A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma
Background Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non‐invasive...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2022-02, Vol.36 (2), p.e24194-n/a |
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| creator | Li, Rongkang Lu, Chong Yang, Weiqiang Zhou, Yaqi Zhong, Jiatao Chen, Xuan Li, Xinji Huang, Guocheng Peng, Xiqi Liu, Kaihao Zhang, Chunduo Hu, Hongyi Lai, Yongqing |
| description | Background
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non‐invasive biomarker for cancer detection.
Methods
The experiment is divided into three stages, namely, the screening stage, the training stage, and the verification stage. We took 54 patients with nasopharyngeal carcinoma and 108 healthy controls as the research objects. We use the receiver‐operating characteristic (ROC) curve and area under the ROC curve (AUC) to evaluate the diagnostic value of miRNA. Finally, a three‐miRNA panel with high diagnostic efficiency was constructed. In addition, we conducted biological information analysis of these miRNAs to explore their functions.
Results
In NPC patients, the expression of five serum miRNAs (miR‐29c‐3p, miR‐143‐5p, miR‐150‐5p, miR‐145‐3p, and miR‐205‐5p) is significantly dysregulated. Among them, the diagnostic value of these three miRNAs (miR‐29c‐3p, AUC = 0.702; miR‐143‐5p, AUC = 0.733; and miR‐205‐5p, AUC = 787) is more prominent. The diagnostic panel constructed by them has a higher diagnostic value (AUC = 0.902). Through the analysis of the TCGA data set, the target gene of the three‐miRNA panel may be KLF7, NRG1, SH3BGRL2, and SYNPO2.
Conclusion
The three‐miRNA panel (miR‐29c‐3p, miR‐143‐5p, and miR‐205‐5p) may become a novel non‐invasive biological marker for nasopharyngeal cancer screening.
Our study showed that a panel of three serum microRNAs may be performed as a novel and non‐invasive biomarker to diagnose nasopharyngeal carcinoma, with AUC = 0.902. And the development of nasopharyngeal carcinoma may relate to the three‐miRNA panel, the further study was needed to do. |
| doi_str_mv | 10.1002/jcla.24194 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8842135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2620078910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4484-bb809212e535cc8a4cec7becafa486a47bca9092bb88fdaffc6706e26852294a3</originalsourceid><addsrcrecordid>eNp90UFr2zAYBmBRNtq022U_YAh2KQW3kizb8mUQwtpthBZGexaflc-JUlvyJHsj_37K0pWth5180MPL6-8l5B1nl5wxcbU1HVwKyWt5RGac1SoTShSvyIwpVWWK8fyEnMa4ZYypmpfH5CQvmFB1Wc_I45wO4LCjvqXjJiDSiGHqaW9N8N9u59SAow3SKeKKQqSDH9GNFjq6srB2Po7W0Mb6HsIjhkhbH6iD6IcNhJ1bY4IGgrEuiTfkdQtdxLdP3zPycP3pfvE5W97dfFnMl5mRUsmsaRSrBRdY5IUxCqRBUzVooAWpSpBVY6BOIjnVrqBtTVmxEkWpCiFqCfkZ-XjIHaamx5VJhQN0egg2tdxpD1b_--LsRq_9D62UFDwvUsD5U0Dw3yeMo-5tNNh16VJ-ilqUgrEq3ZIl-uEF3fopuPR7e6VEIqxK6uKg0lFjDNg-l-FM7zfU-w317w0Tfv93_Wf6Z7QE-AH8tB3u_hOlvy6W80PoL4q3qQk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628210307</pqid></control><display><type>article</type><title>A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Li, Rongkang ; Lu, Chong ; Yang, Weiqiang ; Zhou, Yaqi ; Zhong, Jiatao ; Chen, Xuan ; Li, Xinji ; Huang, Guocheng ; Peng, Xiqi ; Liu, Kaihao ; Zhang, Chunduo ; Hu, Hongyi ; Lai, Yongqing</creator><creatorcontrib>Li, Rongkang ; Lu, Chong ; Yang, Weiqiang ; Zhou, Yaqi ; Zhong, Jiatao ; Chen, Xuan ; Li, Xinji ; Huang, Guocheng ; Peng, Xiqi ; Liu, Kaihao ; Zhang, Chunduo ; Hu, Hongyi ; Lai, Yongqing</creatorcontrib><description>Background
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non‐invasive biomarker for cancer detection.
