Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis

Background. Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade inflammation, showing an increasing trend. The infiltration of immune cells into adipose tissue has been shown to be an important pathogenic cause of T2DM. The purpose of this study is to use the relevant database to i...

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Veröffentlicht in:	BioMed research international 2022, Vol.2022 (1), p.9920744-9920744
Hauptverfasser:	Zhou, Ji, Zhang, Xiaoyi, Ji, Lixia, Jiang, Guohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adipose tissue Animal models Animals Biomarkers Biomedical research Body fat Databases, Genetic Datasets Development and progression Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - immunology Diet, High-Fat DNA microarrays Enrichment Gene expression Gene Expression Profiling Gene Regulatory Networks Genes Genetic aspects Genetic markers Genotype & phenotype Health aspects Histones - genetics Identification and classification Immune system Immunoregulation Infiltration Inflammation Insulin resistance Interleukin 6 Laboratory animals Lck protein Lymphocytes Metabolism Mice Modules Network analysis Obesity Patients Polymerase chain reaction Protein interaction Proteins Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - genetics RNA-directed DNA polymerase Software packages Statistical analysis TLR9 protein Toll-Like Receptor 9 - genetics Toll-like receptors Type 2 diabetes
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