Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML

The reported influence of donor Killer-cell Immunoglobulin-like Receptor (KIR) genes on the outcomes of haematopoietic cell transplantation (HCT) are contradictory, in part due to diversity of disease, donor sources, era and conditioning regimens within and between different studies. Here, we descri...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2020-10, Vol.55 (10), p.1975-1984
Hauptverfasser:	Bultitude, Will P., Schellekens, Jennifer, Szydlo, Richard M., Anthias, Chloe, Cooley, Sarah A., Miller, Jeffrey S., Weisdorf, Daniel J., Shaw, Bronwen E., Roberts, Chrissy h., Garcia-Sepulveda, Christian A., Lee, Julia, Pearce, Rachel M., Wilson, Marie C., Potter, Michael N., Byrne, Jenny L., Russell, Nigel H., MacKinnon, Stephen, Bloor, Adrian J., Patel, Amit, McQuaker, I. Grant, Malladi, Ram, Tholouli, Eleni, Orchard, Kim, Potter, Victoria T., Madrigal, J. Alejandro, Mayor, Neema P., Marsh, Steven G. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/22 45/29 45/77 631/208/2489 631/250/1854/2812 692/308/2056 692/308/575 Acute myeloid leukemia Adult Cell Biology Conditioning Depletion Donors Haplotypes Health aspects Health risks Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Histocompatibility antigen HLA HLA Antigens Humans Infections Internal Medicine Leukemia Leukemia, Myeloid, Acute - therapy Lymphocytes T Medical research Medicine Medicine & Public Health Medicine, Experimental Mortality Neoplasm Recurrence, Local Public Health Receptors, KIR - genetics Retrospective Studies Stem cell transplantation Stem Cells T cells T-Lymphocytes Transplantation Transplants & implants
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