One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody–Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling

Antibody–drug conjugates (ADCs) are an important class of therapeutic agents that harness the highly specific antigen targeting property of antibodies to deliver toxic drugs for targeted cell killing. Site-specific conjugation methods are highly desirable for constructing homogeneous ADCs that posse...

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Veröffentlicht in:	Bioconjugate chemistry 2021-08, Vol.32 (8), p.1888-1897
Hauptverfasser:	Ou, Chong, Li, Chao, Zhang, Roushu, Yang, Qiang, Zong, Guanghui, Dai, Yuanwei, Francis, Rebecca L, Bournazos, Stylianos, Ravetch, Jeffrey V, Wang, Lai-Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Cell Line, Tumor Cell Survival Chemical compounds Chemical reactions Click Chemistry Conjugates Conjugation Cytotoxicity Glycan Humans Immunoconjugates - chemistry Immunoconjugates - pharmacology Molecular Structure Mutants Pharmacology Polysaccharides - chemistry Reaction time Reagents Receptor, ErbB-2 - immunology Side reactions Stability Substrates Synthesis Tags Toxicity Trastuzumab - chemistry Trastuzumab - metabolism
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