SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria: Findings of a multicentric nationwide study
Summary Background Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here, we investigated predictive factors for coronavirus disease 2019 (COVID-19) associated mortality in patients with neoplastic diseases treated t...
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| Veröffentlicht in: | Wiener Klinische Wochenschrift 2022-05, Vol.134 (9-10), p.371-376 |
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| creator | Berger, Julia M. Wohlfarth, Phillipp Königsbrügge, Oliver Knaus, Hanna A. Porpaczy, Edit Kaufmann, Hannes Schreiber, Johanna Mrva-Ghukasyan, Tatevik Winder, Thomas Severgnini, Luciano Wolf, Dominik Petzer, Verena Nguyen, Van Anh Weinlich, Georg Öhler, Leopold Wonnerth, Anna Miksovsky, Aurelia Engelhart, Bert Preusser, Matthias Berghoff, Anna S. |
| description | Summary
Background
Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here, we investigated predictive factors for coronavirus disease 2019 (COVID-19) associated mortality in patients with neoplastic diseases treated throughout Austria.
Methods
In this multicentric nationwide cohort study, data on patients with active or previous malignant diseases and SARS-CoV‑2 infections diagnosed between 13 March 2020 and 06 April 2021 were collected. Collected data included the stage of the malignant disease and outcome parameters 30 days after the diagnosis of SARS-CoV‑2 infection.
Results
The cohort consisted of 230 individuals of which 75 (32.6%) patients were diagnosed with hematologic malignancies and 155 (67.4%) with solid tumors. At a median follow-up of 31 days after COVID-19 diagnosis, 38 (16.5%) patients had died due to COVID-19. Compared to survivors, patients who died were older (62.4 vs. 71.4 years,
p
|
| doi_str_mv | 10.1007/s00508-022-02006-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8852912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2629385674</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-e8f55378de427543b6c1c952a450d4d1a3e4672c2e3479a1d8b6b7548de667f63</originalsourceid><addsrcrecordid>eNp9kUtLAzEUhYMotj7-gAvJ0k0070w3Qim-oKD42oY0k6lTZiY1yQj990Zbi25chLs43zm53APACcHnBGN1ETEWuECY0vwwlojsgCGRhCElFdkFQ4w5Q4JRMQAHMS4wZoIrsg8GTBBFGFND8PA0fnxCE_-KKAquMcmVsPUhmaZOK2i6EqbgTGpdl2CZ9VWElQ_Qms66AJcm1VmJsO7guI8p1OYI7FWmie54Mw_By_XV8-QWTe9v7ibjKbJMsIRcUQnBVFE6TpXgbCYtsSNBDRe45CUxzHGpqKWOcTUypCxmcpbBbJBSVZIdgst17rKfta60eY1gGr0MdWvCSntT679KV7_puf_QRSHoiNAccLYJCP69dzHpto7WNY3pnO-jppKOWCGk4hmla9QGH2Nw1fYbgvVXFXpdhc5V6O8qNMmm098Lbi0_t88AWwMxS93cBb3wfejy0f6L_QTNp5RN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2629385674</pqid></control><display><type>article</type><title>SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria: Findings of a multicentric nationwide study</title><source>Springer Nature - Complete Springer Journals</source><creator>Berger, Julia M. ; Wohlfarth, Phillipp ; Königsbrügge, Oliver ; Knaus, Hanna A. ; Porpaczy, Edit ; Kaufmann, Hannes ; Schreiber, Johanna ; Mrva-Ghukasyan, Tatevik ; Winder, Thomas ; Severgnini, Luciano ; Wolf, Dominik ; Petzer, Verena ; Nguyen, Van Anh ; Weinlich, Georg ; Öhler, Leopold ; Wonnerth, Anna ; Miksovsky, Aurelia ; Engelhart, Bert ; Preusser, Matthias ; Berghoff, Anna S.</creator><creatorcontrib>Berger, Julia M. ; Wohlfarth, Phillipp ; Königsbrügge, Oliver ; Knaus, Hanna A. ; Porpaczy, Edit ; Kaufmann, Hannes ; Schreiber, Johanna ; Mrva-Ghukasyan, Tatevik ; Winder, Thomas ; Severgnini, Luciano ; Wolf, Dominik ; Petzer, Verena ; Nguyen, Van Anh ; Weinlich, Georg ; Öhler, Leopold ; Wonnerth, Anna ; Miksovsky, Aurelia ; Engelhart, Bert ; Preusser, Matthias ; Berghoff, Anna S.</creatorcontrib><description>Summary
Background
Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here, we investigated predictive factors for coronavirus disease 2019 (COVID-19) associated mortality in patients with neoplastic diseases treated throughout Austria.
