcontrib>Laing, Eric D</creatorcontrib><creatorcontrib>Mitre, Edward</creatorcontrib><title>Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Background
The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort of health care workers (HCWs).
Methods
A prospective cohort of HCWs, confirmed negative for SARS-CoV-2 exposure upon enrollment, were evaluated for SARS-CoV-2 infection by monthly analysis of SARS-CoV-2 antibodies as well as referral for polymerase chain reaction testing whenever they exhibited symptoms of coronavirus disease 2019 (COVID-19). Participants completed the standardized and validated FLU-PRO Plus symptom questionnaire scoring viral respiratory disease symptom intensity and frequency at least twice monthly during baseline periods of health and each day they had any symptoms that were different from their baseline.
Results
Two hundred sixty-three participants were enrolled between August 25 and December 31, 2020. Through February 28, 2021, 12 participants were diagnosed with SARS-CoV-2 infection. Symptom analysis demonstrated that all 12 had at least mild symptoms of COVID-19, compared with baseline health, near or at time of infection.
Conclusions
These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus.</description><subject>Analysis</subject><subject>Antibodies</subject><subject>Antigen-antibody reactions</subject><subject>Coronaviruses</subject><subject>Editor's Choice</subject><subject>Health aspects</subject><subject>Influenza</subject><subject>Lung diseases</subject><subject>Major</subject><subject>Medical personnel</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Severe acute respiratory syndrome</subject><subject>Viral antibodies</subject><subject>Workers</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kd9v1SAUxxujccvcm8-GN32wk0Jp6YvJTTPdkiUarz8eySk97KJt6YDeZP-9XHtd5oshAXL4nE-Ab5a9LOhFQRv-zhnbpwk05fRJdso4k7lsRP300f4kOw_hJ6W0KKigdfM8O-GiaGRV1qdZ_OxdmFFHu0eyCQFDGHGKxBmyvR_n6MZAoiOXexgWiAdkrUK0mmw3X7Z5677njFxP5iBxUyB2IkBat3P-j-YKYYg70oJH8sP5X-jDi-yZgSHg-XE9y759uPzaXuU3nz5et5ubXJeSx5xRFJJiA0XVQIO9AKw0INO0KrXhnYS6Y7ISQLkRHDpTcsprbsqeAZay42fZ-9U7L92IvU4P8zCo2dsR_L1yYNW_J5PdqVu3V1JWtBA8Cd4cBd7dLRiiGm3QOAwwoVuCYlX6ZCpZUyb0YkVvYUBlJ-OSUafR42i1m9DYVN_UdcVFKSVLDW_XBp0SCB7Nw70Kqg7hqkO46hhuwl89fssD_DfKBLxeAbfM_1f9BtrOsG0</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Goguet, Emilie</creator><creator>Powers, John H</creator><creator>Olsen, Cara H</creator><creator>Tribble, David R</creator><creator>Davies, Julian</creator><creator>Illinik, Luca</creator><creator>Jackson-Thompson, Belinda M</creator><creator>Hollis-Perry, Monique</creator><creator>Maiolatesi, Santina E</creator><creator>Pollett, Simon</creator><creator>Duplessis, Christopher A</creator><creator>Wang, Gregory</creator><creator>Ramsey, Kathleen F</creator><creator>Reyes, Anatalio E</creator><creator>Alcorta, Yolanda</creator><creator>Wong, Mimi A</creator><creator>Ortega, Orlando</creator><creator>Parmelee, Edward</creator><creator>Lindrose, Alyssa R</creator><creator>Moser, Matthew</creator><creator>Samuels, Emily C</creator><creator>Coggins, Si’Ana A</creator><creator>Graydon, Elizabeth</creator><creator>Robinson, Sara</creator><creator>Campbell, Wesley</creator><creator>Malloy, Allison M W</creator><creator>Voegtly, Logan J</creator><creator>Arnold, Catherine E</creator><creator>Cer, Regina Z</creator><creator>Malagon, Francisco</creator><creator>Bishop-Lilly, Kimberly