Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

Non-viral gene delivery has become a popular approach in tissue engineering, as it permits the transient delivery of a therapeutic gene, in order to stimulate tissue repair. However, the efficacy of non-viral delivery vectors remains an issue. Our lab has created gene-activated scaffolds by incorpor...

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Veröffentlicht in:	International journal of molecular sciences 2022-01, Vol.23 (3), p.1460
Hauptverfasser:	Power, Rachael N, Cavanagh, Brenton L, Dixon, James E, Curtin, Caroline M, O'Brien, Fergal J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Angiogenesis Animals Biocompatible Materials - pharmacology Biomedical materials Bone healing Bone marrow Calcium phosphates Cell-Penetrating Peptides - pharmacology Chemokine CXCL12 - administration & dosage Chemokine CXCL12 - pharmacology Chemokines Collagen Collagen - chemistry Defects DNA - chemistry Drug Delivery Systems Durapatite - chemistry Endothelial Progenitor Cells - metabolism Extracellular matrix Fractures Gene transfer Glycosaminoglycans Glycosaminoglycans - chemistry Growth factors Histidine Hydroxyapatite Injuries MicroRNAs Nanoparticles Neovascularization, Physiologic - drug effects Peptides Plasmids Plasmids - chemistry Precursors Proteins Rats Rats, Sprague-Dawley Repair Scaffolds Stem cells Tissue Engineering Tissue Scaffolds - chemistry Transcriptional Activation - drug effects Transfection
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