Convergent clonal selection of donor- and recipient-derived CMV-specific T cells in hematopoietic stem cell transplant patients

Competition between antigen-specific T cells for peptide:MHC complexes shapes the ensuing T cell response. Mouse model studies provided compelling evidence that competition is a highly effective mechanism controlling the activation of naïve T cells. However, assessing the effect of T cell competitio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-02, Vol.119 (6), p.1-12
Hauptverfasser:	Erickson, Jami R., Stevens-Ayers, Terry, Mair, Florian, Edmison, Bradley, Boeckh, Michael, Bradley, Philip, Prlic, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens Biological Sciences CD8-Positive T-Lymphocytes - immunology Cell activation Clonal selection Competition Convergence Cytomegalovirus Cytomegalovirus - physiology Cytomegalovirus Infections - immunology Epitopes Female Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Immunodominance Immunological memory Lymphocytes Lymphocytes T Major histocompatibility complex Male Memory cells Memory T Cells - immunology Middle Aged Populations Stem cell transplantation Stem cells T cell receptors Tissue Donors Transcriptomics Virus Activation - immunology
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