Neurofilament light chain concentration in an aging population
Background Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies in the normal aging population are lacking. It is, therefore, urgent to identify influencing factors of NF-L concentration in the aging population...
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| Veröffentlicht in: | Aging clinical and experimental research 2022-02, Vol.34 (2), p.331-339 |
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| creator | Ladang, Aurélie Kovacs, Stéphanie Lengelé, Laetitia Locquet, Médéa Reginster, Jean-Yves Bruyère, Olivier Cavalier, Etienne |
| description | Background
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies in the normal aging population are lacking. It is, therefore, urgent to identify influencing factors of NF-L concentration in the aging population.
Method
We assessed NF-L concentration in sera of a large cohort of 409 community-dwelling adults aged over 65 years. We studied the association between NF-L and various physiological factors but also with self-reported comorbidities or life-style habits.
Results
We showed that NF-L concentration in serum was tightly associated with cystatin C concentration (
r
= 0.501,
p
|
| doi_str_mv | 10.1007/s40520-021-02054-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8847291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2619216520</sourcerecordid><originalsourceid>FETCH-LOGICAL-c552t-87f9fa4533c171b733eb96ac73c735dbd24c90f209c28b5497e6a57d8172196b3</originalsourceid><addsrcrecordid>eNp9Uk1v1DAQtRCIlsIf4IAicYFDwJ-xfalUVUCRVnCB88jxOllXXnuxk5Xor8e7KW3pAWksj5_nvRmPB6HXBH8gGMuPhWNBcYspqQsL3t48QadEVkgxop8-8E_Qi1KuMeakHp6jEyYwUR1lp-j8m5tzGnwwWxenJvhxMzV2Y3xsbIq2YtlMPsWmAqba6OPY7NJuDkf4JXo2mFDcq9v9DP38_OnH5VW7-v7l6-XFqrVC0KlVctCD4YIxSyTpJWOu152xklUT635NudV4oFhbqnrBtXSdEXKt6guI7np2hs4X3d3cb916qSvALvutyb8hGQ__3kS_gTHtQSkuqSZVgC0CwbvRQcq9hz09Eo_-HEYwFnoHlHYKaCcJYZX1fmFtHiW7uljBAcOca9JxsT9keHdbYk6_Zlcm2PpiXQgmujSXKkk0JV39sRr69lHodZpzrA2sUVRpTCg9CNIlyuZUSnbDXQUEw2EAYBkAqAMAxwGAm0p687BRd5S_P37fiFKv4ujyfe7_yP4BgZK6Uw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628901221</pqid></control><display><type>article</type><title>Neurofilament light chain concentration in an aging population</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Ladang, Aurélie ; Kovacs, Stéphanie ; Lengelé, Laetitia ; Locquet, Médéa ; Reginster, Jean-Yves ; Bruyère, Olivier ; Cavalier, Etienne</creator><creatorcontrib>Ladang, Aurélie ; Kovacs, Stéphanie ; Lengelé, Laetitia ; Locquet, Médéa ; Reginster, Jean-Yves ; Bruyère, Olivier ; Cavalier, Etienne</creatorcontrib><description>Background
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies in the normal aging population are lacking. It is, therefore, urgent to identify influencing factors of NF-L concentration in the aging population.
Method
We assessed NF-L concentration in sera of a large cohort of 409 community-dwelling adults aged over 65 years. We studied the association between NF-L and various physiological factors but also with self-reported comorbidities or life-style habits.
Results
We showed that NF-L concentration in serum was tightly associated with cystatin C concentration (
r
= 0.501,
p
< 0.0001) and consequently, to the estimated glomerular filtration rate (eGFR) (
r
= − 0.492;
p
< 0.0001). Additionally, NF-L concentration was dependent on age and body mass index (BMI) but not sex. Among the self-reported comorbidities, subjects who reported neurological disorders, cardiovascular diseases or history of fracture had higher NF-L concentration in univariate analysis, whereas it was only the case for subjects who reported neurological disorders in the multivariate analysis. NF-L concentration was also increased when Mini-Mental State Examination (MMSE) was decreased (≤ 25 points) but not when geriatric depression score (GDS) was increased (> 5 points) in both univariate and multivariate analysis. Finally, we are providing reference ranges by age categories for subjects with or without altered renal function.