Methods
The experiment is divided into three stages, namely, the screening stage, the training stage, and the verification stage. We took 54 patients with nasopharyngeal carcinoma and 108 healthy controls as the research objects. We use the receiver‐operating characteristic (ROC) curve and area under the ROC curve (AUC) to evaluate the diagnostic value of miRNA. Finally, a three‐miRNA panel with high diagnostic efficiency was constructed. In addition, we conducted biological information analysis of these miRNAs to explore their functions.
Results
In NPC patients, the expression of five serum miRNAs (miR‐29c‐3p, miR‐143‐5p, miR‐150‐5p, miR‐145‐3p, and miR‐205‐5p) is significantly dysregulated. Among them, the diagnostic value of these three miRNAs (miR‐29c‐3p, AUC = 0.702; miR‐143‐5p, AUC = 0.733; and miR‐205‐5p, AUC = 787) is more prominent. The diagnostic panel constructed by them has a higher diagnostic value (AUC = 0.902). Through the analysis of the TCGA data set, the target gene of the three‐miRNA panel may be KLF7, NRG1, SH3BGRL2, and SYNPO2.
Conclusion
The three‐miRNA panel (miR‐29c‐3p, miR‐143‐5p, and miR‐205‐5p) may become a novel non‐invasive biological marker for nasopharyngeal cancer screening.
Our study showed that a panel of three serum microRNAs may be performed as a novel and non‐invasive biomarker to diagnose nasopharyngeal carcinoma, with AUC = 0.902. And the development of nasopharyngeal carcinoma may relate to the three‐miRNA panel, the further study was needed to do.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.24194</identifier><identifier>PMID: 35028969</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; Biomarkers ; Biomarkers, Tumor - blood ; Cancer ; Cancer screening ; Circulating MicroRNA - blood ; Early Detection of Cancer - methods ; Epidemiology ; Female ; Gene expression ; Gene Expression Profiling ; Humans ; Male ; Medical prognosis ; microRNA ; MicroRNAs ; Middle Aged ; miRNA ; Nasopharyngeal carcinoma ; Nasopharyngeal Carcinoma - blood ; Nasopharyngeal Carcinoma - diagnosis ; Nasopharyngeal Carcinoma - genetics ; ROC Curve ; Sensitivity and Specificity ; Throat cancer ; Tumors</subject><ispartof>Journal of clinical laboratory analysis, 2022-02, Vol.36 (2), p.e24194-n/a</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC.</rights><rights>2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4484-bb809212e535cc8a4cec7becafa486a47bca9092bb88fdaffc6706e26852294a3</citedby><cites>FETCH-LOGICAL-c4484-bb809212e535cc8a4cec7becafa486a47bca9092bb88fdaffc6706e26852294a3</cites><orcidid>0000-0002-5353-9355</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842135/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842135/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35028969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Rongkang</creatorcontrib><creatorcontrib>Lu, Chong</creatorcontrib><creatorcontrib>Yang, Weiqiang</creatorcontrib><creatorcontrib>Zhou, Yaqi</creatorcontrib><creatorcontrib>Zhong, Jiatao</creatorcontrib><creatorcontrib>Chen, Xuan</creatorcontrib><creatorcontrib>Li, Xinji</creatorcontrib><creatorcontrib>Huang, Guocheng</creatorcontrib><creatorcontrib>Peng, Xiqi</creatorcontrib><creatorcontrib>Liu, Kaihao</creatorcontrib><creatorcontrib>Zhang, Chunduo</creatorcontrib><creatorcontrib>Hu, Hongyi</creatorcontrib><creatorcontrib>Lai, Yongqing</creatorcontrib><title>A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non‐invasive biomarker for cancer detection.