Methods
In this multicentric nationwide cohort study, data on patients with active or previous malignant diseases and SARS-CoV‑2 infections diagnosed between 13 March 2020 and 06 April 2021 were collected. Collected data included the stage of the malignant disease and outcome parameters 30 days after the diagnosis of SARS-CoV‑2 infection.
Results
The cohort consisted of 230 individuals of which 75 (32.6%) patients were diagnosed with hematologic malignancies and 155 (67.4%) with solid tumors. At a median follow-up of 31 days after COVID-19 diagnosis, 38 (16.5%) patients had died due to COVID-19. Compared to survivors, patients who died were older (62.4 vs. 71.4 years,
p
< 0.001) and had a higher ECOG performance status (0.7 vs. 2.43,
p
< 0.001). Furthermore, higher neutrophil counts (64.9% vs. 73.8%,
p
= 0.03), lower lymphocyte counts (21.4% vs. 14%,
p
= 0.006) and lower albumin levels (32.5 g/l vs. 21.6 g/l,
p
< 0.001) were observed to be independent risk factors for adverse outcomes. No association between mortality and systemic antineoplastic therapy was found (
p
> 0.05). In 60.6% of the patients, therapy was postponed due to quarantine requirements or hospital admission.
Conclusion
Mortality of Austrian cancer patients infected with SARS-CoV‑2 is comparable to that of other countries. Furthermore, risk factors associated with higher mortality were evident and similar to the general population. Treatment delays were frequently observed.</description><identifier>ISSN: 0043-5325</identifier><identifier>EISSN: 1613-7671</identifier><identifier>DOI: 10.1007/s00508-022-02006-1</identifier><identifier>PMID: 35171337</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Endocrinology ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Pneumology/Respiratory System</subject><ispartof>Wiener Klinische Wochenschrift, 2022-05, Vol.134 (9-10), p.371-376</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c353t-e8f55378de427543b6c1c952a450d4d1a3e4672c2e3479a1d8b6b7548de667f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00508-022-02006-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00508-022-02006-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35171337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berger, Julia M.</creatorcontrib><creatorcontrib>Wohlfarth, Phillipp</creatorcontrib><creatorcontrib>Königsbrügge, Oliver</creatorcontrib><creatorcontrib>Knaus, Hanna A.</creatorcontrib><creatorcontrib>Porpaczy, Edit</creatorcontrib><creatorcontrib>Kaufmann, Hannes</creatorcontrib><creatorcontrib>Schreiber, Johanna</creatorcontrib><creatorcontrib>Mrva-Ghukasyan, Tatevik</creatorcontrib><creatorcontrib>Winder, Thomas</creatorcontrib><creatorcontrib>Severgnini, Luciano</creatorcontrib><creatorcontrib>Wolf, Dominik</creatorcontrib><creatorcontrib>Petzer, Verena</creatorcontrib><creatorcontrib>Nguyen, Van Anh</creatorcontrib><creatorcontrib>Weinlich, Georg</creatorcontrib><creatorcontrib>Öhler, Leopold</creatorcontrib><creatorcontrib>Wonnerth, Anna</creatorcontrib><creatorcontrib>Miksovsky, Aurelia</creatorcontrib><creatorcontrib>Engelhart, Bert</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><creatorcontrib>Berghoff, Anna S.</creatorcontrib><title>SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria: Findings of a multicentric nationwide study</title><title>Wiener Klinische Wochenschrift</title><addtitle>Wien Klin Wochenschr</addtitle><addtitle>Wien Klin Wochenschr</addtitle><description>Summary
Background
Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here, we investigated predictive factors for coronavirus disease 2019 (COVID-19) associated mortality in patients with neoplastic diseases treated throughout Austria.
Methods
In this multicentric nationwide cohort study, data on patients with active or previous malignant diseases and SARS-CoV‑2 infections diagnosed between 13 March 2020 and 06 April 2021 were collected. Collected data included the stage of the malignant disease and outcome parameters 30 days after the diagnosis of SARS-CoV‑2 infection.