A</creator><creator>Burgess, Timothy H</creator><creator>Broder, Christopher C</creator><creator>Laing, Eric D</creator><creator>Mitre, Edward</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7506-3266</orcidid><orcidid>https://orcid.org/0000-0002-5744-8493</orcidid><orcidid>https://orcid.org/0000-0002-2734-4511</orcidid><orcidid>https://orcid.org/0000-0003-3077-9505</orcidid><orcidid>https://orcid.org/0000-0002-0952-1975</orcidid><orcidid>https://orcid.org/0000-0001-6284-4346</orcidid></search><sort><creationdate>20220301</creationdate><title>Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers</title><author>Goguet, Emilie ; Powers, John H ; Olsen, Cara H ; Tribble, David R ; Davies, Julian ; Illinik, Luca ; Jackson-Thompson, Belinda M ; Hollis-Perry, Monique ; Maiolatesi, Santina E ; Pollett, Simon ; Duplessis, Christopher A ; Wang, Gregory ; Ramsey, Kathleen F ; Reyes, Anatalio E ; Alcorta, Yolanda ; Wong, Mimi A ; Ortega, Orlando ; Parmelee, Edward ; Lindrose, Alyssa R ; Moser, Matthew ; Samuels, Emily C ; Coggins, Si’Ana A ; Graydon, Elizabeth ; Robinson, Sara ; Campbell, Wesley ; Malloy, Allison M W ; Voegtly, Logan J ; Arnold, Catherine E ; Cer, Regina Z ; Malagon, Francisco ; Bishop-Lilly, Kimberly A ; Burgess, Timothy H ; Broder, Christopher C ; Laing, Eric D ; Mitre, Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-20e580e9a169a9ed5ae6cae2c064cf3b8a7b2865a03f53abf430373f4d2ae48b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Antibodies</topic><topic>Antigen-antibody reactions</topic><topic>Coronaviruses</topic><topic>Editor's Choice</topic><topic>Health aspects</topic><topic>Influenza</topic><topic>Lung diseases</topic><topic>Major</topic><topic>Medical personnel</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Severe acute respiratory syndrome</topic><topic>Viral antibodies</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goguet, Emilie</creatorcontrib><creatorcontrib>Powers, John H</creatorcontrib><creatorcontrib>Olsen, Cara H</creatorcontrib><creatorcontrib>Tribble, David R</creatorcontrib><creatorcontrib>Davies, Julian</creatorcontrib><creatorcontrib>Illinik, Luca</creatorcontrib><creatorcontrib>Jackson-Thompson, Belinda M</creatorcontrib><creatorcontrib>Hollis-Perry, Monique</creatorcontrib><creatorcontrib>Maiolatesi, Santina E</creatorcontrib><creatorcontrib>Pollett, Simon</creatorcontrib><creatorcontrib>Duplessis, Christopher A</creatorcontrib><creatorcontrib>Wang, Gregory</creatorcontrib><creatorcontrib>Ramsey, Kathleen F</creatorcontrib><creatorcontrib>Reyes, Anatalio E</creatorcontrib><creatorcontrib>Alcorta, Yolanda</creatorcontrib><creatorcontrib>Wong, Mimi A</creatorcontrib><creatorcontrib>Ortega, Orlando</creatorcontrib><creatorcontrib>Parmelee, Edward</creatorcontrib><creatorcontrib>Lindrose, Alyssa R</creatorcontrib><creatorcontrib>Moser, Matthew</creatorcontrib><creatorcontrib>Samuels, Emily C</creatorcontrib><creatorcontrib>Coggins, Si’Ana A</creatorcontrib><creatorcontrib>Graydon, Elizabeth</creatorcontrib><creatorcontrib>Robinson, Sara</creatorcontrib><creatorcontrib>Campbell, Wesley</creatorcontrib><creatorcontrib>Malloy, Allison M W</creatorcontrib><creatorcontrib>Voegtly, Logan J</creatorcontrib><creatorcontrib>Arnold, Catherine E</creatorcontrib><creatorcontrib>Cer, Regina Z</creatorcontrib><creatorcontrib>Malagon, Francisco</creatorcontrib><creatorcontrib>Bishop-Lilly, Kimberly A</creatorcontrib><creatorcontrib>Burgess, Timothy