Pulsed Microwave Liver Ablation: An Additional Tool to Treat Hepatocellular Carcinoma
This study aimed to analyze the outcomes of HCC patients treated with a novel technique-pulsed microwave ablation (MWA)-in terms of safety, local tumor progression (LTP), intrahepatic recurrence (IHR), and overall survival (OS). A total of 126 pulsed microwave procedures have been performed in our c...
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| Veröffentlicht in: | Cancers 2022-01, Vol.14 (3), p.748 |
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| creator | Zanus, Giacomo Tagliente, Giovanni Rossi, Serena Bonis, Alessandro Zambon, Mattia Scopelliti, Michele Brizzolari, Marco Grossi, Ugo Romano, Maurizio Finotti, Michele |
| description | This study aimed to analyze the outcomes of HCC patients treated with a novel technique-pulsed microwave ablation (MWA)-in terms of safety, local tumor progression (LTP), intrahepatic recurrence (IHR), and overall survival (OS). A total of 126 pulsed microwave procedures have been performed in our center. We included patients with mono- or multifocal HCC (BCLC 0 to D). The LTP at 12 months was 9.9%, with an IHR rate of 27.8% at one year. Survival was 92.0% at 12 months with 29.4% experiencing post-operative complications (28.6% Clavien-Dindo 1-2, 0.8% Clavien-Dindo 3-4). Stratifying patients by BCLC, we achieved BCLC 0, A, B, C, and D survival rates of 100%, 93.2%, 93.3%, 50%, and 100%, respectively, at one year, which was generally superior to or in line with the expected survival rates among patients who are started on standard treatment. The pulsed MWA technique is safe and effective. The technique can be proposed not only in patients with BCLC A staging but also in the highly selected cases of BCLC B, C, and D, confirming the importance of the concept of stage migration. This procedure, especially if performed with a minimally invasive technique (laparoscopic or percutaneous), is repeatable with a short postoperative hospital stay. |
| doi_str_mv | 10.3390/cancers14030748 |
| format | Article |
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A total of 126 pulsed microwave procedures have been performed in our center. We included patients with mono- or multifocal HCC (BCLC 0 to D). The LTP at 12 months was 9.9%, with an IHR rate of 27.8% at one year. Survival was 92.0% at 12 months with 29.4% experiencing post-operative complications (28.6% Clavien-Dindo 1-2, 0.8% Clavien-Dindo 3-4). Stratifying patients by BCLC, we achieved BCLC 0, A, B, C, and D survival rates of 100%, 93.2%, 93.3%, 50%, and 100%, respectively, at one year, which was generally superior to or in line with the expected survival rates among patients who are started on standard treatment. The pulsed MWA technique is safe and effective. The technique can be proposed not only in patients with BCLC A staging but also in the highly selected cases of BCLC B, C, and D, confirming the importance of the concept of stage migration. This procedure, especially if performed with a minimally invasive technique (laparoscopic or percutaneous), is repeatable with a short postoperative hospital stay.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14030748</identifier><identifier>PMID: 35159014</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Ablation ; Algorithms ; Ascites ; Complications ; Hepatocellular carcinoma ; Hospitals ; Hypertension ; Laparoscopy ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Liver transplantation ; Patients ; Postoperative ; Surgery ; Survival ; Tumors</subject><ispartof>Cancers, 2022-01, Vol.14 (3), p.748</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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A total of 126 pulsed microwave procedures have been performed in our center. We included patients with mono- or multifocal HCC (BCLC 0 to D). The LTP at 12 months was 9.9%, with an IHR rate of 27.8% at one year. Survival was 92.0% at 12 months with 29.4% experiencing post-operative complications (28.6% Clavien-Dindo 1-2, 0.8% Clavien-Dindo 3-4). Stratifying patients by BCLC, we achieved BCLC 0, A, B, C, and D survival rates of 100%, 93.2%, 93.3%, 50%, and 100%, respectively, at one year, which was generally superior to or in line with the expected survival rates among patients who are started on standard treatment. The pulsed MWA technique is safe and effective. The technique can be proposed not only in patients with BCLC A staging but also in the highly selected cases of BCLC B, C, and D, confirming the importance of the concept of stage migration. This procedure, especially if performed with a minimally invasive technique (laparoscopic or percutaneous), is repeatable with a short postoperative hospital stay.