Methods
The experiment is divided into three stages, namely, the screening stage, the training stage, and the verification stage. We took 54 patients with nasopharyngeal carcinoma and 108 healthy controls as the research objects. We use the receiver‐operating characteristic (ROC) curve and area under the ROC curve (AUC) to evaluate the diagnostic value of miRNA. Finally, a three‐miRNA panel with high diagnostic efficiency was constructed. In addition, we conducted biological information analysis of these miRNAs to explore their functions.
Results
In NPC patients, the expression of five serum miRNAs (miR‐29c‐3p, miR‐143‐5p, miR‐150‐5p, miR‐145‐3p, and miR‐205‐5p) is significantly dysregulated. Among them, the diagnostic value of these three miRNAs (miR‐29c‐3p, AUC = 0.702; miR‐143‐5p, AUC = 0.733; and miR‐205‐5p, AUC = 787) is more prominent. The diagnostic panel constructed by them has a higher diagnostic value (AUC = 0.902). Through the analysis of the TCGA data set, the target gene of the three‐miRNA panel may be KLF7, NRG1, SH3BGRL2, and SYNPO2.
Conclusion
The three‐miRNA panel (miR‐29c‐3p, miR‐143‐5p, and miR‐205‐5p) may become a novel non‐invasive biological marker for nasopharyngeal cancer screening.
Our study showed that a panel of three serum microRNAs may be performed as a novel and non‐invasive biomarker to diagnose nasopharyngeal carcinoma, with AUC = 0.902. And the development of nasopharyngeal carcinoma may relate to the three‐miRNA panel, the further study was needed to do.</description><subject>Adult</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Circulating MicroRNA - blood</subject><subject>Early Detection of Cancer - methods</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>microRNA</subject><subject>MicroRNAs</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Carcinoma - blood</subject><subject>Nasopharyngeal Carcinoma - diagnosis</subject><subject>Nasopharyngeal Carcinoma - genetics</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Throat cancer</subject><subject>Tumors</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90UFr2zAYBmBRNtq022U_YAh2KQW3kizb8mUQwtpthBZGexaflc-JUlvyJHsj_37K0pWth5180MPL6-8l5B1nl5wxcbU1HVwKyWt5RGac1SoTShSvyIwpVWWK8fyEnMa4ZYypmpfH5CQvmFB1Wc_I45wO4LCjvqXjJiDSiGHqaW9N8N9u59SAow3SKeKKQqSDH9GNFjq6srB2Po7W0Mb6HsIjhkhbH6iD6IcNhJ1bY4IGgrEuiTfkdQtdxLdP3zPycP3pfvE5W97dfFnMl5mRUsmsaRSrBRdY5IUxCqRBUzVooAWpSpBVY6BOIjnVrqBtTVmxEkWpCiFqCfkZ-XjIHaamx5VJhQN0egg2tdxpD1b_--LsRq_9D62UFDwvUsD5U0Dw3yeMo-5tNNh16VJ-ilqUgrEq3ZIl-uEF3fopuPR7e6VEIqxK6uKg0lFjDNg-l-FM7zfU-w317w0Tfv93_Wf6Z7QE-AH8tB3u_hOlvy6W80PoL4q3qQk</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Li, Rongkang</creator><creator>Lu, Chong</creator><creator>Yang, Weiqiang</creator><creator>Zhou, Yaqi</creator><creator>Zhong, Jiatao</creator><creator>Chen, Xuan</creator><creator>Li, Xinji</creator><creator>Huang, Guocheng</creator><creator>Peng, Xiqi</creator><creator>Liu, Kaihao</creator><creator>Zhang, Chunduo</creator><creator>Hu, Hongyi</creator><creator>Lai, Yongqing</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5353-9355</orcidid></search><sort><creationdate>202202</creationdate><title>A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma</title><author>Li, Rongkang ; Lu, Chong ; Yang, Weiqiang ; Zhou, Yaqi ; Zhong, Jiatao ; Chen, Xuan ; Li, Xinji ; Huang, Guocheng ; Peng, Xiqi ; Liu, Kaihao ; Zhang, Chunduo ; Hu, Hongyi ; Lai, Yongqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4484-bb809212e535cc8a4cec7becafa486a47bca9092bb88fdaffc6706e26852294a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Cancer</topic><topic>Cancer screening</topic><topic>Circulating MicroRNA - blood</topic><topic>Early Detection of Cancer - methods</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>microRNA</topic><topic>MicroRNAs</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Carcinoma - blood</topic><topic>Nasopharyngeal Carcinoma - diagnosis</topic><topic>Nasopharyngeal Carcinoma - genetics</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Throat cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rongkang</creatorcontrib><creatorcontrib>Lu, Chong</creatorcontrib><creatorcontrib>Yang, Weiqiang</creatorcontrib><creatorcontrib>Zhou, Yaqi</creatorcontrib><creatorcontrib>Zhong, Jiatao</creatorcontrib><creatorcontrib>Chen, Xuan</creatorcontrib><creatorcontrib>Li, Xinji</creatorcontrib><creatorcontrib>Huang, Guocheng</creatorcontrib><creatorcontrib>Peng, Xiqi</creatorcontrib><creatorcontrib>Liu, Kaihao</creatorcontrib><creatorcontrib>Zhang, Chunduo</creatorcontrib><creatorcontrib>Hu, Hongyi</creatorcontrib><creatorcontrib>Lai, Yongqing</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Rongkang</au><au>Lu, Chong</au><au>Yang, Weiqiang</au><au>Zhou, Yaqi</au><au>Zhong, Jiatao</au><au>Chen, Xuan</au><au>Li, Xinji</au><au>Huang, Guocheng</au><au>Peng, Xiqi</au><au>Liu, Kaihao</au><au>Zhang, Chunduo</au><au>Hu, Hongyi</au><au>Lai, Yongqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2022-02</date><risdate>2022</risdate><volume>36</volume><issue>2</issue><spage>e24194</spage><epage>n/a</epage><pages>e24194-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non‐invasive biomarker for cancer detection.
Methods
The experiment is divided into three stages, namely, the screening stage, the training stage, and the verification stage. We took 54 patients with nasopharyngeal carcinoma and 108 healthy controls as the research objects. We use the receiver‐operating characteristic (ROC) curve and area under the ROC curve (AUC) to evaluate the diagnostic value of miRNA. Finally, a three‐miRNA panel with high diagnostic efficiency was constructed. In addition, we conducted biological information analysis of these miRNAs to explore their functions.
Results
In NPC patients, the expression of five serum miRNAs (miR‐29c‐3p, miR‐143‐5p, miR‐150‐5p, miR‐145‐3p, and miR‐205‐5p) is significantly dysregulated. Among them, the diagnostic value of these three miRNAs (miR‐29c‐3p, AUC = 0.702; miR‐143‐5p, AUC = 0.733; and miR‐205‐5p, AUC = 787) is more prominent. The diagnostic panel constructed by them has a higher diagnostic value (AUC = 0.902). Through the analysis of the TCGA data set, the target gene of the three‐miRNA panel may be KLF7, NRG1, SH3BGRL2, and SYNPO2.
Conclusion
The three‐miRNA panel (miR‐29c‐3p, miR‐143‐5p, and miR‐205‐5p) may become a novel non‐invasive biological marker for nasopharyngeal cancer screening.
Our study showed that a panel of three serum microRNAs may be performed as a novel and non‐invasive biomarker to diagnose nasopharyngeal carcinoma, with AUC = 0.902. And the development of nasopharyngeal carcinoma may relate to the three‐miRNA panel, the further study was needed to do.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>35028969</pmid><doi>10.1002/jcla.24194</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5353-9355</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Biomarkers Biomarkers, Tumor - blood Cancer Cancer screening Circulating MicroRNA - blood Early Detection of Cancer - methods Epidemiology Female Gene expression Gene Expression Profiling Humans Male Medical prognosis microRNA MicroRNAs Middle Aged miRNA Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - blood Nasopharyngeal Carcinoma - diagnosis Nasopharyngeal Carcinoma - genetics ROC Curve Sensitivity and Specificity Throat cancer Tumors |
| title | A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma |
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