H</creatorcontrib><creatorcontrib>Broder, Christopher C</creatorcontrib><creatorcontrib>Laing, Eric D</creatorcontrib><creatorcontrib>Mitre, Edward</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Goguet, Emilie</au><au>Powers, John H</au><au>Olsen, Cara H</au><au>Tribble, David R</au><au>Davies, Julian</au><au>Illinik, Luca</au><au>Jackson-Thompson, Belinda M</au><au>Hollis-Perry, Monique</au><au>Maiolatesi, Santina E</au><au>Pollett, Simon</au><au>Duplessis, Christopher A</au><au>Wang, Gregory</au><au>Ramsey, Kathleen F</au><au>Reyes, Anatalio E</au><au>Alcorta, Yolanda</au><au>Wong, Mimi A</au><au>Ortega, Orlando</au><au>Parmelee, Edward</au><au>Lindrose, Alyssa R</au><au>Moser, Matthew</au><au>Samuels, Emily C</au><au>Coggins, Si’Ana A</au><au>Graydon, Elizabeth</au><au>Robinson, Sara</au><au>Campbell, Wesley</au><au>Malloy, Allison M W</au><au>Voegtly, Logan J</au><au>Arnold, Catherine E</au><au>Cer, Regina Z</au><au>Malagon, Francisco</au><au>Bishop-Lilly, Kimberly A</au><au>Burgess, Timothy H</au><au>Broder, Christopher C</au><au>Laing, Eric D</au><au>Mitre, Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>9</volume><issue>3</issue><spage>ofac030</spage><pages>ofac030-</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Background
The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort of health care workers (HCWs).
Methods
A prospective cohort of HCWs, confirmed negative for SARS-CoV-2 exposure upon enrollment, were evaluated for SARS-CoV-2 infection by monthly analysis of SARS-CoV-2 antibodies as well as referral for polymerase chain reaction testing whenever they exhibited symptoms of coronavirus disease 2019 (COVID-19). Participants completed the standardized and validated FLU-PRO Plus symptom questionnaire scoring viral respiratory disease symptom intensity and frequency at least twice monthly during baseline periods of health and each day they had any symptoms that were different from their baseline.
Results
Two hundred sixty-three participants were enrolled between August 25 and December 31, 2020. Through February 28, 2021, 12 participants were diagnosed with SARS-CoV-2 infection. Symptom analysis demonstrated that all 12 had at least mild symptoms of COVID-19, compared with baseline health, near or at time of infection.
Conclusions
These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>35198647</pmid><doi>10.1093/ofid/ofac030</doi><orcidid>https://orcid.org/0000-0001-7506-3266</orcidid><orcidid>https://orcid.org/0000-0002-5744-8493</orcidid><orcidid>https://orcid.org/0000-0002-2734-4511</orcidid><orcidid>https://orcid.org/0000-0003-3077-9505</orcidid><orcidid>https://orcid.org/0000-0002-0952-1975</orcidid><orcidid>https://orcid.org/0000-0001-6284-4346</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 2328-8957 |
| ispartof | Open Forum Infectious Diseases, 2022-03, Vol.9 (3), p.ofac030 |
| issn | 2328-8957 2328-8957 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8860153 |
| source | Oxford Journals Open Access Collection |
| subjects | Analysis Antibodies Antigen-antibody reactions Coronaviruses Editor's Choice Health aspects Influenza Lung diseases Major Medical personnel Medical research Medicine, Experimental Prevalence studies (Epidemiology) Severe acute respiratory syndrome Viral antibodies Workers |
| title | Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers |
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