Chronic edible dosing of Δ9-tetrahydrocannabinol (THC) in nonhuman primates reduces systemic platelet activity and function

Cannabis usage has steadily increased as acceptance is growing for both medical and recreational reasons. Medical cannabis is administered for treatment of chronic pain based on the premise that the endocannabinoid system signals desensitize pain sensor neurons and produce anti-inflammatory effects....

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2022-03, Vol.322 (3), p.C370-C381
Hauptverfasser:	Reitsma, Stéphanie E, Lakshmanan, Hari Hara Sudhan, Johnson, Jennifer, Pang, Jiaqing, Parra-Izquierdo, Iván, Melrose, Alex R, Choi, Jaewoo, Anderson, Deirdre E J, Hinds, Monica T, Stevens, Jan Frederik, Aslan, Joseph E, McCarty, Owen J T, Lo, Jamie O
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Blood Coagulation - drug effects Blood platelets Blood Platelets - drug effects Blood Platelets - metabolism Cannabinoid Receptor Agonists - administration & dosage Cannabinoid receptors Cannabis Chronic pain Circulatory system Collagen Dronabinol - administration & dosage Endocannabinoid system Female G protein-coupled receptors Inflammation Lipids Macaca mulatta Male Medical marijuana Medical Marijuana - administration & dosage Oxylipins - blood Patients Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Platelets Secretory Vesicles - drug effects Secretory Vesicles - metabolism Signal Transduction Tetrahydrocannabinol THC Thromboxanes - blood Time Factors
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