Results
The cohort consisted of 230 individuals of which 75 (32.6%) patients were diagnosed with hematologic malignancies and 155 (67.4%) with solid tumors. At a median follow-up of 31 days after COVID-19 diagnosis, 38 (16.5%) patients had died due to COVID-19. Compared to survivors, patients who died were older (62.4 vs. 71.4 years,
p
< 0.001) and had a higher ECOG performance status (0.7 vs. 2.43,
p
< 0.001). Furthermore, higher neutrophil counts (64.9% vs. 73.8%,
p
= 0.03), lower lymphocyte counts (21.4% vs. 14%,
p
= 0.006) and lower albumin levels (32.5 g/l vs. 21.6 g/l,
p
< 0.001) were observed to be independent risk factors for adverse outcomes. No association between mortality and systemic antineoplastic therapy was found (
p
> 0.05). In 60.6% of the patients, therapy was postponed due to quarantine requirements or hospital admission.
Conclusion
Mortality of Austrian cancer patients infected with SARS-CoV‑2 is comparable to that of other countries. Furthermore, risk factors associated with higher mortality were evident and similar to the general population. Treatment delays were frequently observed.</description><subject>Endocrinology</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Pneumology/Respiratory System</subject><issn>0043-5325</issn><issn>1613-7671</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kUtLAzEUhYMotj7-gAvJ0k0070w3Qim-oKD42oY0k6lTZiY1yQj990Zbi25chLs43zm53APACcHnBGN1ETEWuECY0vwwlojsgCGRhCElFdkFQ4w5Q4JRMQAHMS4wZoIrsg8GTBBFGFND8PA0fnxCE_-KKAquMcmVsPUhmaZOK2i6EqbgTGpdl2CZ9VWElQ_Qms66AJcm1VmJsO7guI8p1OYI7FWmie54Mw_By_XV8-QWTe9v7ibjKbJMsIRcUQnBVFE6TpXgbCYtsSNBDRe45CUxzHGpqKWOcTUypCxmcpbBbJBSVZIdgst17rKfta60eY1gGr0MdWvCSntT679KV7_puf_QRSHoiNAccLYJCP69dzHpto7WNY3pnO-jppKOWCGk4hmla9QGH2Nw1fYbgvVXFXpdhc5V6O8qNMmm098Lbi0_t88AWwMxS93cBb3wfejy0f6L_QTNp5RN</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Berger, Julia M.</creator><creator>Wohlfarth, Phillipp</creator><creator>Königsbrügge, Oliver</creator><creator>Knaus, Hanna A.</creator><creator>Porpaczy, Edit</creator><creator>Kaufmann, Hannes</creator><creator>Schreiber, Johanna</creator><creator>Mrva-Ghukasyan, Tatevik</creator><creator>Winder, Thomas</creator><creator>Severgnini, Luciano</creator><creator>Wolf, Dominik</creator><creator>Petzer, Verena</creator><creator>Nguyen, Van Anh</creator><creator>Weinlich, Georg</creator><creator>Öhler, Leopold</creator><creator>Wonnerth, Anna</creator><creator>Miksovsky, Aurelia</creator><creator>Engelhart, Bert</creator><creator>Preusser, Matthias</creator><creator>Berghoff, Anna S.</creator><general>Springer Vienna</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220501</creationdate><title>SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria</title><author>Berger, Julia M. ; Wohlfarth, Phillipp ; Königsbrügge, Oliver ; Knaus, Hanna A. ; Porpaczy, Edit ; Kaufmann, Hannes ; Schreiber, Johanna ; Mrva-Ghukasyan, Tatevik ; Winder, Thomas ; Severgnini, Luciano ; Wolf, Dominik ; Petzer, Verena ; Nguyen, Van Anh ; Weinlich, Georg ; Öhler, Leopold ; Wonnerth, Anna ; Miksovsky, Aurelia ; Engelhart, Bert ; Preusser, Matthias ; Berghoff, Anna S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-e8f55378de427543b6c1c952a450d4d1a3e4672c2e3479a1d8b6b7548de667f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Endocrinology</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Pneumology/Respiratory System</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berger, Julia M.</creatorcontrib><creatorcontrib>Wohlfarth, Phillipp</creatorcontrib><creatorcontrib>Königsbrügge, Oliver</creatorcontrib><creatorcontrib>Knaus, Hanna A.