Effectiveness of Homologous or Heterologous Covid-19 Boosters in Veterans

Effectiveness of Homologous or Heterologous Covid-19 Boosters in Veterans

In a large Veterans Affairs cohort, heterologous boosters in adenoviral-vector–primed participants were more effective at preventing Covid-19 than homologous boosters. Among mRNA-primed participants, no significant differences in protection were noted between those receiving homologous or heterologo...

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Veröffentlicht in:The New England journal of medicine 2022-04, Vol.386 (14), p.1375-1377
Hauptverfasser: Mayr, Florian B, Talisa, Victor B, Shaikh, Obaid, Yende, Sachin, Butt, Adeel A
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies, Neutralizing
Clinical trials
Coronavirus
Coronaviruses
Correspondence
COVID-19
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - therapeutic use
Humans
Immunization
Immunization, Secondary
Infections
Infectious Disease
mRNA
mRNA vaccines
Severe acute respiratory syndrome coronavirus 2
Vaccines
Veterans
Viral Infections
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Beschreibung
Zusammenfassung:In a large Veterans Affairs cohort, heterologous boosters in adenoviral-vector–primed participants were more effective at preventing Covid-19 than homologous boosters. Among mRNA-primed participants, no significant differences in protection were noted between those receiving homologous or heterologous boosters.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2200415