The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies
Polyamines are essential biomolecules for normal cellular metabolism in humans. The roles of polyamines in cancer development have been widely discussed in recent years. Among all, spermine alongside with its acetylated derivative, N , N -Diacetylspermine, demonstrate a relationship with the diagnos...
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| Veröffentlicht in: | International journal of molecular sciences 2022-01, Vol.23 (3), p.1258 |
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| creator | Tse, Ryan Tsz-Hei Wong, Christine Yim-Ping Chiu, Peter Ka-Fung Ng, Chi-Fai |
| description | Polyamines are essential biomolecules for normal cellular metabolism in humans. The roles of polyamines in cancer development have been widely discussed in recent years. Among all, spermine alongside with its acetylated derivative, N
, N
-Diacetylspermine, demonstrate a relationship with the diagnosis and staging of various cancers, including lung, breast, liver, colorectal and urogenital. Numerous studies have reported the level of spermine in different body fluids and organ tissues in patients with different types of cancers. Currently, the role and the underlying mechanisms of spermine in cancer development and progression are still under investigation. This review summarized the roles of spermine in cancer development and as a diagnostic, prognostic and therapeutic tool in various cancers. |
| doi_str_mv | 10.3390/ijms23031258 |
| format | Article |
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, N
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Wong, Christine Yim-Ping ; Chiu, Peter Ka-Fung ; Ng, Chi-Fai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-f743a3aeb3156aa9fa7d2d5cfad055f9dbd9650453124bb5ba14e8a7754836ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetylation</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor</topic><topic>Biomolecules</topic><topic>Body fluids</topic><topic>Breast</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell growth</topic><topic>Colorectal cancer</topic><topic>Creatinine</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver diseases</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - therapy</topic><topic>Plasma</topic><topic>Polyamines</topic><topic>Polyamines - metabolism</topic><topic>Prognosis</topic><topic>Prostate</topic><topic>Review</topic><topic>Spermidine</topic><topic>Spermine</topic><topic>Spermine - analogs & derivatives</topic><topic>Spermine - chemistry</topic><topic>Spermine - metabolism</topic><topic>Spermine - physiology</topic><topic>Tumors</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tse, Ryan Tsz-Hei</creatorcontrib><creatorcontrib>Wong, Christine Yim-Ping</creatorcontrib><creatorcontrib>Chiu, Peter Ka-Fung</creatorcontrib><creatorcontrib>Ng, Chi-Fai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tse, Ryan Tsz-Hei</au><au>Wong, Christine Yim-Ping</au><au>Chiu, Peter Ka-Fung</au><au>Ng, Chi-Fai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-01-23</date><risdate>2022</risdate><volume>23</volume><issue>3</issue><spage>1258</spage><pages>1258-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Polyamines are essential biomolecules for normal cellular metabolism in humans. 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| subjects | Acetylation Biomarkers Biomarkers, Tumor Biomolecules Body fluids Breast Breast cancer Cancer Cancer therapies Cell growth Colorectal cancer Creatinine Humans Liver cancer Liver diseases Lung cancer Medical prognosis Neoplasms - genetics Neoplasms - metabolism Neoplasms - therapy Plasma Polyamines Polyamines - metabolism Prognosis Prostate Review Spermidine Spermine Spermine - analogs & derivatives Spermine - chemistry Spermine - metabolism Spermine - physiology Tumors Urine |
| title | The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies |
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