Guayule Natural Rubber Latex and Bi2O3 Films for X-ray Attenuating Medical Gloves

Existing natural latex radiation-attenuating gloves (RAGs) contain a high loading of radiation attenuation filler that reduces their mechanical properties to below Food and Drug Administration (FDA) medical glove requirements. RAGs are commonly formulated using Hevea natural rubber latex and lead-ba...

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Veröffentlicht in:Materials 2022-02, Vol.15 (3), p.1184
Hauptverfasser: Ramirez Cadavid, David A., Layman, Rick R., Nishino, Thomas, Slutzky, J. Lauren, Li, Zhenyu, Cornish, Katrina
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container_issue 3
container_start_page 1184
container_title Materials
container_volume 15
creator Ramirez Cadavid, David A.
Layman, Rick R.
Nishino, Thomas
Slutzky, J. Lauren
Li, Zhenyu
Cornish, Katrina
description Existing natural latex radiation-attenuating gloves (RAGs) contain a high loading of radiation attenuation filler that reduces their mechanical properties to below Food and Drug Administration (FDA) medical glove requirements. RAGs are commonly formulated using Hevea natural rubber latex and lead-based fillers. The former can cause life-threatening allergic responses and the latter are known for their toxicity. In this work, a new lead-free RAG formulation based on circumallergenic guayule natural rubber latex (GNRL) and non-toxic radiation attenuation filler bismuth trioxide (Bi2O3) was developed. GNRL films with Bi2O3 loadings ranging from 0 to 300 PHR at different thicknesses were prepared. Radiation attenuation efficiencies (AE) at 60, 80, 100, and 120 kVp were determined and attenuation isocontour curves predicted film thickness and Bi2O3 loading required to meet or exceed the radiation attenuation requirements of ASTM D7866 and commercial RAGs. Optimal curing conditions for GNRL/Bi2O3 films with 150 PHR Bi2O3 were investigated by varying curing temperatures and time from 87 °C to 96 °C and 65 min to 90 min, respectively. In general, as the loading of the filler increased, the density of the films increased while the thickness decreased. GNRL/Bi2O3 films with 150 PHR Bi2O3 and 0.27 mm provided 5% more AE than RAG market average attenuation at the same thickness. The films with 150 PHR Bi2O3 cured under near-optimal conditions (90 °C/85 min, and 87 °C/65 min) met both the radiation attenuation standard (ASTM D7866) and the natural latex surgeon and examination glove standards (ASTM D3577 and D3578, respectively). Thus, gloves made using our formulations and protocols demonstrated potential to meet and surpass medical natural latex glove standards, offer a single product for both infection control and radiation protection instead of double-gloving, provide a greater degree of comfort to the user, and simultaneously reduce contact reactions and eliminate potential latex allergic reaction.
doi_str_mv 10.3390/ma15031184
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source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Allergic reactions
Attenuation
Bismuth oxides
Bismuth trioxide
Contact potentials
Elastomers
Fillers
Film thickness
Gloves
Guayule
Hands
Laboratories
Latex
Lead free
Mechanical properties
Natural rubber
Radiation
Radiation protection
Rubber
Toxicity
title Guayule Natural Rubber Latex and Bi2O3 Films for X-ray Attenuating Medical Gloves
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