Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Although DNA damage is intricately linked to metabolism, the metabolic alterations that occur in response to DNA damage are not well understood. We use a DNA repair-deficient model of ERCC1-XPF in to gain insights on how genotoxic stress drives aging. Using multi-omic approach, we discover that nucl...

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Veröffentlicht in:	Science advances 2022-02, Vol.8 (7), p.eabl6083
Hauptverfasser:	Hamsanathan, Shruthi, Anthonymuthu, Tamil, Han, Suhao, Shinglot, Himaly, Siefken, Ella, Sims, Austin, Sen, Payel, Pepper, Hannah L, Snyder, Nathaniel W, Bayir, Hulya, Kagan, Valerian, Gurkar, Aditi U
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedicine and Life Sciences Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism DNA Damage DNA Repair Genetics Histones - metabolism Life Sciences Lipid Metabolism SciAdv r-articles
Online-Zugang:	Volltext
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