TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment

TRIM37 dysregulation has been observed in several cancer types, implicating its possible role in tumorigenesis. However, the role of TRIM37 in pancreatic cancer progression remains unclear. In the present study, we observed that TRIM37 knockdown resulted in reduced proliferation, clonogenicity, migr...

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Veröffentlicht in:	International journal of molecular sciences 2022-01, Vol.23 (3), p.1176
Hauptverfasser:	Do, Tuyen Thi, Yeh, Chun-Chieh, Wu, Guo-Wei, Hsu, Chia-Chen, Chang, Hung-Chih, Chen, Hui-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Cancer therapies CD11b antigen Cell adhesion & migration Cell growth Cell Movement Cell Proliferation Chemokines Cloning Cytokines Female Gene Expression Regulation, Neoplastic Humans In vivo methods and tests Localization Lung cancer Macrophages Mice Mice, Inbred C57BL Microenvironments Mutation Neoplasm Invasiveness Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein expression Proteins Regulation Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Tumor Cells, Cultured Tumor Microenvironment Tumorigenesis Tumors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Wound healing Xenograft Model Antitumor Assays
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