Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins down-regulated by viral factors expres...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-02, Vol.119 (6), p.1-7
Hauptverfasser:	Nightingale, Katie, Potts, Martin, Hunter, Leah M., Fielding, Ceri A., Zerbe, Cassie M., Fletcher-Etherington, Alice, Nobre, Luis, Wang, Eddie C. Y., Strang, Blair L., Houghton, Jack W., Antrobus, Robin, Suarez, Nicolas M., Nichols, Jenna, Davison, Andrew J., Stanton, Richard J., Weekes, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Biological Sciences Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology HIV Human immunodeficiency virus Humans Immune Evasion Immunity Innate immunity Nuclear Proteins - genetics Nuclear Proteins - immunology Plaques Proteins Proteolysis Proteomics Recruitment RNA viruses Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligase Complexes - genetics Ubiquitin-Protein Ligase Complexes - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral infections
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