Therapeutic Strategies Targeting Urokinase and Its Receptor in Cancer

Several studies have ascertained that uPA and uPAR do participate in tumor progression and metastasis and are involved in cell adhesion, migration, invasion and survival, as well as angiogenesis. Increased levels of uPA and uPAR in tumor tissues, stroma and biological fluids correlate with adverse c...

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Veröffentlicht in:	Cancers 2022-01, Vol.14 (3), p.498
Hauptverfasser:	Masucci, Maria Teresa, Minopoli, Michele, Di Carluccio, Gioconda, Motti, Maria Letizia, Carriero, Maria Vincenza
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Angiogenesis Binding sites Cancer Cell adhesion Cell adhesion & migration Cell membranes Cell migration Clinical trials Enzymes Fibrin Kinases Ligands Metastases Metastasis Patients Peptides Plasmin Review Stem cells Stroma Structure-function relationships Tumors U-Plasminogen activator
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