Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5

CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. The second reaction is the C17-C20 bond scission, which is strongly dependent on the presence of cy...

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Veröffentlicht in:	Journal of the American Chemical Society 2021-03, Vol.143 (10), p.3729-3733
Hauptverfasser:	Liu, Yilin, Denisov, Ilia G, Sligar, Stephen G, Kincaid, James R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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