A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening

The main protease (Mpro) and papain‐like protease (PLpro) play critical roles in SARS‐CoV‐2 replication and are promising targets for antiviral inhibitors. The simultaneous visualization of Mpro and PLpro is extremely valuable for SARS‐CoV‐2 detection and rapid inhibitor screening. However, such a c...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-02, Vol.61 (9), p.e202113617-n/a
Hauptverfasser:	Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical compounds Color Coronavirus 3C Proteases - antagonists & inhibitors Coronavirus 3C Proteases - metabolism Coronavirus Papain-Like Proteases - antagonists & inhibitors Coronavirus Papain-Like Proteases - metabolism Energy transfer Fluorescence Fluorescence Resonance Energy Transfer Fluorescent Dyes - chemistry Fluorescent indicators Fluorophores HEK293 Cells Humans Inhibitor Screening Inhibitors Main Protease Papain Papain-Like Protease Protease Protease Inhibitors - pharmacology Proteinase Proteinase inhibitors SARS-CoV-2 SARS-CoV-2 - enzymology Screening Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Simultaneous Visualization Vero cells
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