Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population
BACKGROUND There is little information available on quantitative description of the relationship between urine albumin-to-creatinine ratio (ACR) and 24-h urine protein excretion (24-h UPE). Here, we developed a calculation tool for 24-h UPE using the urine ACR and limited information on the request...
Gespeichert in:
| Veröffentlicht in: | Medical science monitor 2022-02, Vol.28, p.e934307-e934307-10 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e934307-10 |
|---|---|
| container_issue | |
| container_start_page | e934307 |
| container_title | Medical science monitor |
| container_volume | 28 |
| creator | Liu, Xin Zhao, Yonghong Feng, Yunlin |
| description | BACKGROUND There is little information available on quantitative description of the relationship between urine albumin-to-creatinine ratio (ACR) and 24-h urine protein excretion (24-h UPE). Here, we developed a calculation tool for 24-h UPE using the urine ACR and limited information on the request form. MATERIAL AND METHODS This was a retrospective and observational study. All individuals with same-day urine ACR and 24-h UPE tests in Sichuan Provincial People's Hospital from September 1, 2018 to December 31, 2019 were enrolled. Correlation and agreement between urine ACR and 24-h UPE were evaluated using correlation analysis and an intraclass correlation coefficient, respectively. The Durbin-Watson test and ANOVA were used to assess the performance of the calculation tool, and reliability of the prediction equation was evaluated in the validation group using residual error analysis. RESULTS A total of 906 participants were enrolled, including 639 participants in the development group and 267 in the validation group. Natural logarithm transformation was applied to remove skewness. Natural logarithm-transformed urine ACR correlated well with natural-logarithm-transformed 24-h UPE (Pearson coefficient=0.908; P |
| doi_str_mv | 10.12659/MSM.934307 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8845447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2628296111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-4717b05a64e773c88f4805f8619da3e57ac16cda17b5085f141fa2dad5e48e223</originalsourceid><addsrcrecordid>eNpVkdtLwzAYxYMobk6ffJc8CtKZa5u-CGPMC2w41D2HrE23SJtsSSv639tdHPPpC9_55ZyEA8A1Rn1MYp7eT94n_ZQyipIT0MUxoxFNODo9OnfARQifCBERI34OOpRjxhEnXbAehdpUqjbOQldAwqIlnHljNZx6V2tj4eg783qrz4Kxi706KOdNZWxUu2jodXvfbrZvGyNYeFdBZeGLjZ5dWJlalXDqVk25jbkEZ4Uqg77azx6YPY4-hs_R-PXpZTgYRxmlaR2xBCdzxFXMdJLQTIiCCcQLEeM0V1TzRGU4znLVUhwJXmCGC0VylXPNhCaE9sDDznfVzCudZ9rWXpVy5dvv-h_plJH_FWuWcuG-pBCMM5a0Brd7A-_WjQ61rEzIdFkqq10TJImJIGmMMW7Rux2aeReC18UhBiO5LUm2JcldSS19c_yyA_vXCv0FgliOAQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628296111</pqid></control><display><type>article</type><title>Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Liu, Xin ; Zhao, Yonghong ; Feng, Yunlin</creator><creatorcontrib>Liu, Xin ; Zhao, Yonghong ; Feng, Yunlin</creatorcontrib><description>BACKGROUND There is little information available on quantitative description of the relationship between urine albumin-to-creatinine ratio (ACR) and 24-h urine protein excretion (24-h UPE). Here, we developed a calculation tool for 24-h UPE using the urine ACR and limited information on the request form. MATERIAL AND METHODS This was a retrospective and observational study. All individuals with same-day urine ACR and 24-h UPE tests in Sichuan Provincial People's Hospital from September 1, 2018 to December 31, 2019 were enrolled. Correlation and agreement between urine ACR and 24-h UPE were evaluated using correlation analysis and an intraclass correlation coefficient, respectively. The Durbin-Watson test and ANOVA were used to assess the performance of the calculation tool, and reliability of the prediction equation was evaluated in the validation group using residual error analysis. RESULTS A total of 906 participants were enrolled, including 639 participants in the development group and 267 in the validation group. Natural logarithm transformation was applied to remove skewness. Natural logarithm-transformed urine ACR correlated well with natural-logarithm-transformed 24-h UPE (Pearson coefficient=0.908; P<0.001) and the agreement was consistently good (overall ICC=0.938; 95% CI: 0.928-0.947; P<0.001). The multivariable regression model had good performance (R²=0.864) and high accuracy, demonstrated by results of residual error analysis. CONCLUSIONS We provide a practical calculation tool to estimate total protein excretion using urine ACR and readily accessible variables. However, 24-h UPE is still mandatory when proteinuria is over 10 g/day or when most proteinuria may not be of glomerular origin.