</description><subject>Ablation</subject><subject>Algorithms</subject><subject>Ascites</subject><subject>Complications</subject><subject>Hepatocellular carcinoma</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Laparoscopy</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver transplantation</subject><subject>Patients</subject><subject>Postoperative</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc9LHDEcxUOpqKyevUnASy9b83tmPAjL0tbCFj2s5_CdzDc1MjtZk5kt_e-brVasySEJ-eSR9x4hZ5x9lrJhlw4GhylzxSSrVP2BHAtWibkxjfr4Zn9ETnN-ZGVIyStTHZIjqbluGFfH5P5u6jN29EdwKf6CHdJV2GGii7aHMcThii4Guui6sD9AT9cx9nSMdJ0QRnqDWxijw76fekh0CcmFIW7ghBx4KLqnL-uM3H_9sl7ezFe3374vF6u5U4KP86rumHK-8sqJTldGoGACW62MkbwWunVd65nXzHPwmgPKRnqDyqEBVezJGbl-1t1O7QY7h8OYoLfbFDaQftsIwf5_M4QH-zPubF2XBMuckU8vAik-TZhHuwl57wcGjFO2woiGGaFUXdCLd-hjnFLJ5C9VaamUloW6fKZKnDkn9K-f4czuW7PvWisvzt96eOX_dST_ADeSlGs</recordid><startdate>20220131</startdate><enddate>20220131</enddate><creator>Zanus, Giacomo</creator><creator>Tagliente, Giovanni</creator><creator>Rossi, Serena</creator><creator>Bonis, Alessandro</creator><creator>Zambon, Mattia</creator><creator>Scopelliti, Michele</creator><creator>Brizzolari, Marco</creator><creator>Grossi, Ugo</creator><creator>Romano, Maurizio</creator><creator>Finotti, Michele</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7055-7117</orcidid><orcidid>https://orcid.org/0000-0002-3659-2429</orcidid><orcidid>https://orcid.org/0000-0001-9965-1281</orcidid><orcidid>https://orcid.org/0000-0001-5489-3009</orcidid><orcidid>https://orcid.org/0000-0003-3101-7588</orcidid><orcidid>https://orcid.org/0000-0001-5372-2873</orcidid></search><sort><creationdate>20220131</creationdate><title>Pulsed Microwave Liver Ablation: An Additional Tool to Treat Hepatocellular Carcinoma</title><author>Zanus, Giacomo ; 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A total of 126 pulsed microwave procedures have been performed in our center. We included patients with mono- or multifocal HCC (BCLC 0 to D). The LTP at 12 months was 9.9%, with an IHR rate of 27.8% at one year. Survival was 92.0% at 12 months with 29.4% experiencing post-operative complications (28.6% Clavien-Dindo 1-2, 0.8% Clavien-Dindo 3-4). Stratifying patients by BCLC, we achieved BCLC 0, A, B, C, and D survival rates of 100%, 93.2%, 93.3%, 50%, and 100%, respectively, at one year, which was generally superior to or in line with the expected survival rates among patients who are started on standard treatment. The pulsed MWA technique is safe and effective. The technique can be proposed not only in patients with BCLC A staging but also in the highly selected cases of BCLC B, C, and D, confirming the importance of the concept of stage migration. This procedure, especially if performed with a minimally invasive technique (laparoscopic or percutaneous), is repeatable with a short postoperative hospital stay.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35159014</pmid><doi>10.3390/cancers14030748</doi><orcidid>https://orcid.org/0000-0002-7055-7117</orcidid><orcidid>https://orcid.org/0000-0002-3659-2429</orcidid><orcidid>https://orcid.org/0000-0001-9965-1281</orcidid><orcidid>https://orcid.org/0000-0001-5489-3009</orcidid><orcidid>https://orcid.org/0000-0003-3101-7588</orcidid><orcidid>https://orcid.org/0000-0001-5372-2873</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ablation Algorithms Ascites Complications Hepatocellular carcinoma Hospitals Hypertension Laparoscopy Liver cancer Liver cirrhosis Liver diseases Liver transplantation Patients Postoperative Surgery Survival Tumors |
| title | Pulsed Microwave Liver Ablation: An Additional Tool to Treat Hepatocellular Carcinoma |
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