Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes

Despite extensive analysis of pRB phosphorylation in vitro , how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb ∆K4 and Rb ∆K7 knock‐in mice, in which either four or all seven phosphorylation sites in the C‐terminal region of pRb, respec...

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