Deciphering Genetic Alterations of Taiwanese Patients with Pancreatic Adenocarcinoma through Targeted Sequencing

Pancreatic adenocarcinoma (PAC) is the 8th leading cause of cancer-related deaths in Taiwan, and its incidence is increasing. The development of PAC involves successive accumulation of multiple genetic alterations. Understanding the molecular pathogenesis and heterogeneity of PAC may facilitate pers...

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Veröffentlicht in:	International journal of molecular sciences 2022-01, Vol.23 (3), p.1579
Hauptverfasser:	Huang, Chi-Cheng, Liu, Chih-Yi, Huang, Chi-Jung, Hsu, Yao-Chun, Lien, Heng-Hui, Wong, Jia-Uei, Tai, Feng-Chuan, Ku, Wen-Hui, Hung, Chi-Feng, Lin, Jaw-Town, Huang, Ching-Shui, Chiang, Han-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Asian People - genetics Biomarkers Cancer therapies Chemical compounds Decision making Fibroblast growth factor receptor 2 Fibroblast growth factor receptors Genes Heterogeneity High-Throughput Nucleotide Sequencing Humans Metastases Metastasis Mutation Neoplasm Metastasis Next-generation sequencing p53 Protein Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Paraffins Patients Pharmacology Prospective Studies Protein-tyrosine kinase Proto-Oncogene Proteins p21(ras) - genetics Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Platelet-Derived Growth Factor alpha - genetics Retrospective Studies Sequence Analysis, DNA - methods Taiwan Tumor Suppressor Protein p53 - genetics Tumors Tyrosine
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