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.934307</identifier><identifier>PMID: 35145052</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Albuminuria - urine ; China ; Clinical Research ; Creatinine - urine ; Female ; Humans ; Inpatients - statistics & numerical data ; Male ; Middle Aged ; Proteinuria - urine ; Reproducibility of Results ; Retrospective Studies ; Urinalysis - methods</subject><ispartof>Medical science monitor, 2022-02, Vol.28, p.e934307-e934307-10</ispartof><rights>Med Sci Monit, 2022 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845447/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845447/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35145052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Zhao, Yonghong</creatorcontrib><creatorcontrib>Feng, Yunlin</creatorcontrib><title>Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND There is little information available on quantitative description of the relationship between urine albumin-to-creatinine ratio (ACR) and 24-h urine protein excretion (24-h UPE). Here, we developed a calculation tool for 24-h UPE using the urine ACR and limited information on the request form. MATERIAL AND METHODS This was a retrospective and observational study. All individuals with same-day urine ACR and 24-h UPE tests in Sichuan Provincial People's Hospital from September 1, 2018 to December 31, 2019 were enrolled. Correlation and agreement between urine ACR and 24-h UPE were evaluated using correlation analysis and an intraclass correlation coefficient, respectively. The Durbin-Watson test and ANOVA were used to assess the performance of the calculation tool, and reliability of the prediction equation was evaluated in the validation group using residual error analysis. RESULTS A total of 906 participants were enrolled, including 639 participants in the development group and 267 in the validation group. Natural logarithm transformation was applied to remove skewness. Natural logarithm-transformed urine ACR correlated well with natural-logarithm-transformed 24-h UPE (Pearson coefficient=0.908; P<0.001) and the agreement was consistently good (overall ICC=0.938; 95% CI: 0.928-0.947; P<0.001). The multivariable regression model had good performance (R²=0.864) and high accuracy, demonstrated by results of residual error analysis. CONCLUSIONS We provide a practical calculation tool to estimate total protein excretion using urine ACR and readily accessible variables. However, 24-h UPE is still mandatory when proteinuria is over 10 g/day or when most proteinuria may not be of glomerular origin.</description><subject>Albuminuria - urine</subject><subject>China</subject><subject>Clinical Research</subject><subject>Creatinine - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Inpatients - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proteinuria - urine</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Urinalysis - methods</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdtLwzAYxYMobk6ffJc8CtKZa5u-CGPMC2w41D2HrE23SJtsSSv639tdHPPpC9_55ZyEA8A1Rn1MYp7eT94n_ZQyipIT0MUxoxFNODo9OnfARQifCBERI34OOpRjxhEnXbAehdpUqjbOQldAwqIlnHljNZx6V2tj4eg783qrz4Kxi706KOdNZWxUu2jodXvfbrZvGyNYeFdBZeGLjZ5dWJlalXDqVk25jbkEZ4Uqg77azx6YPY4-hs_R-PXpZTgYRxmlaR2xBCdzxFXMdJLQTIiCCcQLEeM0V1TzRGU4znLVUhwJXmCGC0VylXPNhCaE9sDDznfVzCudZ9rWXpVy5dvv-h_plJH_FWuWcuG-pBCMM5a0Brd7A-_WjQ61rEzIdFkqq10TJImJIGmMMW7Rux2aeReC18UhBiO5LUm2JcldSS19c_yyA_vXCv0FgliOAQ</recordid><startdate>20220211</startdate><enddate>20220211</enddate><creator>Liu, Xin</creator><creator>Zhao, Yonghong</creator><creator>Feng, Yunlin</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220211</creationdate><title>Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population</title><author>Liu, Xin ; Zhao, Yonghong ; Feng, Yunlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-4717b05a64e773c88f4805f8619da3e57ac16cda17b5085f141fa2dad5e48e223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Albuminuria - urine</topic><topic>China</topic><topic>Clinical Research</topic><topic>Creatinine - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Inpatients - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proteinuria - urine</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Urinalysis - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Zhao, Yonghong</creatorcontrib><creatorcontrib>Feng, Yunlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xin</au><au>Zhao, Yonghong</au><au>Feng, Yunlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2022-02-11</date><risdate>2022</risdate><volume>28</volume><spage>e934307</spage><epage>e934307-10</epage><pages>e934307-e934307-10</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND There is little information available on quantitative description of the relationship between urine albumin-to-creatinine ratio (ACR) and 24-h urine protein excretion (24-h UPE). Here, we developed a calculation tool for 24-h UPE using the urine ACR and limited information on the request form. MATERIAL AND METHODS This was a retrospective and observational study. All individuals with same-day urine ACR and 24-h UPE tests in Sichuan Provincial People's Hospital from September 1, 2018 to December 31, 2019 were enrolled. Correlation and agreement between urine ACR and 24-h UPE were evaluated using correlation analysis and an intraclass correlation coefficient, respectively. The Durbin-Watson test and ANOVA were used to assess the performance of the calculation tool, and reliability of the prediction equation was evaluated in the validation group using residual error analysis. RESULTS A total of 906 participants were enrolled, including 639 participants in the development group and 267 in the validation group. Natural logarithm transformation was applied to remove skewness. Natural logarithm-transformed urine ACR correlated well with natural-logarithm-transformed 24-h UPE (Pearson coefficient=0.908; P<0.001) and the agreement was consistently good (overall ICC=0.938; 95% CI: 0.928-0.947; P<0.001). The multivariable regression model had good performance (R²=0.864) and high accuracy, demonstrated by results of residual error analysis. CONCLUSIONS We provide a practical calculation tool to estimate total protein excretion using urine ACR and readily accessible variables. However, 24-h UPE is still mandatory when proteinuria is over 10 g/day or when most proteinuria may not be of glomerular origin.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>35145052</pmid><doi>10.12659/MSM.934307</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1643-3750 |
| ispartof | Medical science monitor, 2022-02, Vol.28, p.e934307-e934307-10 |
| issn | 1643-3750 1234-1010 1643-3750 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8845447 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Albuminuria - urine China Clinical Research Creatinine - urine Female Humans Inpatients - statistics & numerical data Male Middle Aged Proteinuria - urine Reproducibility of Results Retrospective Studies Urinalysis - methods |
| title | Estimation of 24-h Urine Protein Excretion Using Urine Albumin-to-Creatinine Ratio from an In-Hospital Population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T12%3A40%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimation%20of%2024-h%20Urine%20Protein%20Excretion%20Using%20Urine%20Albumin-to-Creatinine%20Ratio%20from%20an%20In-Hospital%20Population&rft.jtitle=Medical%20science%20monitor&rft.au=Liu,%20Xin&rft.date=2022-02-11&rft.volume=28&rft.spage=e934307&rft.epage=e934307-10&rft.pages=e934307-e934307-10&rft.issn=1643-3750&rft.eissn=1643-3750&rft_id=info:doi/10.12659/MSM.934307&rft_dat=%3Cproquest_pubme%3E2628296111%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2628296111&rft_id=info:pmid/35145052&rfr_iscdi=true |