Flavivirus recruits the valosin-containing protein–NPL4 complex to induce stress granule disassembly for efficient viral genome replication

Flaviviruses are human pathogens that can cause severe diseases, such as dengue fever and Japanese encephalitis, which can lead to death. Valosin-containing protein (VCP)/p97, a cellular ATPase associated with diverse cellular activities (AAA-ATPase), is reported to have multiple roles in flavivirus...

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Veröffentlicht in:	The Journal of biological chemistry 2022-03, Vol.298 (3), p.101597-101597, Article 101597
Hauptverfasser:	Arakawa, Masashi, Tabata, Keisuke, Ishida, Kotaro, Kobayashi, Makiko, Arai, Arisa, Ishikawa, Tomohiro, Suzuki, Ryosuke, Takeuchi, Hiroaki, Tripathi, Lokesh P., Mizuguchi, Kenji, Morita, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Encephalitis Virus, Japanese - genetics Encephalitis Virus, Japanese - metabolism Encephalitis Virus, Japanese - physiology Flavivirus - genetics Flavivirus - metabolism Flavivirus - physiology flavivirus replication Genome, Viral Humans NPL4 NS4B Nuclear Proteins - metabolism RNA, Viral - genetics stress granules Stress Granules - genetics Stress Granules - metabolism Valosin Containing Protein - metabolism VCP/p97 Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus Replication - physiology
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