The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial
Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in KTx recipients. We conducted a retrospective study involving 7...
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| Veröffentlicht in: | Journal of clinical medicine 2022-01, Vol.11 (3), p.654 |
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| creator | Jehn, Ulrich Kortenhorn, Anja Schütte-Nütgen, Katharina Thölking, Gerold Westphal, Florian Strauss, Markus Wennmann, Dirk-Oliver Pavenstädt, Hermann Suwelack, Barbara Görlich, Dennis Reuter, Stefan |
| description | Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in KTx recipients. We conducted a retrospective study involving 711 adult patients (4608 patient-years) who were transplanted at our center between January 2007 and June 2015. Clinical data were extracted from patients' electronic medical records. Different laboratory and clinical parameters for mineral bone disease (MBD) and osteoporosis, including medication, were evaluated. We chose fracture events unrelated to malignancies or adequate trauma as the primary endpoint. Osteoporotic fractures occurred in 47 (6.6%) patients (median 36.7 months, IQR 45.9) after KTx (fracture incidence of 10 per 1000 person-years). Prior to KTx, subtotal PTX was performed in 116 patients (16.3%, median time 4.2 years before KTx, IQR 5.0). Of the patients with fracture (
= 47), only one (2.2%) patient had previously undergone PTX. After adjusting for the known fracture risk factors MBD and osteoporosis, PTX remained a protective factor against fractures (HR 0.134, CI 0.018-0.991,
= 0.049). We observed a reduced risk for pathological fractures in KTx patients who underwent PTX, independent from elevated parathyroid hormone at the time of KTx or afterwards. |
| doi_str_mv | 10.3390/jcm11030654 |
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= 47), only one (2.2%) patient had previously undergone PTX. After adjusting for the known fracture risk factors MBD and osteoporosis, PTX remained a protective factor against fractures (HR 0.134, CI 0.018-0.991,
= 0.049). We observed a reduced risk for pathological fractures in KTx patients who underwent PTX, independent from elevated parathyroid hormone at the time of KTx or afterwards.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11030654</identifier><identifier>PMID: 35160109</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Clinical medicine ; Fractures ; Kidney transplants ; Laboratories ; Metabolism ; Mortality ; Osteoporosis ; Patients ; Regression analysis ; Trauma ; Vitamin D</subject><ispartof>Journal of clinical medicine, 2022-01, Vol.11 (3), p.654</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-6478d44abe9a29e75d2a224d9dcd244385fa84343e359df016e6c0b3128c56193</citedby><cites>FETCH-LOGICAL-c409t-6478d44abe9a29e75d2a224d9dcd244385fa84343e359df016e6c0b3128c56193</cites><orcidid>0000-0003-3180-6245 ; 0000-0002-2574-9419 ; 0000-0001-6345-6206 ; 0000-0003-1136-438X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35160109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jehn, Ulrich</creatorcontrib><creatorcontrib>Kortenhorn, Anja</creatorcontrib><creatorcontrib>Schütte-Nütgen, Katharina</creatorcontrib><creatorcontrib>Thölking, Gerold</creatorcontrib><creatorcontrib>Westphal, Florian</creatorcontrib><creatorcontrib>Strauss, Markus</creatorcontrib><creatorcontrib>Wennmann, Dirk-Oliver</creatorcontrib><creatorcontrib>Pavenstädt, Hermann</creatorcontrib><creatorcontrib>Suwelack, Barbara</creatorcontrib><creatorcontrib>Görlich, Dennis</creatorcontrib><creatorcontrib>Reuter, Stefan</creatorcontrib><title>The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in KTx recipients. We conducted a retrospective study involving 711 adult patients (4608 patient-years) who were transplanted at our center between January 2007 and June 2015. Clinical data were extracted from patients' electronic medical records. Different laboratory and clinical parameters for mineral bone disease (MBD) and osteoporosis, including medication, were evaluated. We chose fracture events unrelated to malignancies or adequate trauma as the primary endpoint. Osteoporotic fractures occurred in 47 (6.6%) patients (median 36.7 months, IQR 45.9) after KTx (fracture incidence of 10 per 1000 person-years). Prior to KTx, subtotal PTX was performed in 116 patients (16.3%, median time 4.2 years before KTx, IQR 5.0). Of the patients with fracture (
= 47), only one (2.2%) patient had previously undergone PTX. After adjusting for the known fracture risk factors MBD and osteoporosis, PTX remained a protective factor against fractures (HR 0.134, CI 0.018-0.991,
