Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion

Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC) 1 . The extracellular matrix (ECM) contributes to immune exclusion 2 . However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes 3 , 4 . H...

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Veröffentlicht in:	Nature (London) 2021-11, Vol.599 (7886), p.673-678
Hauptverfasser:	Sun, Xiujie, Wu, Bogang, Chiang, Huai-Chin, Deng, Hui, Zhang, Xiaowen, Xiong, Wei, Liu, Junquan, Rozeboom, Aaron M., Harris, Brent T., Blommaert, Eline, Gomez, Antonio, Garcia, Roderic Espin, Zhou, Yufan, Mitra, Payal, Prevost, Madeleine, Zhang, Deyi, Banik, Debarati, Isaacs, Claudine, Berry, Deborah, Lai, Catherine, Chaldekas, Krysta, Latham, Patricia S., Brantner, Christine A., Popratiloff, Anastas, Jin, Victor X., Zhang, Ningyan, Hu, Yanfen, Pujana, Miguel Angel, Curiel, Tyler J., An, Zhiqiang, Li, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/31 13/44 13/51 14 14/19 14/63 38 38/39 38/70 38/77 38/90 42 42/41 45 59 631/67/1347 631/67/327 64 64/60 82 82/29 82/51 82/80 82/83 96 96/21 96/31 96/95 Ablation Alignment Animal models Animals Antibodies Breast cancer Cell Line, Tumor Collagen Collagen - metabolism Discoidin Domain Receptor 1 - antagonists & inhibitors Discoidin Domain Receptor 1 - deficiency Discoidin Domain Receptor 1 - genetics Discoidin Domain Receptor 1 - metabolism Disease Models, Animal Domains Extracellular matrix Extracellular Matrix - immunology Extracellular Matrix - metabolism Female Fibers Gene Deletion Gene expression Gene Knockout Techniques Genetic aspects Health aspects Humanities and Social Sciences Humans Immune response Immunocompetence Immunocompetence - immunology Immunotherapy Kinases Lymphocytes Lymphocytes T Metastases Mice multidisciplinary Physiological aspects Protein-tyrosine kinase Receptors Reconfiguration Science Science (multidisciplinary) Signal transduction T-Lymphocytes - cytology T-Lymphocytes - immunology Triple Negative Breast Neoplasms - immunology Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - therapy Tumor Escape Tumors Tyrosine
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