Conclusion
NF-L concentration in the aging population is not driven by the increasing number of comorbidities or depression. Yet, NF-L blood concentration is dependent on kidney function and NF-L interpretation in patients suffering from renal failure should be taken with caution.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-021-02054-z</identifier><identifier>PMID: 35018623</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Aging ; Biomarkers ; Blood-based biomarkers ; Chemistry ; Chimie ; Geriatrics/Gerontology ; Glomerular Filtration Rate ; Human health sciences ; Humans ; Independent Living ; Intermediate Filaments ; Life Sciences ; Medicine ; Medicine & Public Health ; Mental Status and Dementia Tests ; Multivariate analysis ; Neurological disorders ; Neurology ; NF-L ; Original ; Original Article ; Physical, chemical, mathematical & earth Sciences ; Physique, chimie, mathématiques & sciences de la terre ; Population ; Public health, health care sciences & services ; Reference ranges ; Santé publique, services médicaux & soins de santé ; Sciences de la santé humaine</subject><ispartof>Aging clinical and experimental research, 2022-02, Vol.34 (2), p.331-339</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-87f9fa4533c171b733eb96ac73c735dbd24c90f209c28b5497e6a57d8172196b3</citedby><cites>FETCH-LOGICAL-c552t-87f9fa4533c171b733eb96ac73c735dbd24c90f209c28b5497e6a57d8172196b3</cites><orcidid>0000-0002-5316-3108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-021-02054-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-021-02054-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35018623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04491645$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ladang, Aurélie</creatorcontrib><creatorcontrib>Kovacs, Stéphanie</creatorcontrib><creatorcontrib>Lengelé, Laetitia</creatorcontrib><creatorcontrib>Locquet, Médéa</creatorcontrib><creatorcontrib>Reginster, Jean-Yves</creatorcontrib><creatorcontrib>Bruyère, Olivier</creatorcontrib><creatorcontrib>Cavalier, Etienne</creatorcontrib><title>Neurofilament light chain concentration in an aging population</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies in the normal aging population are lacking. It is, therefore, urgent to identify influencing factors of NF-L concentration in the aging population.
Method
We assessed NF-L concentration in sera of a large cohort of 409 community-dwelling adults aged over 65 years. We studied the association between NF-L and various physiological factors but also with self-reported comorbidities or life-style habits.
Results
We showed that NF-L concentration in serum was tightly associated with cystatin C concentration (
r
= 0.501,
p
< 0.0001) and consequently, to the estimated glomerular filtration rate (eGFR) (
r
= − 0.492;
p
< 0.0001). Additionally, NF-L concentration was dependent on age and body mass index (BMI) but not sex. Among the self-reported comorbidities, subjects who reported neurological disorders, cardiovascular diseases or history of fracture had higher NF-L concentration in univariate analysis, whereas it was only the case for subjects who reported neurological disorders in the multivariate analysis. NF-L concentration was also increased when Mini-Mental State Examination (MMSE) was decreased (≤ 25 points) but not when geriatric depression score (GDS) was increased (> 5 points) in both univariate and multivariate analysis. Finally, we are providing reference ranges by age categories for subjects with or without altered renal function.
Conclusion
NF-L concentration in the aging population is not driven by the increasing number of comorbidities or depression. Yet, NF-L blood concentration is dependent on kidney function and NF-L interpretation in patients suffering from renal failure should be taken with caution.</description><subject>Aged</subject><subject>Aging</subject><subject>Biomarkers</subject><subject>Blood-based biomarkers</subject><subject>Chemistry</subject><subject>Chimie</subject><subject>Geriatrics/Gerontology</subject><subject>Glomerular Filtration Rate</subject><subject>Human health sciences</subject><subject>Humans</subject><subject>Independent Living</subject><subject>Intermediate Filaments</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental Status and Dementia Tests</subject><subject>Multivariate analysis</subject><subject>Neurological disorders</subject><subject>Neurology</subject><subject>NF-L</subject><subject>Original</subject><subject>Original Article</subject><subject>Physical, chemical, mathematical & earth Sciences</subject><subject>Physique, chimie, mathématiques & sciences de la terre</subject><subject>Population</subject><subject>Public health, health care sciences & services</subject><subject>Reference ranges</subject><subject>Santé publique, services médicaux & soins de santé</subject><subject>Sciences de la santé humaine</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9Uk1v1DAQtRCIlsIf4IAicYFDwJ-xfalUVUCRVnCB88jxOllXXnuxk5Xor8e7KW3pAWksj5_nvRmPB6HXBH8gGMuPhWNBcYspqQsL3t48QadEVkgxop8-8E_Qi1KuMeakHp6jEyYwUR1lp-j8m5tzGnwwWxenJvhxMzV2Y3xsbIq2YtlMPsWmAqba6OPY7NJuDkf4JXo2mFDcq9v9DP38_OnH5VW7-v7l6-XFqrVC0KlVctCD4YIxSyTpJWOu152xklUT635NudV4oFhbqnrBtXSdEXKt6guI7np2hs4X3d3cb916qSvALvutyb8hGQ__3kS_gTHtQSkuqSZVgC0CwbvRQcq9hz09Eo_-HEYwFnoHlHYKaCcJYZX1fmFtHiW7uljBAcOca9JxsT9keHdbYk6_Zlcm2PpiXQgmujSXKkk0JV39sRr69lHodZpzrA2sUVRpTCg9CNIlyuZUSnbDXQUEw2EAYBkAqAMAxwGAm0p687BRd5S_P37fiFKv4ujyfe7_yP4BgZK6Uw</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ladang, Aurélie</creator><creator>Kovacs, Stéphanie</creator><creator>Lengelé, Laetitia</creator><creator>Locquet, Médéa</creator><creator>Reginster, Jean-Yves</creator><creator>Bruyère, Olivier</creator><creator>Cavalier, Etienne</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><general>Springer