= 0.049). We observed a reduced risk for pathological fractures in KTx patients who underwent PTX, independent from elevated parathyroid hormone at the time of KTx or afterwards.</description><subject>Clinical medicine</subject><subject>Fractures</subject><subject>Kidney transplants</subject><subject>Laboratories</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Osteoporosis</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Trauma</subject><subject>Vitamin D</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkV1rFDEUhoMottReeS8BbwQZzddkMl4IZbFaLFR0vQ7Z5Ew3y0wyJpnC_gl_s1lay2puckIeHt5zDkIvKXnHeU_e7-xEKeFEtuIJOmWk6xrCFX96VJ-g85x3pB6lBKPdc3TCWyoJJf0p-r3eAr4Kw7hAsIDjgL-ZZMp2n6J3YEuc9jgGfJMLxDmmWLzFl8nYsiTI2Af81bsAe7xOJuR5NKHg72D97CGU_KHWeRlLxkOKEzb1WVLMc_X6O8A_fLgdoVlVFFI1eDO-QM8GM2Y4f7jP0M_LT-vVl-b65vPV6uK6sYL0pZGiU04Is4HesB661jHDmHC9s44JwVU7GCW44MDb3g2ESpCWbDhlyraS9vwMfbz3zstmAmdrhGRGPSc_mbTX0Xj970_wW30b77RSXMruIHjzIEjx1wK56MlnC2OdAMQlayZZTySTrazo6__QXVxSqO0dqK7qZNdV6u09ZeuEcoLhMQwl-rBqfbTqSr86zv_I_l0s_wOU-qbH</recordid><startdate>20220127</startdate><enddate>20220127</enddate><creator>Jehn, Ulrich</creator><creator>Kortenhorn, Anja</creator><creator>Schütte-Nütgen, Katharina</creator><creator>Thölking, Gerold</creator><creator>Westphal, Florian</creator><creator>Strauss, Markus</creator><creator>Wennmann, Dirk-Oliver</creator><creator>Pavenstädt, Hermann</creator><creator>Suwelack, Barbara</creator><creator>Görlich, Dennis</creator><creator>Reuter, Stefan</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3180-6245</orcidid><orcidid>https://orcid.org/0000-0002-2574-9419</orcidid><orcidid>https://orcid.org/0000-0001-6345-6206</orcidid><orcidid>https://orcid.org/0000-0003-1136-438X</orcidid></search><sort><creationdate>20220127</creationdate><title>The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial</title><author>Jehn, Ulrich ; Kortenhorn, Anja ; Schütte-Nütgen, Katharina ; Thölking, Gerold ; Westphal, Florian ; Strauss, Markus ; Wennmann, Dirk-Oliver ; Pavenstädt, Hermann ; Suwelack, Barbara ; Görlich, Dennis ; Reuter, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-6478d44abe9a29e75d2a224d9dcd244385fa84343e359df016e6c0b3128c56193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Clinical medicine</topic><topic>Fractures</topic><topic>Kidney transplants</topic><topic>Laboratories</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Osteoporosis</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Trauma</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jehn, Ulrich</creatorcontrib><creatorcontrib>Kortenhorn, Anja</creatorcontrib><creatorcontrib>Schütte-Nütgen, Katharina</creatorcontrib><creatorcontrib>Thölking, Gerold</creatorcontrib><creatorcontrib>Westphal, Florian</creatorcontrib><creatorcontrib>Strauss, Markus</creatorcontrib><creatorcontrib>Wennmann, Dirk-Oliver</creatorcontrib><creatorcontrib>Pavenstädt, Hermann</creatorcontrib><creatorcontrib>Suwelack, Barbara</creatorcontrib><creatorcontrib>Görlich, Dennis</creatorcontrib><creatorcontrib>Reuter, Stefan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jehn, Ulrich</au><au>Kortenhorn, Anja</au><au>Schütte-Nütgen, Katharina</au><au>Thölking, Gerold</au><au>Westphal, Florian</au><au>Strauss, Markus</au><au>Wennmann, Dirk-Oliver</au><au>Pavenstädt, Hermann</au><au>Suwelack, Barbara</au><au>Görlich, Dennis</au><au>Reuter, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2022-01-27</date><risdate>2022</risdate><volume>11</volume><issue>3</issue><spage>654</spage><pages>654-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in KTx recipients. We conducted a retrospective study involving 711 adult patients (4608 patient-years) who were transplanted at our center between January 2007 and June 2015. Clinical data were extracted from patients' electronic medical records. Different laboratory and clinical parameters for mineral bone disease (MBD) and osteoporosis, including medication, were evaluated. We chose fracture events unrelated to malignancies or adequate trauma as the primary endpoint. Osteoporotic fractures occurred in 47 (6.6%) patients (median 36.7 months, IQR 45.9) after KTx (fracture incidence of 10 per 1000 person-years). Prior to KTx, subtotal PTX was performed in 116 patients (16.3%, median time 4.2 years before KTx, IQR 5.0). Of the patients with fracture (
= 47), only one (2.2%) patient had previously undergone PTX. After adjusting for the known fracture risk factors MBD and osteoporosis, PTX remained a protective factor against fractures (HR 0.134, CI 0.018-0.991,
= 0.049). We observed a reduced risk for pathological fractures in KTx patients who underwent PTX, independent from elevated parathyroid hormone at the time of KTx or afterwards.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35160109</pmid><doi>10.3390/jcm11030654</doi><orcidid>https://orcid.org/0000-0003-3180-6245</orcidid><orcidid>https://orcid.org/0000-0002-2574-9419</orcidid><orcidid>https://orcid.org/0000-0001-6345-6206</orcidid><orcidid>https://orcid.org/0000-0003-1136-438X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Clinical medicine Fractures Kidney transplants Laboratories Metabolism Mortality Osteoporosis Patients Regression analysis Trauma Vitamin D |
| title | The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial |
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