Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices

Ascorbic acid (AA; a.k.a. vitamin C) is well known for its cellular protection in environments of high oxidative stress. Even though physiological concentrations of AA in the brain are significant (0.2-10 mM), surprisingly little is known concerning the role of AA in synaptic neurotransmission under...

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Veröffentlicht in:	Nutrients 2022-01, Vol.14 (3), p.613
Hauptverfasser:	Heruye, Segewkal H, Warren, Ted J, Kostansek Iv, Joseph A, Draves, Samantha B, Matthews, Stephanie A, West, Peter J, Simeone, Kristina A, Simeone, Timothy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic acid Ascorbic Acid - pharmacology Brain Brain slice preparation Free radicals Hippocampal plasticity Hippocampus Long-term potentiation Long-Term Potentiation - physiology Mice Neuronal Plasticity - physiology Neurotransmission Neurotransmitter release Neurotransmitters Oscillations Oxidative stress Physiology Plasticity Regression analysis Signal processing Software Synapses Synaptic plasticity Synaptic Transmission - physiology Vitamin C
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