Verlag</general><general>Springer</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>1XC</scope><scope>Q33</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5316-3108</orcidid></search><sort><creationdate>20220201</creationdate><title>Neurofilament light chain concentration in an aging population</title><author>Ladang, Aurélie ; Kovacs, Stéphanie ; Lengelé, Laetitia ; Locquet, Médéa ; Reginster, Jean-Yves ; Bruyère, Olivier ; Cavalier, Etienne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-87f9fa4533c171b733eb96ac73c735dbd24c90f209c28b5497e6a57d8172196b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Biomarkers</topic><topic>Blood-based biomarkers</topic><topic>Chemistry</topic><topic>Chimie</topic><topic>Geriatrics/Gerontology</topic><topic>Glomerular Filtration Rate</topic><topic>Human health sciences</topic><topic>Humans</topic><topic>Independent Living</topic><topic>Intermediate Filaments</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental Status and Dementia Tests</topic><topic>Multivariate analysis</topic><topic>Neurological disorders</topic><topic>Neurology</topic><topic>NF-L</topic><topic>Original</topic><topic>Original Article</topic><topic>Physical, chemical, mathematical & earth Sciences</topic><topic>Physique, chimie, mathématiques & sciences de la terre</topic><topic>Population</topic><topic>Public health, health care sciences & services</topic><topic>Reference ranges</topic><topic>Santé publique, services médicaux & soins de santé</topic><topic>Sciences de la santé humaine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ladang, Aurélie</creatorcontrib><creatorcontrib>Kovacs, Stéphanie</creatorcontrib><creatorcontrib>Lengelé, Laetitia</creatorcontrib><creatorcontrib>Locquet, Médéa</creatorcontrib><creatorcontrib>Reginster, Jean-Yves</creatorcontrib><creatorcontrib>Bruyère, Olivier</creatorcontrib><creatorcontrib>Cavalier, Etienne</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ladang, Aurélie</au><au>Kovacs, Stéphanie</au><au>Lengelé, Laetitia</au><au>Locquet, Médéa</au><au>Reginster, Jean-Yves</au><au>Bruyère, Olivier</au><au>Cavalier, Etienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurofilament light chain concentration in an aging population</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>34</volume><issue>2</issue><spage>331</spage><epage>339</epage><pages>331-339</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Neurofilament light chain (NF-L) concentration is recognized to be modified in neurological diseases and traumatic brain injuries, but studies in the normal aging population are lacking. It is, therefore, urgent to identify influencing factors of NF-L concentration in the aging population.
Method
We assessed NF-L concentration in sera of a large cohort of 409 community-dwelling adults aged over 65 years. We studied the association between NF-L and various physiological factors but also with self-reported comorbidities or life-style habits.
Results
We showed that NF-L concentration in serum was tightly associated with cystatin C concentration (
r
= 0.501,
p
< 0.0001) and consequently, to the estimated glomerular filtration rate (eGFR) (
r
= − 0.492;
p
< 0.0001). Additionally, NF-L concentration was dependent on age and body mass index (BMI) but not sex. Among the self-reported comorbidities, subjects who reported neurological disorders, cardiovascular diseases or history of fracture had higher NF-L concentration in univariate analysis, whereas it was only the case for subjects who reported neurological disorders in the multivariate analysis. NF-L concentration was also increased when Mini-Mental State Examination (MMSE) was decreased (≤ 25 points) but not when geriatric depression score (GDS) was increased (> 5 points) in both univariate and multivariate analysis. Finally, we are providing reference ranges by age categories for subjects with or without altered renal function.
Conclusion
NF-L concentration in the aging population is not driven by the increasing number of comorbidities or depression. Yet, NF-L blood concentration is dependent on kidney function and NF-L interpretation in patients suffering from renal failure should be taken with caution.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35018623</pmid><doi>10.1007/s40520-021-02054-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5316-3108</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aging Biomarkers Blood-based biomarkers Chemistry Chimie Geriatrics/Gerontology Glomerular Filtration Rate Human health sciences Humans Independent Living Intermediate Filaments Life Sciences Medicine Medicine & Public Health Mental Status and Dementia Tests Multivariate analysis Neurological disorders Neurology NF-L Original Original Article Physical, chemical, mathematical & earth Sciences Physique, chimie, mathématiques & sciences de la terre Population Public health, health care sciences & services Reference ranges Santé publique, services médicaux & soins de santé Sciences de la santé humaine |
| title | Neurofilament light chain concentration in an aging population |
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