Interpretable network-guided epistasis detection

Abstract Background Detecting epistatic interactions at the gene level is essential to understanding the biological mechanisms of complex diseases. Unfortunately, genome-wide interaction association studies involve many statistical challenges that make such detection hard. We propose a multi-step pr...

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Veröffentlicht in:	Gigascience 2022-02, Vol.11
Hauptverfasser:	Duroux, Diane, Climente-González, Héctor, Azencott, Chloé-Agathe, Van Steen, Kristel
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Computer Science Epistasis Epistasis, Genetic Gene expression Gene mapping Gene polymorphism Genome-wide association studies Genome-Wide Association Study - methods Genomes Inflammatory bowel disease Inflammatory bowel diseases Intestine Life sciences Machine Learning Nucleotides Phenotype Polymorphism Polymorphism, Single Nucleotide Quantitative Trait Loci Sciences du vivant Single-nucleotide polymorphism Statistics
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