Aggregation Time Machine: A Platform for the Prediction and Optimization of Long-Term Antibody Stability Using Short-Term Kinetic Analysis

Monoclonal antibodies are the fastest growing class of therapeutics. However, aggregation limits their shelf life and can lead to adverse immune responses. Assessment and optimization of the long-term antibody stability are therefore key challenges in the biologic drug development. Here, we present...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-02, Vol.65 (3), p.2623-2632
Hauptverfasser:	Bunc, Marko, Hadži, San, Graf, Christian, Bončina, Matjaž, Lah, Jurij
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Humans Kinetics Protein Aggregates Protein Multimerization Protein Stability Temperature
Online-Zugang:	Volltext
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