</creatorcontrib><creatorcontrib>Porpaczy, Edit</creatorcontrib><creatorcontrib>Kaufmann, Hannes</creatorcontrib><creatorcontrib>Schreiber, Johanna</creatorcontrib><creatorcontrib>Mrva-Ghukasyan, Tatevik</creatorcontrib><creatorcontrib>Winder, Thomas</creatorcontrib><creatorcontrib>Severgnini, Luciano</creatorcontrib><creatorcontrib>Wolf, Dominik</creatorcontrib><creatorcontrib>Petzer, Verena</creatorcontrib><creatorcontrib>Nguyen, Van Anh</creatorcontrib><creatorcontrib>Weinlich, Georg</creatorcontrib><creatorcontrib>Öhler, Leopold</creatorcontrib><creatorcontrib>Wonnerth, Anna</creatorcontrib><creatorcontrib>Miksovsky, Aurelia</creatorcontrib><creatorcontrib>Engelhart, Bert</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><creatorcontrib>Berghoff, Anna S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiener Klinische Wochenschrift</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berger, Julia M.</au><au>Wohlfarth, Phillipp</au><au>Königsbrügge, Oliver</au><au>Knaus, Hanna A.</au><au>Porpaczy, Edit</au><au>Kaufmann, Hannes</au><au>Schreiber, Johanna</au><au>Mrva-Ghukasyan, Tatevik</au><au>Winder, Thomas</au><au>Severgnini, Luciano</au><au>Wolf, Dominik</au><au>Petzer, Verena</au><au>Nguyen, Van Anh</au><au>Weinlich, Georg</au><au>Öhler, Leopold</au><au>Wonnerth, Anna</au><au>Miksovsky, Aurelia</au><au>Engelhart, Bert</au><au>Preusser, Matthias</au><au>Berghoff, Anna S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria: Findings of a multicentric nationwide study</atitle><jtitle>Wiener Klinische Wochenschrift</jtitle><stitle>Wien Klin Wochenschr</stitle><addtitle>Wien Klin Wochenschr</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>134</volume><issue>9-10</issue><spage>371</spage><epage>376</epage><pages>371-376</pages><issn>0043-5325</issn><eissn>1613-7671</eissn><abstract>Summary
Background
Cancer patients infected with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have an increased risk of mortality. Here, we investigated predictive factors for coronavirus disease 2019 (COVID-19) associated mortality in patients with neoplastic diseases treated throughout Austria.
Methods
In this multicentric nationwide cohort study, data on patients with active or previous malignant diseases and SARS-CoV‑2 infections diagnosed between 13 March 2020 and 06 April 2021 were collected. Collected data included the stage of the malignant disease and outcome parameters 30 days after the diagnosis of SARS-CoV‑2 infection.
Results
The cohort consisted of 230 individuals of which 75 (32.6%) patients were diagnosed with hematologic malignancies and 155 (67.4%) with solid tumors. At a median follow-up of 31 days after COVID-19 diagnosis, 38 (16.5%) patients had died due to COVID-19. Compared to survivors, patients who died were older (62.4 vs. 71.4 years,
p
< 0.001) and had a higher ECOG performance status (0.7 vs. 2.43,
p
< 0.001). Furthermore, higher neutrophil counts (64.9% vs. 73.8%,
p
= 0.03), lower lymphocyte counts (21.4% vs. 14%,
p
= 0.006) and lower albumin levels (32.5 g/l vs. 21.6 g/l,
p
< 0.001) were observed to be independent risk factors for adverse outcomes. No association between mortality and systemic antineoplastic therapy was found (
p
> 0.05). In 60.6% of the patients, therapy was postponed due to quarantine requirements or hospital admission.
Conclusion
Mortality of Austrian cancer patients infected with SARS-CoV‑2 is comparable to that of other countries. Furthermore, risk factors associated with higher mortality were evident and similar to the general population. Treatment delays were frequently observed.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>35171337</pmid><doi>10.1007/s00508-022-02006-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0043-5325 1613-7671 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Endocrinology Gastroenterology Internal Medicine Medicine Medicine & Public Health Original Original Article Pneumology/Respiratory System |
| title | SARS-CoV-2-related mortality and treatment delays for cancer patients in Austria: Findings of a multicentric nationwide study |
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