Mitochondrial disease manifestations in relation to transcriptome location and function

Localization within the nervous system provides context for neurological disease manifestations and treatment, with numerous disease mechanisms exhibiting predilect locations. In contrast, the molecular function of most disease-causing genes is generally considered dissociated from such brain region...

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Veröffentlicht in:	Molecular genetics and metabolism 2022-01, Vol.135 (1), p.82-92
Hauptverfasser:	Jakkamsetti, Vikram, Balasubramaniam, Seema, Grover, Nidhi, Pascual, Juan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - metabolism Humans Metabolism Mitochondrial Mitochondrial Diseases - genetics Mitochondrial Diseases - metabolism Neurons Phenotype Transcriptome Transcriptome - genetics
Online-Zugang:	Volltext
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